Article
Medical Laboratory Technology
Zhimin Huang, Lin Wu, Ming Zeng, Buyun Wu, Xueqiang Xu, Huijuan Mao, Yanggang Yuan, Changying Xing
Summary: This study aimed to evaluate the ability of neutrophil gelatinase-associated lipocalin (NGAL) in differentiating acute kidney injury (AKI) from chronic kidney disease (CKD). The results showed that urinary NGAL (uNGAL) levels were significantly higher in the AKI group compared to the CKD group, while serum NGAL (sNGAL) levels were not significantly different. Furthermore, the u/s NGAL ratio and fractional excretion of NGAL (Fe NGAL) were able to effectively distinguish AKI from CKD. Further confirmatory studies are still necessary.
CLINICA CHIMICA ACTA
(2022)
Article
Medical Laboratory Technology
Ze-Liang Qiu, Bi-Qing Yan, Rui Zhao, Dong-Wei Xu, Kan Shen, Xing-Qi Deng, Shi-Qi Lu
Summary: This study aimed to assess the early predictive values of hepcidin, NGAL, and their combination for secondary AKI in patients with sepsis. Results indicated that higher serum hepcidin and urine NGAL levels at admission were independent predictors of AKI development in critically septic patients. Serum hepcidin and urine NGAL were comparable predictive indicators of AKI occurrence, with their combination showing improved accuracy in prediction.
CLINICA CHIMICA ACTA
(2021)
Article
Gastroenterology & Hepatology
Roshan George, Ujjwal Sonika, Bhawna Mahajan, Ashok Sharma, Ashok Dalal, Sanjeev Sachdeva, Ajay Kumar
Summary: This study compared the diagnostic accuracy of urine neutrophil gelatinase-associated lipocalin (UNGAL) and renal resistive index (RRI) in predicting the type of acute kidney injury (AKI) in decompensated cirrhosis (DC) patients. The results showed that UNGAL has an excellent diagnostic accuracy in predicting ATN-AKI.
DIGESTIVE AND LIVER DISEASE
(2023)
Review
Critical Care Medicine
Heng-Chih Pan, Shao-Yu Yang, Terry Ting-Yu Chiou, Chih-Chung Shiao, Che-Hsiung Wu, Chun-Te Huang, Tsai-Jung Wang, Jui-Yi Chen, Hung-Wei Liao, Sheng-Yin Chen, Tao-Min Huang, Ya-Fei Yang, Hugo You-Hsien Lin, Ming-Jen Chan, Chiao-Yin Sun, Yih-Ting Chen, Yung-Chang Chen, Vin-Cent Wu
Summary: This study compared the predictive performance of different biomarkers for acute kidney injury (AKI). The biomarkers containing NGAL showed the best predictive accuracy for the occurrence of AKI, especially in medically treated patients. However, the predictive performance of urinary NGAL was limited in surgical patients, and urinary NGAL/creatinine seemed to be the most accurate biomarkers in these patients. All of the biomarkers had similar predictive performance in critically ill patients.
Article
Urology & Nephrology
Stuart L. Goldstein, Kelli A. Krallman, Cassie Kirby, Jean-Philippe Roy, Michaela Collins, Kaylee Fox, Alexandra Schmerge, Sarah Wilder, Bradley Gerhardt, Ranjit Chima, Rajit K. Basu, Lakhmir Chawla, Lin Fei
Summary: Acute kidney injury is common among children and young adults admitted to the pediatric intensive care unit, and severe acute kidney injury is associated with mortality. The integration of renal angina index and urine NGAL improves the prediction of severe acute kidney injury.
KIDNEY INTERNATIONAL REPORTS
(2022)
Review
Pediatrics
Ibrahim Sandokji, Jason H. Greenberg
Summary: This article reviews the literature on commonly evaluated biomarkers of acute kidney injury (AKI) in the last 2 years and highlights the findings of these biomarkers. Among several studied AKI biomarkers, urine neutrophil gelatinase-associated lipocalin (NGAL) and the combination of urine tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor binding protein 7 (IGFBP7) have been most frequently studied as diagnostic biomarkers of AKI and for AKI risk stratification. Urine NGAL continues to show good discriminative value in predicting and diagnosing AKI in children, while urine TIMP-2*IGFBP7 provides modest improvement to clinical models of AKI.
CURRENT OPINION IN PEDIATRICS
(2023)
Article
Medicine, General & Internal
David Zahler, Ilan Merdler, Ariel Banai, Eden Shusterman, Omri Feder, Tamar Itach, Leemor Robb, Shmuel Banai, Yacov Shacham
Summary: Elevated NGAL levels have prognostic utility for renal and clinical outcomes among STEMI patients undergoing primary PCI, independent of traditional inflammatory markers. High NGAL is associated with increased short-term adverse outcomes, such as acute kidney injury, lower left ventricular ejection fraction, higher 30-day mortality, and higher incidence of MACE.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Xiao-Wen Zhen, Nian-Peng Song, Lian-Huan Ma, Li-Na Ma, Ling Guo, Xiang-Dong Yang
Summary: This study found that plasma calprotectin and NGAL levels were significantly higher in ACS patients with AKI compared to those without AKI. These two biomarkers could early discriminate AKI in ACS patients and a combination of them showed even better diagnostic performance.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2021)
Review
Medicine, Research & Experimental
Zuoxiu Xiao, Qiong Huang, Yuqi Yang, Min Liu, Qiaohui Chen, Jia Huang, Yuting Xiang, Xingyu Long, Tianjiao Zhao, Xiaoyuan Wang, Xiaoyu Zhu, Shiqi Tu, Kelong Ai
Summary: This review summarizes the application and progress of machine learning and emerging detection technologies in the early diagnosis of acute kidney injury (AKI). Early diagnosis is crucial for preventing the progression of AKI to chronic renal failure.
Review
Medicine, General & Internal
Chunhua Xu, Shan Lin, Longyi Mao, Zesong Li
Summary: NGAL levels in plasma/serum and urine perform well in predicting AKI requiring RRT, suggesting it as an effective predictive biomarker. Further research is needed for improved patient outcomes.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Ariel Banai, Shir Frydman, Hytham Abu Katash, Moshe Stark, Ilana Goldiner, Shmuel Banai, Yacov Shacham
Summary: This study investigated the incidence and implications of acute kidney injury (AKI) phenotypes in ST elevation myocardial infarction patients treated with primary coronary intervention. The results showed that AKI is a heterogeneous condition, and the addition of new biomarkers may improve the definition of AKI phenotypes and guide potential therapies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Agriculture, Dairy & Animal Science
Barbara Bruno, Roberta Troia, Francesco Dondi, Cristiana Maurella, Paola Gianella, Ilaria Lippi, Alberto Tarducci, Antonio Borrelli
Summary: This study evaluated the effects of constant rate infusion of HES 130/0.4 on renal biomarkers in dogs. The results indicated that in hypoalbuminemic dogs, the dose and rate of HES infusion did not lead to significant changes in the investigated biomarkers of kidney injury. Further prospective studies are needed to assess the renal safety profile of low-molecular-weight HES administration in more severely affected dogs.
Article
Physiology
Christopher L. L. Chapman, Sadie M. M. Holt, Cameron T. T. O'Connell, Shaun C. C. Brazelton, William A. B. Howells, Hannah N. N. Medved, Emma L. L. Reed, Karen Wiedenfeld Needham, John R. R. Halliwill, Christopher T. T. Minson
Summary: The high prevalence of inadequate hydration is concerning and may have negative health impacts. This study found that prolonged mild hypohydration increased a urinary biomarker associated with kidney injury. Urine osmolality and urine specific gravity showed high accuracy in identifying individuals at risk of acute kidney injury.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2023)
Article
Medicine, General & Internal
Yuwei Yang, Bin Ge, Yan Liu, Jiafu Feng
Summary: This study investigates the roles of NGAL, CysC, and sCr in diagnosing AKI secondary to liver cirrhosis. Results suggest that NGAL may outperform sCr and CysC, with uNGAL being a more reliable indicator for diagnosing AKI.
Article
Urology & Nephrology
Insa M. Schmidt, Anand Srivastava, Venkata Sabbisetti, Gearoid M. McMahon, Jiang He, Jing Chen, John W. Kusek, Jonathan Taliercio, Ana C. Ricardo, Chi-yuan Hsu, Paul L. Kimmel, Kathleen D. Liu, Theodore E. Miff, Robert G. Nelson, Ramachandran S. Vasan, Dawei Xie, Xiaoming Zhang, Ragnar Palsson, Isaac E. Stillman, Helmut G. Rennke, Harold I. Feldman, Joseph V. Bonventre, Sushrut S. Waikar
Summary: Plasma KIM-1 levels are associated with clinical outcomes and pathological lesions in various kidney diseases, with higher levels of plasma KIM-1 being linked to an increased risk of kidney failure.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Article
Pediatrics
Hermine I. Brunner, Gaurav Gulati, Marisa S. Klein-Gitelman, Kelly A. Rouster-Stevens, Lori Tucker, Stacey P. Ardoin, Karen B. Onel, Rylie Mainville, Jessica Turnier, Pinar Ozge Avar Aydin, David Witte, Bin Huang, Michael R. Bennett, Prasad Devarajan
PEDIATRIC NEPHROLOGY
(2019)
Article
Pediatrics
Shannon L. Carpenter, Jennifer Goldman, Ashley K. Sherman, David T. Selewski, Mahmoud Kallash, Cheryl L. Tran, Meredith Seamon, Chryso Katsoufis, Isa Ashoor, Joel Hernandez, Katarina Supe-Markovina, Cynthia D'alessandri-Silva, Nilka DeJesus-Gonzalez, Tetyana L. Vasylyeva, Cassandra Formeck, Christopher Woll, Rasheed Gbadegesin, Pavel Geier, Prasad Devarajan, William E. Smoyer, Bryce A. Kerlin, Michelle N. Rheault
PEDIATRIC NEPHROLOGY
(2019)
Article
Rheumatology
Jessica L. Turnier, Hermine I. Brunner, Michael Bennett, Ashwaq Aleed, Gaurav Gulati, Wendy D. Haffey, Sherry Thornton, Michael Wagner, Prasad Devarajan, David Witte, Kenneth D. Greis, Bruce Aronow
Review
Biochemical Research Methods
Najla Aljaberi, Michael Bennett, Hermine I. Brunner, Prasad Devarajan
EXPERT REVIEW OF PROTEOMICS
(2019)
Review
Urology & Nephrology
Beatriz Desanti De Oliveira, Katherine Xu, Tian H. Shen, Miriam Callahan, Krzysztof Kiryluk, Vivette D. D'Agati, Nicholas P. Tatonetti, Jonathan Barasch, Prasad Devarajan
NATURE REVIEWS NEPHROLOGY
(2019)
Review
Pediatrics
Jean-Philippe Roy, Prasad Devarajan
INDIAN JOURNAL OF PEDIATRICS
(2020)
Article
Urology & Nephrology
Saban Elitok, Prasad Devarajan, Rinaldo Bellomo, Berend Isermann, Michael Haase, Anja Haase-Fielitz
Summary: The study aimed to investigate the prognostic value of AKI subtypes defined by the NGAL/hepcidin-25 ratio in higher-risk cardiac surgery patients. Results showed that subclinical and combined AKI patients had significantly higher in-hospital mortality rates, indicating a strong association between these biomarker-informed AKI subtypes and prognosis.
JOURNAL OF NEPHROLOGY
(2022)
Article
Medicine, Research & Experimental
Saban Elitok, Berend Isermann, Sabine Westphal, Prasad Devarajan, Christian Albert, Hermann Kuppe, Martin Ernst, Rinaldo Bellomo, Michael Haase, Anja Haase-Fielitz
Summary: In a pilot study with 100 adult patients after cardiac surgery, urinary biomarkers, but not blood biomarkers, were found to be able to predict postoperative severe fluid overload.
BIOMARKERS IN MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Naomi Pode-Shakked, Prasad Devarajan
Summary: Acute kidney injury (AKI) is a common and serious problem affecting people of all ages, with a lack of understanding in its pathobiology hindering the development of new diagnostics and therapeutics. Recent advancements in using human stem cells, organoids, and in silico approaches have been made in studying human AKI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pediatrics
William DeFoor, Edward Nehus, Marion Schulte, Sydney Huesman, Ashleigh Libs, Renee Niehaus, Prasad Devarajan
Summary: The purpose of this study is to determine risk factors for recurrent stone formation in non-ambulatory children. The study found that urinary oxalate excretion is significantly increased in these patients, while urinary calcium excretion is similar to healthy controls. Further research and dietary intervention are needed to reduce stone formation.
JOURNAL OF PEDIATRIC UROLOGY
(2022)
Article
Pediatrics
Ellen M. Cody, Scott E. Wenderfer, Kathleen E. Sullivan, Alfred H. J. Kim, Wesley Figg, Harneet Ghumman, Tingting Qiu, Bin Huang, Prasad Devarajan, Hermine Brunner
Summary: The Renal Activity Index for Lupus (RAIL) can non-invasively identify lupus nephritis (LN) and assess the efficacy of LN induction therapy. RAIL scores can differentiate clinically active LN from inactive LN or without LN. RAIL scores significantly decrease after complete LN remission.
PEDIATRIC NEPHROLOGY
(2023)
Article
Urology & Nephrology
Hillarey K. Stone, Bin Huang, Chen Chen, Qing Ma, Michael R. Bennett, Prasad Devarajan
Summary: The study validates a urinary biomarker risk score to predict steroid resistance in adult patients with nephrotic syndrome at initial diagnosis. The risk score showed optimal sensitivity and specificity in distinguishing steroid sensitive from resistant individuals, with an AUC of 0.79.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Physiology
Denise C. Hasson, Miki Watanabe-Chailland, Lindsey Romick-Rosendale, Adeleine Koterba, Dashiell S. Miner, Patrick Lahni, Qing Ma, Stuart L. Goldstein, Prasad Devarajan, Stephen W. Standage
Summary: This study found that altered choline metabolism is involved in sepsis-associated acute kidney injury (SA-AKI) in both humans and mice, and choline administration improved renal function in experimental SA-AKI. These findings suggest that mouse models can help in investigating clinically relevant mechanisms and that choline supplementation may ameliorate SA-AKI in humans.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Article
Urology & Nephrology
Kenneth Lieberman, Alexander R. Chang, Geoffrey A. Block, Kristina Robinson, Sara L. Bristow, Ana Morales, Asia Mitchell, Stephen McCalley, Jim McKay, Martin R. Pollak, Swaroop Aradhya, Bradley A. Warady
Summary: This study evaluated the diagnostic yield and phenotypic spectrum of CKD in individuals tested through a genetic testing program, showing the importance of genetic testing in diagnosing CKD and identifying related gene abnormalities.
Article
Physiology
Stephanie L. K. Bowers, Stephanie Davis-Rodriguez, Zachary M. Thomas, Valeria Rudomanova, W. Clark Bacon, Alex Beiersdorfer, Qing Ma, Prasad Devarajan, Burns C. Blaxall
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2019)
