Journal
ADVANCES IN CHRONIC KIDNEY DISEASE
Volume 15, Issue 4, Pages 413-419Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.ackd.2008.07.011
Keywords
Vascular calcification; Uremia; Chronic kidney disease; Vascular disease; Tumor necrosis factor alpha; Metabolic acidosis
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Arterial calcification is very common in patients with chronic kidney disease (CKD) and other chronic inflammatory discorders such as diabetes mellitus. Arterial calcification is associated with significant morbidity and increased early mortality. Vascular calcification is a highly orchestrated process that entrains a repertoire of transcription factors and involves the activation of an osteogenic program that recapitulates the molecular fingerprints seen in bone formation. Recent studies have implicated the inflammatory cytokine tumor necrosis factor a in the pathobiology of arterial calcification. Metabolic acidosis, which is prevalent in patients with advanced kidney disease, has also been shown in some recent studies to attenuate vascular calcification in animal models. In this review, we summarize the recent advances in understanding the molecular mechanisms underpinning vascular mineralization and discuss their implications in terms of translational opportunities, unmet needs, and future directions. Published by Elsevier Inc.
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