Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 360, Issue 17, Pages 3220-3227Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201800531
Keywords
C-N bond formation; Hydrogen evolution; C-H amination; Photoredox catalysis; Synergetic catalysis
Categories
Funding
- National Natural Science Foundation of China [21390402, 21520102003, 21272180]
- Natural Science Foundation of Hubei Province [2016CFB571]
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In this work, we achieved a site-selective amination of 2-arylimidazoheterocycles on the C3 position using photo-induced external oxidant-free strategy. The C-N bond formation with H-2 evolution was realized via the oxidative C-H/N-H coupling. This protocol may have significant implications in the late-modification of complicated drug molecules. In addition, we also used CV and DFT calculations to study the mechanism, which showed that the arene radical cation played an important role in accelerating the C-H amination process.
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