Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 353, Issue 2-3, Pages 495-500Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201000577
Keywords
alcohols; asymmetric catalysis; hydrogenation; N ligands; ruthenium
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Funding
- Chinese Academy of Sciences [O7210122R0]
- National Natural Science Foundation of China [20620140429]
- Enantiotech Corp., Ltd.
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Readily available and modular hybrid amine/benzimidazole-based 1H-benzimidazole-2-methanamine (BIMA) ligands in combination with 2,3-O-isopropylidene-2,3-dihydroxy-1,4-bis(diphenylphosphino) butane (DIOP) afford efficient catalytic systems for the ruthenium(II)-catalyzed asymmetric hydrogenation (AH) of a number of aryl ketones. The AH proceeds smoothly with substrate-to-catalyst (S/C) molar ratios of up to 100,000 (TOF of 6500 h(-1), 8 atm) giving chiral alcohols in up to 99% ee.
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