Article
Dermatology
Qicheng Lan, Kaitao Wang, Zhefeng Meng, Hang Lin, Taotao Zhou, Yi Lin, Zhikai Jiang, Jianpeng Chen, Xuao Liu, Yuting Lin, Dingsheng Lin
Summary: This study investigated the effects of RXD on the survival of random skin flaps. The results showed that RXD promoted flap survival, increased angiogenesis, and decreased inflammation and oxidative stress.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Maryam Melaibari, Huda M. Alkreathy, Ahmed Esmat, Nisreen A. Rajeh, Rasheed A. Shaik, Anwar A. Alghamdi, Aftab Ahmad
Summary: The study examined the anti-fibrotic efficacy of apigenin against CCl4-induced hepatic fibrosis in mice. The results showed that apigenin significantly improved hepatic biomarkers, altered oxidative markers, and decreased inflammatory cytokine levels. Furthermore, apigenin treatment inhibited angiogenic activity. Therefore, apigenin may have potential as a therapeutic agent for hepatic fibrosis.
Article
Immunology
Yiwen Mao, Huiyao Ge, Weiwei Chen, YiRui Wang, Hao Liu, Zhuo Li, Yuanming Bai, Daiyue Wang, Yafen Yu, Qi Zhen, Bao Li, Liangdan Sun
Summary: The VEGF signal transduction pathway has been identified as a potential target for the treatment of psoriasis. RasGRP1, a downstream target gene of VEGF, plays a role in the development, homeostasis, and differentiation of T cells, but its contribution to psoriasis is limited.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Siarhei A. Dabravolski, Victoria A. Khotina, Andrey V. Omelchenko, Vladislav A. Kalmykov, Alexander N. Orekhov
Summary: The VEGF family plays a crucial role in the development of atherosclerosis and related cardiovascular diseases, and has the potential to be targeted for treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Anna Di Carlo, Sara Beji, Silvia Palmerio, Mario Picozza, Marco D'Agostino, Vincenzo Petrozza, Roberta Melchionna, Antonia Germani, Alessandra Magenta, Elena De Falco, Daniele Avitabile
Summary: Nucleophosmin (NPM) is secreted by human vein endothelial cells in response to stress conditions, showing pro-inflammatory and angiogenic activities both in vitro and in vivo. The secretion of NPM is time dependent and unrelated to cell necrosis within 24 hours. This study suggests a potential autocrine/paracrine role of NPM in regulating angiogenesis and inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Juan Zhang, Yeye Ma, Yue Zhang, Sijia Niu, Maolin Chu, Zhiyi Zhang
Summary: Angiogenesis is a crucial process in the development of rheumatoid arthritis (RA), and arsenic trioxide (ATO) has been found to inhibit synovial angiogenesis through VEGF modulation in RA fibroblast-like synoviocytes (RA-FLS). CircHIPK3, a circRNA, is significantly upregulated in RA-FLS and plays a role in regulating VEGF expression via targeting miR-149-5p and FOXO1. ATO can downregulate the angiogenic functional module of circHIPK3/miR-149-5p/FOXO1/VEGF, providing a protective effect on RA-FLS and CIA synovium.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Yincang Wang, Xiaodong Li, Hang Lv, Lin Sun, Bo Liu, Xiaofeng Zhang, Xilin Xu
Summary: Naringin, the main component of Drynaria, has been found to possess a wide range of pharmacological activities, including antioxidant, anti-inflammatory, anti-apoptotic, anti-ulcer, and anti-osteoporosis effects. This review explores the pharmacological effects and associated mechanisms of naringin in improving flap survival, providing a reference for future research on the rational application of naringin to enhance flap survival.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Alexandra C. Costa, Joana M. O. Santos, Beatriz Medeiros-Fonseca, Paula A. Oliveira, Margarida M. S. M. Bastos, Haissa O. Brito, Rui M. Gil da Costa, Rui Medeiros
Summary: The study found that increased mast cell infiltration is associated with the progression of HPV-induced lesions. miR-223-3p and miR-125b-5p may regulate mast cell chemotactic proteins and contribute to this process.
Article
Medicine, Research & Experimental
Mariko Miyashita-Ishiwata, Malak El Sabeh, Lauren D. Reschke, Sadia Afrin, Mostafa A. Borahay
Summary: This study reveals an aberrant response of leiomyoma cells to hypoxia, characterized by increased cell proliferation and secretion of angiogenic factors. This abnormal response may contribute to the development and growth of leiomyoma.
Article
Biochemistry & Molecular Biology
Jinchao Li, Ying Tang, Ting-Chun Lin, Huawei Zeng, Joel B. Mason, Zhenhua Liu
Summary: Strong evidence suggests an association between body fatness and the development of colorectal cancer (CRC), but there is still limited understanding of the causality between obesity and CRC. This study investigates the role of TNF-alpha in obesity-associated CRC development. The research shows that the deletion of TNF-alpha reduces inflammation and Wnt signaling, thereby attenuating obesity-induced intestinal tumorigenesis. Targeting TNF-alpha signaling may be a potential strategy for reducing the risk of CRC associated with obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Neurosciences
Yang Li, Tingting Ma, Xiaoyu Zhu, Mingqi Zhang, Liang Zhao, Peng Wang, Jia Liang
Summary: This study found that zinc improves neurological function recovery during the cerebral ischemia repair stage by promoting astrocyte induced angiogenesis. Zinc alleviates brain atrophy and enhances neurological function recovery. Furthermore, zinc increases the protein levels of HIF-1 alpha, VEGF-A, and VEGF-R2 in astrocytes, thereby promoting angiogenesis during cerebral ischemic repair.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Biotechnology & Applied Microbiology
Ling Sun
Summary: Silencing FBXW7 upregulates the HIF-1α/VEGF signaling pathway, promoting angiogenesis in neonatal rats with hypoxic-ischemic brain damage (HIBD) after brain injury, reducing infarct volume and improving recovery of nerve function in HIBD rats.
Article
Biochemistry & Molecular Biology
Fen Sun, Hui Cai, Lunbo Tan, Dezhe Qin, Jian Zhang, Jinlian Hua, Xiujun Fan, Sha Peng
Summary: This study demonstrates that miR-125b can affect embryo implantation by modulating placenta angiogenesis and trophoblast cell invasion capacity, which may lead to pregnancy loss.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Materials Science, Multidisciplinary
Hongfei Ge, Quan Hu, Tunan Chen, Yang Yang, Chao Zhang, Jun Zhong, Yi Yin, Xuheng Jiang, Xin Zhou, Shuhong Wang, Rong Hu, Wenyan Li, Hua Feng
Summary: A feasible method for modifying grafted neural stem cells (NSCs) using layer-by-layer (LbL) assembly has been developed, which enhances their regenerative ability and survival rate, showing potential application in the treatment of ischemic stroke.
APPLIED MATERIALS TODAY
(2022)
Article
Oncology
Ali Abdalla, Chandraprabha Murali, Amr Amin
Summary: This study reveals for the first time the antiangiogenic potential of safranal and proposes its possible underlying mechanism in the treatment of hepatocellular carcinoma (HCC).
FRONTIERS IN ONCOLOGY
(2022)
Article
Clinical Neurology
Fengshui Chang, Qi Zhang, Haixia Xie, Yuhui Yang, Chen Shen, Xueyun Shen, Gang Chen, Airong Wu, Huifang Wang, Xiaohong Li, Jun Lu
Article
Automation & Control Systems
Zheng Wang, Jianping Yuan
JOURNAL OF THE FRANKLIN INSTITUTE-ENGINEERING AND APPLIED MATHEMATICS
(2020)
Article
Chemistry, Physical
Shuya Li, Zhi-Jun Li, Hyun Yu, Marion Ryan Sytu, Yunxuan Wang, Debora Beeri, Weiwei Zheng, Benjamin D. Sherman, Chang Geun Yoo, Gyu Leem
ACS ENERGY LETTERS
(2020)
Review
Oncology
Jian Li, Lin Shen
Article
Engineering, Environmental
Zhao Zheng, Yuxiang Li, Zuhua Zhang, Xue Ma
JOURNAL OF HAZARDOUS MATERIALS
(2020)
Article
Oncology
Liu Ziwei, Liu Tao, Zhang Xiaotong, Si Xiaoyan, Wang Hanping, Zhang Jingjia, Huang Hui, Sun Xuefeng, Wang Jinglan, Wang Mengzhao, Zhang Li
Article
Chemistry, Inorganic & Nuclear
Xiao-Yang Yu, Rui Zhang, Sheng-Ling Li, Shi-Hua Yu, Lu Gao, Wen-Fu Yan, Juan Jin, Ya-Nan Luo
INORGANIC CHEMISTRY COMMUNICATIONS
(2020)
Article
Cell Biology
Yaping Jiang, Chuanxi Yang, Yuxiang Zheng, Yining Liu, Yihui Chen
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Chemistry, Physical
Shuya Li, Saerona Kim, Andrew H. Davis, Jingshun Zhuang, Eric Wolfgang Shuler, Debora Willinger, Jae-Joon Lee, Weiwei Zheng, Benjamin D. Sherman, Chang Geun Yoo, Gyu Leem
Summary: Selective cleavage of C-C bonds in lignin at ambient temperature was achieved using a HAT-DSPEC system, which combines a dye-sensitized photoelectrochemical cell with a hydrogen atom transfer mediator under redox-neutral conditions. The system demonstrated excellent efficiency and selectivity in the cleavage of the C(aryl)-C(alkyl) bond under solar irradiation.
Article
Andrology
Chongfu Zhong, Chunlei Li, Qiang Geng, Qiang Han, Qinghe Gao, Jiwei Zhang, Fu Wang, Jun Guo
Summary: This study assessed the discontinuation rates and reasons for discontinuation of dapoxetine treatment in Chinese men with premature ejaculation. The study found a high discontinuation rate, with overexpectation of efficacy and high cost being the main reasons for discontinuation.
Article
Pharmacology & Pharmacy
Xiangping Wang, Changjie Huang, H. Chen
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2020)
Article
Biotechnology & Applied Microbiology
Yuexin Wang, Anna Jia, Yejin Cao, Xuelian Hu, Yufei Wang, Qiuli Yang, Yujing Bi, Guangwei Liu
CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION
(2020)
Article
Medicine, Research & Experimental
Xianding Sun, Ruobin Zhang, Hangang Chen, Xiaolan Du, Shuai Chen, Junlan Huang, Mi Liu, Meng Xu, Fengtao Luo, Min Jin, Nan Su, Huabing Qi, Jing Yang, Qiaoyan Tan, Dali Zhang, Zhenhong Ni, Sen Liang, Bin Zhang, Di Chen, Xin Zhang, Lingfei Luo, Lin Chen, Yangli Xie
Article
Chemistry, Physical
Linqiang Xu, Shiqi Liu, Han Zhang, Xiuying Zhang, Jingzhen Li, Jiahuan Yan, Bowen Shi, Jie Yang, Chen Yang, Lianqiang Xu, Xiaotian Sun, Jing Lu
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2020)
Meeting Abstract
Pharmacology & Pharmacy
Yufei Wang, Xiaofeng An, Mingyu Zhang
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2020)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
