Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 352, Issue 6, Pages 1047-1054Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.200900871
Keywords
aldehydes; asymmetric carbonylation; hydroaminomethylation; hydroformylation; racemization
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Funding
- EPSRC-Chemistry Innovation Knowledge Transfer Network
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Dimethylacrylamide can be hydroformylated with very high chemo- and regioselectivity. Asymmetric hydroformylation of this substrate is possible, provided steps are taken to minimise racemisation of the aldehyde products, and this work demonstrates the effect of various conditions and variables on racemisation. Using the Landis diazaphospholane ligands up to 68% ee can be realised under very mild conditions. Other dialkylacrylamides were also hydroformylated under mild conditions giving similar or better enantioselectivities, including the Weinreb amide of acrylic acid (71% ee), and the asymmetric hydroformylation of diethylacrylamide producing the chiral aldehyde with up to 82% ee.
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