Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 355, Issue 4, Pages 659-666Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201200853
Keywords
(E)-1-alkenylphosphine oxides; bisphosphine oxides; 1; 1-dibromo-1-alkenes; DFT calculations; nickel(II)-magnesium catalysis
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Funding
- Chinese National Natural Science Foundation [21202135, 21075103, 21232005]
- National Basic Research Program of China [2012CB821600]
- [TJAB-2009-023]
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A novel nickel(II)-magnesium-mediated cross-coupling of diphenylphosphine oxide with a variety of 1,1-dibromo-1-alkenes has been developed, which provides a powerful and general methodology for the stereoselective synthesis of various (E)-1-alkenylphosphine oxides or bisphosphine oxides, with operational simplicity of the procedure, good to high yields and broad substrate applicability. Mechanistic studies reveal that the reaction might involve a Hirao reduction, cross-coupling and Michael addition.
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