Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 355, Issue 8, Pages 1455-1463Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201201104
Keywords
asymmetric hydrogenation; BIPI ligands; naphthalenes; peri position; unfunctionalized olefins
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The modular nature of the BIPI ligands allows for systematic optimization of each ligand region. The development of ligands optimized for asymmetric hydrogenation of the challenging unfunctionalized olefin substrate class is described. The naphthyl peri position, C-8, has been identified as a critical stereocontrol element in the design of these ligands. Highly enantioselective ligands suitable for hydrogenation of tri- and tetrasubstituted olefins are detailed.
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