Article
Allergy
Amanda K. Rudman Spergel, Michelle L. Sever, Jacqueline Johnson, Michelle A. Gill, Veronique Schulten, April Frazier, Carolyn M. Kercsmar, Stephanie Lovinsky-Desir, Dan A. Searing, Alessandro Sette, Baomei Shao, Stephen J. Teach, James E. Gern, William W. Busse, Alkis Togias, Robert A. Wood, Andrew H. Liu
Summary: This study identified a range of German cockroach extract doses that induce nasal symptoms and assessed the safety of cockroach NAC in children with asthma. NAC could be considered as a tool to confirm clinically relevant sensitization and assess responses in therapeutic studies.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Allergy
Almudena Testera-Montes, Francisca Palomares, Raquel Jurado-Escobar, Ruben Fernandez-Santamaria, Adriana Ariza, Jesus Verge, Maria Salas, Paloma Campo, Cristobalina Mayorga, Maria Jose Torres, Carmen Rondon, Ibon Eguiluz-Gracia
Summary: This study found that nasal allergen exposure can induce an increase in allergen-specific IgE-producing cells in the nasal mucosa of allergic rhinitis patients, as well as similar changes in peripheral blood. These findings reveal the mechanisms underlying local immune responses to allergens.
Article
Nutrition & Dietetics
Severina Terlouw, Frank E. van Boven, Monika Borsboom-van Zonneveld, Catharina de Graaf-in 't Veld, Marloes E. van Splunter, Paul L. A. van Daele, Maurits S. van Maaren, Marco W. J. Schreurs, Nicolette W. de Jong
Summary: The study compared the SPT results of homemade food allergen extracts with commercially available extracts, finding that homemade hazelnut and walnut extracts can be good alternatives in the absence of commercial extracts. The agreement between SPT results and food allergen-specific symptoms were comparable for homemade and commercial extracts, except for peach.
Article
Biochemistry & Molecular Biology
Daria Trifonova, Mirela Curin, Ksenja Riabova, Antonina Karsonova, Walter Keller, Hans Groenlund, Ulrika Kaeck, Jon R. Konradsen, Marianne van Hage, Alexander Karaulov, Rudolf Valenta, Kurt A. Jellinger
Summary: More than 10% of the world's population suffers from an IgE-mediated allergy to cats, which mainly manifests as respiratory symptoms. Several cat allergens have been identified, and Fel d 1, Fel d 4, and Fel d 7 show high allergenic activity in patients with respiratory allergies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Kavita Reginald, Fook Tim Chew
Summary: This review evaluates the current modes of allergen-specific immunotherapy for cockroach allergens in terms of clinical outcomes and explores future trends in research and development for a more targeted approach to cockroach immunotherapy with better efficacy and fewer adverse effects.
MOLECULAR IMMUNOLOGY
(2023)
Article
Allergy
Alina Gherasim, Frank Dietsch, Marine Beck, Nathalie Domis, Frederic de Blay
Summary: This study aimed to investigate birch induced allergic rhinitis under 3 different conditions and found that the outcomes in environmental exposure chambers (EECs) were similar to those obtained with nasal allergen challenge (NAC) and natural exposure, suggesting the usefulness of EEC in allergic rhinitis studies.
WORLD ALLERGY ORGANIZATION JOURNAL
(2023)
Review
Immunology
Nishelle D'souza, Milena Weber, Eszter Sarzsinszky, Susanne Vrtala, Mirela Curin, Mirjam Schaar, Victoria Garib, Margarete Focke-Tejkl, Yanqiu Li, Richard Jones, Hao Chen, Rudolf Valenta, Baoqing Sun
Summary: Approximately 30% of the global population suffers from IgE-mediated allergy, with China having the largest population and over 400 million allergic patients. Allergy prevention and treatment strategies include allergen avoidance, vaccination, and tolerance induction, requiring a detailed understanding of relevant allergen molecules affecting specific populations.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Allergy
Sarah A. Lyons, Paco M. J. Welsing, Mariam Hakobyan, Hannah M. Kansen, Edward F. Knol, Henny G. Otten, Ronald van Ree, Andre C. Knulst, Thuy-My Le
Summary: The study found that IgE testing for hazelnut extract and components is not accurate in predicting hazelnut allergy in adults. Therefore, challenge testing is still necessary to accurately discriminate between presence and absence of hazelnut allergy in adults from a birch-endemic country.
Article
Immunology
Yasmeen S. El Ansari, Cynthia Kanagaratham, Oliver T. Burton, Jenna V. Santos, Brianna-Marie A. Hollister, Owen L. Lewis, Harald Renz, Hans C. Oettgen
Summary: Mast cells and basophils play important roles in IgE-mediated hypersensitivity reactions. IgG and IgA antibodies can regulate the activation of these cells by activating or inhibiting receptors. This study found that IgA antibodies can bind to mast cells and basophils, and inhibit their activation to maintain immune homeostasis at mucosal sites.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Almudena Testera-Montes, Maria Salas, Francisca Palomares, Adriana Ariza, Maria J. Torres, Carmen Rondon, Ibon Eguiluz-Gracia
Summary: Local respiratory allergy (LRA) is characterized by negative atopy tests, clinical history of airway allergy, and positive response to allergen challenge. LRA includes conditions like local allergic rhinitis (LAR) and local allergic asthma in non-atopic patients, and dual allergic rhinitis in atopic individuals. LRA is mediated through mucosal synthesis of allergen-specific IgE and can be treated effectively with allergen immunotherapy (AIT).
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Allergy
Jonathan Corren, David Larson, Matthew C. Altman, R. Max Segnitz, Pedro C. Avila, Paul A. Greenberger, Fuad Baroody, Mark H. Moss, Harold Nelson, Allison J. Burbank, Michelle L. Hernandez, David Peden, Sarbjit Saini, Stephen Tilles, Iftikhar Hussain, Don Whitehouse, Tielin Qin, Miguel Villarreal, Michelle Sever, Lisa M. Wheatley, Gerald T. Nepom, Srinath Sanda
Summary: This study evaluated whether tezepelumab, a human monoclonal anti-TSLP antibody, improved the efficacy of subcutaneous allergen immunotherapy (SCIT) and promoted tolerance in patients with allergic rhinitis. The results showed that inhibition of TSLP augmented the efficacy of SCIT during therapy and may promote tolerance after a 1-year course of treatment.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Claudia Petrarca, Davide Viola
Summary: This study conducted a post hoc analysis to investigate the effect of endogenous vitamin D on the immunological mechanism underlying effective mite allergoid immunotherapy (AIT). The results showed that AIT is able to reshape the immune response against allergens and that vitamin D plays a role in this process. Patients with lower endogenous vitamin D levels had worse symptoms and higher medication use, while those concurrently taking VD3 as a supplement showed the best treatment outcomes. This suggests that vitamin D levels affect allergy severity and the effectiveness of allergen immunotherapy.
Article
Immunology
I-Hui Lin, Ming-Chin Tsai, Jun-Peng Chen, Lin-Shien Fu
Summary: The study found that for two thirds of atopic children, a specific allergen could be identified during follow-up tests. Specific allergens could be identified through MAST tests and further assist in treatment options.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Allergy
Rebecca N. Bauer, Yanqing Xie, Suzanne Beaudin, Lesley Wiltshire, Jennifer Wattie, Caroline Munoz, Nadia Alsaji, John Paul Oliveria, Xiaotian Ju, Jonathan Maclean, Doron D. Sommer, Paul K. Keith, Imran Satia, Ruth P. Cusack, Paul M. O'Byrne, Gizette Sperinde, Martha Hokom, Olga Li, Prajna Banerjee, Chen Chen, Tracy Staton, Roma Sehmi, Gail M. Gauvreau
Summary: The nasal allergen challenge (NAC) is a suitable early phase experimental model for drug development targeting allergic rhinitis and asthma. This study assessed the reproducibility of NAC and the effects of intranasal corticosteroids (INCS) on symptoms, physiology, and inflammatory mediators. The results showed that NAC induced significant changes in nasal symptoms and biomarkers, and INCS treatment inhibited these changes to some extent.
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Article
Allergy
Gyaviira Nkurunungi, Jacent Nassuuna, Harriet Mpairwe, Joyce Kabagenyi, Margaret Nampijja, Richard E. Sanya, Emily L. Webb, Alison M. Elliott
Summary: Our study suggests that the balance between IgG4 and IgE, as well as the balance between total IgE and allergen-specific IgE, are more important than the absolute levels of total, helminth- or allergen-specific antibodies in inhibiting allergies in tropical regions. High IgG4/IgE ratios were associated with beneficial responses in allergen immunotherapy, while helminth infections were positively correlated with total IgE and allergen-specific IgE responses. Additionally, asthmatic schoolchildren had higher levels of total and allergen-specific IgE, but lower ratios of allergen-specific IgG4/IgE and total IgE/allergen-specific IgE compared to non-asthmatic controls.
CLINICAL AND EXPERIMENTAL ALLERGY
(2021)