Article
Oncology
Qigen Fang, Yao Wu, Wei Du, Xu Zhang, Defeng Chen
Summary: The expression of PD-L1 in high-grade salivary gland carcinomas was significantly associated with tumor stage, and a tumor proportion score (TPS) of >= 1% was common in 43.1% of patients, with significant differences in 5-year disease-free survival and overall survival rates.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Naruhiko Morita, Takayuki Murase, Kaori Ueda, Toshitaka Nagao, Kimihide Kusafuka, Masato Nakaguro, Makoto Urano, Ken-ichi Taguchi, Hidetaka Yamamoto, Satoshi Kano, Yuichiro Tada, Kiyoaki Tsukahara, Kenji Okami, Tetsuro Onitsuka, Yasushi Fujimoto, Daisuke Kawakita, Kazuo Sakurai, Toru Nagao, Nobuhiro Hanai, Ryo Kawata, Naohito Hato, Naoki Otsuki, Ken-ichi Nibu, Hiroshi Inagaki
Summary: The study introduces the minAmax system as a simple, objective, and highly reproducible grading system useful for prognostic stratification in salivary AdCC. After a central pathology review of AdCC cases, it was found that the minAmax system and van Weert system were independent prognostic tools.
Review
Health Care Sciences & Services
Maria Menini, Emanuele De Giovanni, Francesco Bagnasco, Francesca Delucchi, Francesco Pera, Domenico Baldi, Paolo Pesce
Summary: Salivary miRNAs show potential as diagnostic and prognostic biomarkers for oral squamous cell carcinoma, providing a non-invasive and cost-effective method for diagnosis and aiding in monitoring disease progression and treatment response.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Oncology
Carolina Emerick, Fernanda Viviane Mariano, Pablo Agustin Vargas, Jacques E. Nor, Cristiane H. Squarize, Rogerio M. Castilho
Summary: Adenoid cystic carcinoma (ACC) is a malignant lesion that can occur in various anatomical sites. ACC in salivary and lacrimal glands has a high risk of invasion and metastasis, while ACC in the breast is rarer and less aggressive. Perineural invasion is a major predictor of mortality in ACC, and the prognosis differs between different anatomical sites. The genetic variations and prognostic differences of ACC are still not well understood, but there are available treatments and emerging strategies being developed.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Article
Cell Biology
Bin Xu, Kartik Viswanathan, Kavita Umrau, Thair A. D. Al-Ameri, Snjezana Dogan, Kelly Magliocca, Ronald A. Ghossein, Nicole A. Cipriani, Nora Katabi
Summary: This large retrospective study aimed to identify adverse clinicopathologic factors of the rare form of salivary carcinoma, secretory carcinoma (SC), and propose a prognostically relevant grading system. The proposed grading system can assist in risk stratification and appropriate clinical management of SC patients.
Article
Oncology
Samuel Rack, Laura Feeney, Brindley Hapuarachi, Helen Adderley, Laura Woodhouse, Guy Betts, George J. Burghel, Kevin J. Harrington, Robert Metcalf
Summary: Salivary gland cancer is rare and new drugs are being developed to target specific changes within the cancer. Through DNA sequencing, one in four patients with salivary gland cancer were matched to drug therapies. Different gene panels showed varying levels of usefulness in matching patients to trial therapies.
Article
Oncology
Shuiqing He, Danjie He, Jiaxin Li, Hongwei Yu, Shoumin Bai, Cheng Xu, Ying Huang
Summary: This study aimed to explore prognostic factors and the role of postoperative radiotherapy (PORT) in patients with lymphoepithelial carcinoma of the salivary glands (LECSG). The study found that the number of positive lymph nodes (PLNs) >= 3 and tumor size >= 3 cm were independent factors for PFS in patients with neck dissection (ND). Additionally, detectable EBV DNA after surgery was a negative prognostic factor.
RADIOTHERAPY AND ONCOLOGY
(2023)
Review
Oncology
Conor E. Steuer, Glenn J. Hanna, Kartik Viswanathan, James E. Bates, Azeem S. Kaka, Nicole C. Schmitt, Alan L. Ho, Nabil F. Saba
Summary: Salivary gland cancers are rare and histologically diverse tumors that can range from indolent to aggressive, causing significant morbidity and mortality. Surgical resection is the main treatment, but radiation and systemic therapy are also critical. Due to their rarity and heterogeneity, a multidisciplinary approach is best for managing these cancers. This review highlights current standards of care and exciting new research aiming to improve patient outcomes for salivary gland cancers.
CA-A CANCER JOURNAL FOR CLINICIANS
(2023)
Article
Veterinary Sciences
Kayla Alexander, Jennifer Beam, Brittany Baughman, Timothy W. W. Morgan
Summary: Salivary gland neoplasia is rare in cattle, and this study presents a case of high-grade mucoepidermoid carcinoma in a bull. Clinical and postmortem findings supported the diagnosis.
JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION
(2023)
Review
Oncology
Marco Bocchetti, Piera Grisolia, Federica Melisi, Maria Grazia Ferraro, Pietro De Luca, Angelo Camaioni, Michela Falco, Marianna Abate, Gabriella Misso, Roberto Alfano, Nunzio Accardo, Flavia Oliva, Alessia Maria Cossu, Michele Caraglia, Marianna Scrima, Filippo Ricciardiello
Summary: Salivary gland cancer (SGC) is a rare and heterogeneous disease with unclear mechanisms of development and progression. Recent studies have found that microRNAs could potentially serve as prognostic and diagnostic markers for SGC, aiding clinicians in early diagnosis and treatment strategies.
Review
Biochemistry & Molecular Biology
Malin Tordis Meyer, Christoph Watermann, Thomas Dreyer, Sueleyman Erguen, Srikanth Karnati
Summary: Salivary gland tumors consist of both malignant and benign tumors, with the most common malignant tumors being mucoepidermoid carcinoma, adenoid cystic carcinoma, and acinic cell carcinoma, and the most common benign tumor being pleomorphic adenoma. Due to their low incidence rates and complex histological patterns, diagnosing salivary gland tumors accurately can be challenging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Lygia Sega Nogueira, Carolina P. Vasconcelos, Jessica Rodrigues Placa, Geovanni Pereira Mitre, Leonardo Oliveira Bittencourt, Maria Sueli da Silva Kataoka, Edivaldo H. C. de Oliveira, Rafael Rodrigues Lima
Summary: The study aims to investigate the gene expression changes in human salivary gland cells after exposure to MeHg through transcriptome analysis. The results showed that MeHg altered the expression of 155 genes, with upregulated genes mainly related to cell-cycle progression, DNA repair, and GSH basal metabolism, while downregulated genes were associated with impaired cell metabolism.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Dentistry, Oral Surgery & Medicine
Brendo Vinicius Rodrigues Louredo, Alan Roger Santos-Silva, Pablo Agustin Vargas, Marcio Ajudarte Lopes, Manoela Domingues Martins, Eliete Neves da Silva Guerra, Ana Carolina Prado Ribeiro, Thais Bianca Brandao, Regina Maria Holanda de Mendonca, Luiz Paulo Kowalski, Paul M. Speight, Syed Ali Khurram, Maria Eduarda Perez-de-Oliveira
Summary: This study evaluated the clinicopathological profile and survival outcomes of pediatric patients affected by salivary gland tumors, revealing a high frequency of malignant tumors in these patients, with surgery being the main treatment choice and a high overall survival rate for the patients.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2021)
Article
Otorhinolaryngology
Yujiao Li, Chaosu Hu
Summary: Lower T or N classification and highly differentiated disease were associated with a significantly lower risk of lung metastases in patients with major salivary gland mucoepidermoid carcinoma (MaSG-MEC). Elderly Caucasian male patients with poorly differentiated disease, multiple sites of metastases and no surgical therapy to primary tumor were more likely to reduce life expectancy.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Oncology
Florian Chatelet, Francois Regis Ferrand, Sarah Atallah, Juliette Thariat, Francois Mouawad, Nicolas Fakhry, Olivier Malard, Caroline Even, Erwan de Mones, Emmanuelle Uro-Coste, Nazim Benzerdjeb, Stephane Hans, Sylvie Testelin, Olivier Mauvais, Diane Evrard, Vianney Bastit, Sebastien Salas, Florent Espitalier, Marion Classe, Laurence Digue, Melanie Dore, Stephanie Wong, Charles Dupin, France Nguyen, Jeremie Bettoni, Ariane Lapierre, Emilien Colin, Pierre Philouze, Sebastien Vergez, Bertrand Baujat, Philippe Herman, Benjamin Verillaud
Summary: This study analyzed data from the national REFCOR multi-center cohort to investigate the prognostic factors in acinic cell carcinomas (AciCCs) and assess the impact of postoperative radiotherapy and prophylactic neck dissection. The results suggest the importance of long-term follow-up in AciCC patients and indicate that surgery alone may be an option for selected patients without high-grade transformation. Prophylactic neck dissection may be beneficial for patients with advanced stage or high-grade tumors.
EUROPEAN JOURNAL OF CANCER
(2023)