Article
Neurosciences
Nirvana Sadaghianloo, Julie Contenti, Serge Declemy, Damien Ambrosetti, Masa Zdralevic, Mounia Tannour-Louet, Lucilla Fabbri, Gilles Pages, Frederic Bost, Reda Hassen-Khodja, Jacques Pouyssegur, Elixene Jean-Baptiste, Alan Dardik, Nathalie M. Mazure
Summary: Patients with end-stage renal failure need AVFs for dialysis, but these AVFs often fail due to excessive venous thickness. This study found that venous cells adapt their metabolism depending on oxygen concentration, and targeting the hypoxic response pathway with drugs can help decrease excessive venous thickness. In a mouse model, inhibiting HIFs decreased neointimal hyperplasia, suggesting that drugs targeting HIFs could prevent AVF failure.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Biotechnology & Applied Microbiology
Xinlong Xie, Qiying Wu, Yuhong Liu, Chunyang Chen, Zeguo Chen, Chao Xie, Mingzhe Song, Zhenlin Jiang, Xiaoke Qi, Sixi Liu, Zhenjie Tang, Zhongshi Wu
Summary: This study evaluated the effect of VEGF on neointimal hyperplasia and local inflammatory responses in decellularized small-diameter vascular grafts. The results showed that local administration of VEGF attenuated neointimal hyperplasia by inducing macrophage M2 polarization and modulating the inflammatory response.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Allan John R. Barcena, Joy Vanessa D. Perez, Olivia Liu, Amy Mu, Francisco M. Heralde, Steven Y. Huang, Marites P. Melancon
Summary: Arteriovenous fistula (AVF) is the preferred vascular access for chronic hemodialysis, but its high failure rates limit its use. Neointimal hyperplasia (NIH) is a predominant cause of AVF failure, and systemic therapies have not shown clear benefits. Localized therapeutic approaches can improve AVF maturation rates by providing structural and functional support, as well as by delivering higher doses of drugs without systemic adverse effects.
Article
Medicine, Research & Experimental
Yanhua Xu, Zhiju Wang, Shunbo Wei, Peng Sun, Hualong Bai, Jing'an Li
Summary: Hydrogel-coated needles effectively stopped bleeding in rat AVF and AVG models, showing potential for clinical application. Additional clinical studies are needed to further validate its effectiveness.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Boao Xie, Liwei Zhang, Chunyang Lou, Shunbo Wei, Jing'an Li, Hualong Bai, Alan Dardik
Summary: The study found that wood can be used as a vascular patch material and can improve drug delivery. These plant-derived materials may serve as alternatives to prosthetic or animal-based materials in vascular applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yu-Chun Chang, Junlang Li, Gabriel Mirhaidari, Jacob Zbinden, Jenny Barker, Kevin Blum, James Reinhardt, Cameron Best, John Kelly, Toshihiro Shoji, Tai Yi, Christopher Breuer
Summary: Zoledronate treatment in tissue-engineered vascular grafts (TEVGs) showed a positive effect on neotissue formation, reduced macrophage infiltration, and affected collagen deposition. It may offer a potential approach to mitigate TEVG stenosis.
Article
Surgery
Rueshil Fadia, Scott S. Berman, Chyi Chyi Chong, Denis Rybin, Jeffrey J. Siracuse, Wei Zhou, Tze-Woei Tan
Summary: This study compared the outcomes of forearm AVGs and upper arm brachial artery AVGs, showing that the primary and secondary patency rates were superior for upper arm AVGs. However, forearm AVGs had a higher risk of loss of primary and secondary patency at 12 months.
ANNALS OF VASCULAR SURGERY
(2021)
Article
Peripheral Vascular Disease
Saeed Saad Alqahtani, Marije Sloff, Pamir Sawo
Summary: This study developed a new polyurethane graft for hemodialysis patients using electrospinning and chemical modifications. The results showed that animals with polyurethane grafts had better blood flow and minimal neointimal hyperplasia compared to the control group.
JOURNAL OF VASCULAR ACCESS
(2022)
Article
Urology & Nephrology
Chi-Jen Chang, Ying-Ju Lai, Ying-Chang Tung, Lung-Sheng Wu, Lung-An Hsu, Chi-Nan Tseng, Gwo-Jyh Chang, Kai-Chien Yang, Yung-Hsin Yeh
Summary: Our study suggests that disturbed flow in dysfunctional arteriovenous fistulae (AVF) contributes to the development of neointimal hyperplasia (NH) through the induction of endothelial mesenchymal transition (EndMT) via the osteopontin/CD44 axis. We provided evidence from both animal and cell culture experiments to support this hypothesis. We also found that the osteopontin/CD44 axis is involved in AVF dysfunction in patients with uremia. These findings highlight the potential of targeting the osteopontin/CD44 axis as a therapeutic strategy for preventing AVF dysfunction.
KIDNEY INTERNATIONAL
(2023)
Article
Engineering, Biomedical
Maheshika Somarathna, Patrick TJ. Hwang, Reid C. Millican, Grant C. Alexander, Tatyana Isayeva-Waldrop, Jennifer A. Sherwood, Brigitta C. Brott, Isabelle Falzon, Hannah Northrup, Yan-Ting Shiu, Chris J. Stubben, John Totenhagen, Ho-Wook Jun, Timmy Lee
Summary: The study found that nitric oxide plays an important regulatory role in AVF development, but there are currently no effective treatments to prevent AVF maturation failure. By using a self-assembled NO releasing nanomatrix gel, intimal hyperplasia formation can be inhibited, and vascular outward remodeling and hemodynamic adaptation can be improved, thereby enhancing AVF development. This research is crucial for providing long-term and durable vascular access for hemodialysis patients.
Review
Peripheral Vascular Disease
Roberto Vazquez-Padron, Laisel Martinez, Juan C. Duque, Loay H. Salman, Marwan Tabbara
Summary: Neointimal cells in arteriovenous fistula (AVF) have uncertain origins and play a significant role in intimal expansion. Understanding their sources is important for developing therapies to reduce intimal hyperplasia, and for clarifying cellular dynamics during postoperative remodeling.
JOURNAL OF VASCULAR ACCESS
(2023)
Article
Computer Science, Interdisciplinary Applications
Jose A. Rosado-Toro, Rohit C. Philip, Samuel Thomas Dunn, Diego Celdran-Bonafonte, Yong He, Scott A. Berceli, Prabir Roy-Chaudhury, Eleonora Tubaldi
Summary: A software protocol for the functional analysis of arteriovenous fistula (AVF) has been developed, which utilizes anatomical analysis and magnetic resonance imaging (MRI) to better understand and predict the causes of AVF maturation failure, providing individualized treatment options for dialysis vascular access.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Materials Science, Biomaterials
Lu Yu, Emily R. Newton, David C. Gillis, Kui Sun, Brian C. Cooley, Andrew N. Keith, Sergei S. Sheiko, Nick D. Tsihlis, Melina R. Kibbe
Summary: The study focuses on developing POCA elastomers with tunable properties for coating small-diameter ePTFE vascular grafts to inhibit neointimal hyperplasia. By increasing surface ascorbate density and adjusting coating number, significant reduction in neointimal hyperplasia was observed, demonstrating promising potential for vascular engineering.
BIOMATERIALS SCIENCE
(2021)
Article
Urology & Nephrology
Avishek K. Singh, Chuanqi Cai, Sreenivasulu Kilari, Chenglei Zhao, Michael L. Simeon, Edwin Takahashi, Elazer R. Edelman, Hyunjoon (Joon) Kong, Thanila Macedo, Ravinder J. Singh, Matthew W. Urban, Rajiv Kumar, Sanjay Misra
Summary: The study shows that local release of 1,25 NP from PLGA nanoparticles can reduce VNH/VS formation in AVFs, and decrease inflammation, apoptosis, and fibrosis.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Dan Shan, Ping Qu, Chao Zhong, Luling He, Qingshan Zhang, Guoyue Zhong, Wenhui Hu, Yulin Feng, Shilin Yang, Xiao-feng Yang, Jun Yu
Summary: This study identified Anemoside B4 as a potential therapeutic agent that regulates vascular smooth muscle cell plasticity and inhibits restenosis after vascular intervention.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)