Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 352, Issue 13, Pages 2227-2232Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201000178
Keywords
biomimetic process; Hantzsch esters; nucleotides; reductive amination
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Funding
- CSIR New Delhi
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We have successfully developed a single nucleotide (adenosine 5'-diphosphate)-catalyzed enantioselective direct reductive amination of aldehydes and ketones using a Hantzsch ester as reducing agent. The process is a simple, efficient and a real mimic of the NADH reduction approach for the synthesis of structurally diverse amines. This reaction is the first report demonstrating the ability of a single nucleotide as catalyst and one of the most genuine biomimetic reactions of organic chemistry.
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