Article
Biochemistry & Molecular Biology
Kuo-Hua Lee, Yuan-Chia Chu, Ming-Tsun Tsai, Wei-Cheng Tseng, Yao-Ping Lin, Shuo-Ming Ou, Der-Cherng Tarng
Summary: This study used machine learning to predict the risk of end-stage renal disease (ESRD) in sepsis survivors. The researchers found that estimated glomerular filtration rates, hemoglobin, and proteinuria were important predictors of ESRD development.
Article
Biochemistry & Molecular Biology
Mahmoud M. Zakaria, Safaa A. Derbala, Ayman E. Salem, Amgad E. EL-Agroudy, Fatma M. El-Tantawy
Summary: The study found that ESRD patients have a significantly lower number of T-cell subsets compared to CKD patients, which is related to a higher degree of apoptosis in these cells.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Infectious Diseases
Jose Molto, Fredzzia Graterol, Adrian Curran, Natalia Ramos, Arkaitz Imaz, Diego Sandoval, Francisco Perez, Lucia Bailon, Saye Khoo, Laura Else, Roger Paredes
Summary: This study evaluated the effect of haemodialysis on doravirine concentrations in people living with HIV (PLWH) undergoing routine haemodialysis. The results showed that despite moderate removal of doravirine by haemodialysis, trough doravirine concentrations in plasma after the haemodialysis sessions remained in excess of the protein-binding-adjusted EC50 (5 ng/mL). Therefore, doravirine dosage adjustments are unnecessary in PLWH undergoing intermittent haemodialysis.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Ziad M. El-Zaatari, Luan D. Truong
Summary: Renal cell carcinoma (RCC) occurring in the setting of end-stage renal disease (ESRD) shows unique clinicopathological characteristics, with acquired cystic kidney disease-associated renal cell carcinoma (ACKD-RCC) and clear-cell papillary renal cell carcinoma (ccpRCC) being the most frequent types. Other types of RCC also occur in ESRD, albeit with different frequencies from the non-ESRD general population. While the histological features of RCC do not vary in the setting of ESRD vs. non-ESRD, other findings, such as multifocality and multiple tumor types, are more frequent in ESRD. Studies have generated novel and important knowledge of the etiology, epidemiology, diagnosis, treatment, immunophenotype, and molecular characteristics of ESRD-associated RCC.
Article
Endocrinology & Metabolism
Rodolfo J. Galindo, Francisco J. Pasquel, Priyathama Vellanki, Cesar Zambrano, Bonnie Albury, Citlalli Perez-Guzman, Zheng Ziduo, Guillermo E. Umpierrez
Summary: This study revealed significant metabolic differences among DKA patients with different levels of renal function, with beta-hydroxybutyrate levels potentially assisting in confirming the diagnosis of DKA in ESKD patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Cell Biology
Zaipul I. Md Dom, Eiichiro Satake, Jan Skupien, Bozena Krolewski, Kristina O'Neil, Jill A. Willency, Simon T. Dillon, Jonathan M. Wilson, Hiroki Kobayashi, Katsuhito Ihara, Towia A. Libermann, Marlon Pragnell, Kevin L. Duffin, Andrzej S. Krolewski
Summary: This study identified three elevated plasma proteins associated with protection against progressive renal decline and progression to endstage renal disease in individuals with diabetes. These protective proteins may serve as biomarkers for stratifying diabetic individuals by their risk of developing ESRD, and could be explored as potential therapeutics to delay or prevent ESRD onset.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Yinghui Wang, Lu Gao
Summary: Chronic kidney disease and cardiac insufficiency often co-exist, especially in uremic patients on hemodialysis. Impaired renal function is often indicative of poor prognosis in patients with cardiac insufficiency. Inflammation plays a significant role in the development of cardiovascular complications in patients with chronic kidney disease and is indicative of prognosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Lorry Aitkens, Jennifer L. Waller, Stephanie L. Baer, Azeem Mohammed, Sarah Tran, Budder Siddiqui, Sandeep Padala, Lufei Young, Mufaddal Kheda, Wendy B. Bollag
Summary: This study found that psoriasis is protective against pneumonia in patients with end-stage renal disease, with other factors such as the Charlson Comorbidity Index (CCI) and tobacco use being more strongly associated with increased risk for pneumonia.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2022)
Review
Medicine, General & Internal
Xu Jing, Wen Zhuyuan, Chen Aijun, Xiong Jianxia, Huang Kun, Wang Ping
Summary: Previous studies have shown that patients with psoriasis are at higher risk of developing CKD and ESRD compared with the general population, but data on the differences in occurrence between psoriasis and non-psoriatic controls are limited and inconsistent. This study conducted a meta-analysis of cohort studies to compare the probability of suffering CKD and ESRD in patients with or without psoriasis.
FRONTIERS IN MEDICINE
(2023)
Article
Clinical Neurology
Chang Min Heo, Won Ho Lee, Bong Soo Park, Yoo Jin Lee, Sihyung Park, Yang Wook Kim, Dong Ah Lee, Byeong Cheol Yoo, Kang Min Park
Summary: This study compares glymphatic dysfunction between patients with end-stage renal disease (ESRD) and healthy controls, and reveals the presence of glymphatic dysfunction in patients with ESRD as demonstrated by the DTI-ALPS index. Additionally, a significant positive correlation is found between the DTI-ALPS index and serum parathyroid hormone levels in ESRD patients.
FRONTIERS IN NEUROLOGY
(2022)
Article
Pharmacology & Pharmacy
Fung-Chang Sung, Ying-Chin Jong, Chih-Hsin Muo, Chih-Cheng Hsu, Wen-Chen Tsai, Yueh-Han Hsu
Summary: Through analyzing insurance claims data from Taiwan, we found that statin therapy may reduce mortality risks for hyperlipidemic patients, especially in those with end-stage renal disease. Hydrophilic statin therapy showed superior effects in reducing all-cause mortality and deaths from cancer.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Jong Joo Moon, Yong Woo Kim, Baek-Lok Oh, Kyungdo Han, Dong Ki Kim, Kwon Wook Joo, Yon Su Kim, Ki Ho Park, Hajeong Lee, Yong Chul Kim, Jin Wook Jeoung
Summary: This nationwide cohort study found that the incidence of primary open-angle glaucoma (POAG) was higher in patients with end stage renal disease (ESRD) and kidney transplantation recipients (KTRs) compared to healthy controls, but adjusting for confounding factors did not show a significant increase in risk. The incidence of primary angle-closure glaucoma (PACG) was higher in ESRD patients compared to healthy controls, while KTRs had a lower risk of PACG compared to ESRD patients.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Malgorzata Maraj, Paulina Hetwer, Beata Kusnierz-Cabala, Barbara Maziarz, Paulina Dumnicka, Marek Kuzniewski, Piotr Ceranowicz
Summary: In hemodialyzed patients, serum AGP is weakly associated with the dietary intake of several nutrients, emphasizing the importance of patients consuming adequate nutrients for their overall health.
Article
Gastroenterology & Hepatology
Sunil Taneja, Ajay Duseja, Manu Mehta, Arka De, Nipun Verma, Madhumita Premkumar, Radha K. Dhiman, Virendra Singh, Mini P. Singh, Radha K. Ratho, Raja Ramachandran, Vivek Kumar, Harbir S. Kohli
Summary: The study evaluated the safety and efficacy of Sofosbuvir plus Velpatasvir fixed-dose combination in treating CHC patients with ESRD on MHD. Results showed 100% of patients achieved ETR and 96% achieved SVR 12. All patients tolerated the combination without any serious adverse events.
LIVER INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Haruna Fukuzaki, Junichiro Nakata, Shuko Nojiri, Yuki Shimizu, Yuka Shirotani, Takuya Maeda, Toshiki Kano, Maiko Mishiro, Nao Nohara, Hiroaki Io, Yusuke Suzuki
Summary: The importance of shared decision-making (SDM) is widely recognized. This study aimed to clarify the effectiveness and long-term medical benefits of SDM in renal replacement therapy (RRT) for patients with end-stage renal disease (ESRD). The findings demonstrate the association between visiting an ESRD clinic, improved survival in ESRD patients, and the choice of different RRT modalities.
SCIENTIFIC REPORTS
(2023)