Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 360, Issue 23, Pages 4634-4639Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201801080
Keywords
Asymmetric allenylation; Phosphoric acid; Allenic alcohols
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Funding
- Auburn University
- Merner and Gordon groups at Auburn University
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An enantioselective allenylation of aldehydes catalyzed by a chiral, nonracemic phosphoric acid was reported. Under the developed conditions, 1,1 '-disubstituted allenic alcohols were obtained in 64-98% yields with 88-99% ee. Computational studies were conducted to probe the origin of asymmetric induction. Mechanistic studies suggest that the pinacol moiety of the propargylboronate is critical to the enantioselectivity of the reaction that was supported by experimental data.
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