Journal
ADVANCES IN MEDICAL SCIENCES
Volume 58, Issue 1, Pages 73-82Publisher
MEDICAL UNIV BIALYSTOK
DOI: 10.2478/v10039-012-0066-y
Keywords
breast cancer; non-small cell lung cancer; matrix metalloproteinase 9
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Purpose: Matrix metalloproteinases (MMPs) are implicated in cancer cells invasion and metastasis processes and have been investigated as potential cancer biomarkers. In this study MMP-9 gene expression and MMP-9-1562 C/T polymorphism in breast and non-small cell lung cancer patients' blood and tumor samples and its correlation with clinicopathological parameters were investigated. Material/Methods: MMP-9 gene expression was assessed by reverse transcription -polymerase chain reaction method in 108 cancer patients' blood and tumor samples. MMP-9-1562 C/T polymorphism was determined by the polymerase chain reaction -based restriction fragment length polymorphism method. Results: Significant relationship of MMP-9 gene expression and tumor differentiation grade was found only between groups with G1 and G3 breast tumors. Low survival rates were identified among positive MMP-9 expression in blood and ductal carcinoma of the breast (p=0.01) and negative progesterone receptor reaction (p=0.04). Significant differences in the distribution among genotypes were found between groups with stage I and stages III/IV (p=0.005) as well as between groups with lymph node status N0 and N1 (p< 0.001). Breast cancer patients with tumor differentiation grade G3 and identified CC variant had a longer survival time (p=0.014). Shorter survival time was found among positive MMP-9 expression in tumor and stage I non-small cell lung cancer patients with negative lymph node (p=0.012) and squamous cell carcinoma (p=0.019). Conclusions: Expression of MMP-9 in blood and tumor together indicates worse prognosis for breast cancer patients.
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