Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 356, Issue 8, Pages 1789-1794Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201400103
Keywords
biocatalysis; laccase; oxidation; oxidoreductases; quinazolinones
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Funding
- Biotechnology Research Center, Tehran University of Medical Sciences, Tehran, Iran [92-02-90-23628]
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This paper describes the synthesis of quinazolinones via a tandem reaction using the laccase-mediator system under mild conditions. The procedure involved the laccase-catalyzed oxidation of alcohols to the corresponding aldehydes, followed by cyclocondensation with isatoic anhydride and a number of amines to afford 2,3-dihydroquinazolin-4(1H)-ones, which were further oxidized to quinazolinones in useful yields. The use of an enzyme as the catalyst, O2 as an environmentally friendly oxidant, and a citrate buffer as the green solvent represents a novel and efficient approach for the one-pot synthesis of quinazolinones.
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