Article
Multidisciplinary Sciences
Takaya Ozeki, Michio Nagata, Takayuki Katsuno, Koji Inagaki, Kazunori Goto, Sawako Kato, Yoshinari Yasuda, Naotake Tsuboi, Shoichi Maruyama
Summary: This study analyzed the clinical implication of unclassified segmental lesions in Japanese adult patients with nephrotic syndrome compared to Columbia-classified FSGS. The results showed that unclassified segmental lesions may have equivalent clinical impact as Columbia classification of FSGS, with similar treatment responses and no significant difference in the decline of eGFR.
Article
Immunology
Ibrahim Batal, Pascale Khairallah, Astrid Weins, Nicole K. Andeen, Michael B. Stokes
Summary: Primary focal segmental glomerulosclerosis (FSGS) is a disease characterized by diffuse podocyte foot process effacement and nephrotic syndrome. It can recur after transplantation and is associated with immunogenetic factors. This study retrospectively investigated a cohort of kidney allograft recipients with primary FSGS and found a higher frequency of HLA-A30 antigen in patients with primary FSGS compared to healthy controls and deceased kidney donors. The study also revealed an association between donor HLA-A30 and recurrent FSGS in transplant patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Urology & Nephrology
Pilar Aunon, Natalia Polanco, Maria Jose Perez-Saez, Emilio Rodrigo, Asuncion Sancho, Julio Pascual, Amado Andres, Manuel Praga
Summary: The recurrence rate of FSGS after kidney transplantation is related to the presence of nephrotic syndrome at the time of diagnosis and the effectiveness of pre-emptive rituximab treatment.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Urology & Nephrology
Marijke Stryckers, Stefaan Van Oevelen, Priyanka Koshy, Ben Sprangers, Amaryllis H. Van Craenenbroeck
Summary: We present a case of nephrotic syndrome in a 38-year-old man shortly after initiation of guselkumab for plaque psoriasis treatment. Renal biopsy revealed focal segmental glomerulosclerosis (FSGS). The clinical course strongly suggests drug-induced FSGS, as the nephrotic syndrome resolved after discontinuation of the drug without relapse (2 years of follow-up). To the best of our knowledge, this is the first report of FSGS lesions associated with the use of an interleukin-23 inhibitor.
CLINICAL KIDNEY JOURNAL
(2023)
Review
Medicine, General & Internal
Hamza Naciri Bennani, Lionel Elimby, Florian Terrec, Paolo Malvezzi, Johan Noble, Thomas Jouve, Lionel Rostaing
Summary: This study assessed graft survival in FSGS kidney-transplant recipients and compared patients with and without relapse. The results showed a recurrence rate of 47% for FSGS, and pretransplant prophylaxis did not seem to reduce the risk of relapse.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Urology & Nephrology
Daniela Verzola, Michela Saio, Daniela Picciotto, Francesca Viazzi, Elisa Russo, Leda Cipriani, Annalisa Carta, Francesca Costigliolo, Gabriele Gaggero, Gennaro Salvidio, Pasquale Esposito, Giacomo Garibotto, Laura Poggi
Summary: The study found that an increased level of cell senescence, particularly the upregulation of p16(INK4A) in tubules, is an independent predictor for progression to end-stage renal disease in adult FSGS patients.
AMERICAN JOURNAL OF NEPHROLOGY
(2021)
Article
Immunology
Julie Oniszczuk, Anissa Moktefi, Aude Mausoleo, Nicolas Pallet, Stephanie Malard-Castagnet, Slim Fourati, Khalil El Karoui, Dil Sahali, Thomas Stehle, Anna Boueilh, Marie-Christine Verpont, Marie Matignon, David Buob, Philippe Grimbert, Vincent Audard
Summary: This case study reports a renal transplant recipient who developed renal complications, including nephrotic syndrome and acute kidney injury, after contracting non-severe COVID-19. The renal biopsy revealed focal and segmental glomerulosclerosis lesions. The donor had high-risk apolipoprotein L1 gene variants, which may have contributed to the acute glomerular injury observed in the patient.
Article
Pediatrics
Fatina Fadel, Hafez M. Bazaraa, Mohamed A. Abdel Mawla, Doaa M. Salah
Summary: This study investigated the outcomes of kidney transplantation in children with FSGS secondary to ESKD, finding favorable results with perioperative PE for non-genetically proven cases and successful management of early recurrence with PE and RTX. There was no significant difference in renal function and proteinuria levels between sporadic patients who received prophylactic perioperative PE and genetic/familial patients.
ITALIAN JOURNAL OF PEDIATRICS
(2021)
Article
Urology & Nephrology
Hye Eun Kwon, Young Hoon Kim, Sang Ah Lee, Jae Jun Lee, Youngmin Ko, Sung Shin, Joo Hee Jung, Frances S. S. Sung, Chung Hee Baek, Hyosang Kim, Su-Kil Park, Hyunwook Kwon
Summary: Recurrent FSGS after kidney transplantation is a serious complication and a significant risk factor for graft failure. The effectiveness of pre-transplant treatment using plasmapheresis or rituximab in preventing post-operative FSGS recurrence after KT is still unclear.
Article
Urology & Nephrology
Yingchao Peng, Tao Ju, Chunlin Gao, Zhengkun Xia, Meiqiu Wang, Xiaoyi Sun, Ren Wang, Xiaojie Li, Yaqin Wei, Lili Jia, Huangyu Chen
Summary: This study aimed to investigate the clinical and prognostic relevance of C1q nephropathy in pediatric patients with primary focal segmental glomerulosclerosis. It was found that C1q nephropathy was rare in children and showed poor response to steroids. The long-term renal outcomes and remission rates were comparable between children with and without C1q nephropathy.
JOURNAL OF NEPHROLOGY
(2023)
Article
Medicine, General & Internal
Hisashi Sugimoto, Naoki Sawa, Hajime Yamagiwa, Masahiro Kawada, Daisuke Ikuma, Yuki Oba, Hiroki Mizuno, Akinari Sekine, Masayuki Yamanouchi, Eiko Hasegawa, Tatsuya Suwabe, Aya Nishida, Kei Kono, Keiichi Kinowaki, Kenichi Ohashi, Yutaka Yamaguchi, Yoshifumi Ubara
Summary: A 72-year-old man with proteinuria and leg edema was diagnosed with essential thrombocythemia (ET), identified by thrombocytosis, elevated megakaryocytes, and JAK2 V617 mutation. Kidney biopsy revealed focal segmental glomerulosclerosis (FSGS) cellular variant and other FSGS variants, with positive megakaryocyte infiltrations. ET may cause FSGS by increasing intraglomerular pressure due to megakaryocyte infiltration.
Article
Medicine, General & Internal
Wenqiang Zhi, Xiaoli Yuan, Wenzhu Song, Guorong Jin, Yafeng Li
Summary: This is the first report of fecal microbiota transplantation (FMT) in patients with chronic kidney disease. The patient experienced abnormal renal function and no proteinuria after medication, but FMT treatment stabilized renal function and reduced proteinuria. Additionally, FMT improved the patient's lipid profile.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Urology & Nephrology
Ke Sun, Qionghong Xie, Chuan-Ming Hao
Summary: This study focuses on the potential sources and mechanism of podocyte supplementation in FSGS. Parietal epithelial cells (PECs) have gained attention for their role in the progression of FSGS, as both influencing factors in glomerulosclerosis lesions and their repair abilities are being debated. Other resident glomerular cells are also significant in the progression of the disease.
Article
Urology & Nephrology
Jiang Bai, Tianxiang Zhang, Yan Wang, Jiajing Cao, Zihui Duan, Linghui Ji, Yun Zhou, Chuan Hao, Qiang Guo
Summary: This study systematically reviewed the incidence and risk factors for recurrent FSGS after kidney transplantation. The results showed that the recurrence rate of FSGS after kidney transplantation was 38%. Age, original disease progression, proteinuria, related donor, and nephrectomy of native kidneys were associated with recurrent FSGS.
Article
Chemistry, Multidisciplinary
Qiong-Dan Hu, Hong-Lian Wang, Jian Liu, Tao He, Rui-Zhi Tan, Qiong Zhang, Hong-Wei Su, Fahsai Kantawong, Hui-Yao Lan, Li Wang
Summary: Btg2 plays a pathogenic role in FSGS by promoting podocyte injury through a Smad3-dependent epithelial-mesenchymal transition pathway.