Palladium-Catalyzed Desulfitative Direct C-H Arylation of Electron-Deficient Polyfluoroarenes with Sodium Arenesulfinates

The palladium-catalyzed direct arylation of electron-deficient polyfluorobenzenes was developed in the presence of silver carbonate and trisodium phosphate. This protocol allowed use of both electron-deficient and electron-rich aromatic sulfinic acid sodium salts as arylating reagents for the direct arylation of a variety of polyfluoroarenes to produce fluorobiaryls in good to excellent yields, providing a complement to the existing methods for the direct arylation of polyfluoroarenes.