Journal
INTERNAL MEDICINE
Volume 54, Issue 18, Pages 2377-2382Publisher
JAPAN SOC INTERNAL MEDICINE
DOI: 10.2169/internalmedicine.54.4623
Keywords
IgA nephropathy; aspirin; eicosapentaenoic acid; steroids
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Funding
- Grants-in-Aid for Scientific Research [15K09247] Funding Source: KAKEN
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Immunoglobulin (Ig) A nephropathy is a prevalent form of primary glomerulonephritis, which leads to end-stage renal failure in a significant proportion of patients. Immunotherapy, including steroid use, is widely used to induce disease remission; however, it can cause serious side effects. We herein report 3 cases of progressive IgA nephropathy and their successful treatment with a combination of aspirin and eicosapentaenoic acid (EPA) without the use of steroids. The precise mechanism responsible for the combination therapy is still unknown; however, aspirin may potentiate the production of anti-inflammatory lipid mediators derived from EPA. Further clinical trials are required to substantiate this treatment regimen.
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