Alternation of Chemoselective Control in Stille-Heck and Heck-Stille Reaction Sequences

Sequential and one-pot Stille-Heck and Heck-Stille reaction processes have been invoked to give divergent access to polycyclic ring systems. Both reaction conditions and substrate structure are important in determining the nature of the reaction products formed. The Heck-Stille reactions have involved a reversal of the usual Heck regioselectivity and both cine- and ipso-substitutions have been observed in the Stille reaction.