Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 353, Issue 4, Pages 538-544Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201000800
Keywords
carboxylate directed aminations; copper; 2,4-dibromobenzoic acid; palladium; selective aromatic aminations
Categories
Ask authors/readers for more resources
The carboxylate anion has been used as a directing group in the aromatic amination of electronically equivalent aryl bromides to afford selective ortho-substituted derivatives (>99:1 selectivity; 60-80% yield) in the case of copper(I) catalysis. The solvent, base and equivalents of base were important factors in the success of this reaction. Complementary selectivity was achieved with palladium catalysis where the para-substituted derivatives were produced selectively (>99% selectivity, 70-80% yield).
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available