☆ 4.7 Article

Phosphoric Acid-Catalyzed Enantioselective Transfer Hydrogenation of N-Aryl-ortho-Hydroxybenzophenone Ketimines

ADVANCED SYNTHESIS & CATALYSIS (2011)

Journal

ADVANCED SYNTHESIS & CATALYSIS

Volume 353, Issue 2-3, Pages 257-262

Publisher

WILEY-V C H VERLAG GMBH

DOI: 10.1002/adsc.201000754

Keywords

diarylmethylamines; Hantzsch esters; ortho-hydroxybenzophenone ketimine; organocatalysis; phosphoric acids; transfer hydrogenation

Categories

Chemistry, Applied Chemistry, Organic

Funding

CNRS
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Abstract

The first enantioselective chiral phosphoric acid-catalyzed transfer hydrogenation of N-aryl-ortho-hydroxybenzophenone ketimines using a Hantzsch ester as hydrogen source was developed to afford, after removal of the N-aryl group, the corresponding chiral diarylmethylamines in high yields and enantioselectivities.

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