Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 7, Issue 46, Pages 25553-25559Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b07348
Keywords
DSPE-PEG-MTX; nanodrug; sustain/controlled drug release; self-targeted drug delivery; synergistic anticancer activity
Funding
- National Natural Science Foundation of China [31271071]
- Scientific and Technological Innovation Platform of Fujian Province of China [2014H2006]
- Fujian Province Medical Innovation Project [2014-CXB-350]
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We constructed 10-hydroxycamptothecin (CPT) nanodrugs with functionalization of lipid-PEG-methotrexate (MTX) to prepare high-drug-loaded,and sustained/controlled-release MTX-PEG-CPT nanorods (NRs), in which MTX drug itself can serve as a specific targeting ligand. The self-targeted nanodrug can codeliver both CPT and MTX drugs with distinct anticancer mechanisms. Furthermore, MTX-PEG-CPT NRs significantly reduced burst release, improved blood circulation and tumor accumulation, enhanced cellular uptake, and synergistically increased anticancer effect against tumor cells compared with MTX-PEG-CPT nanospheres (NSs) and either both free drugs or individual free drug. Therefore, the synergistic targeting/therapeuticy nano-multi-drug codelivery assisted by shape design may advantageously offer a promising new strategy for nano-medicine.
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