Article
Polymer Science
Julia Kredel, Deborah Schmitt, Jan-Lukas Schaefer, Markus Biesalski, Markus Gallei
Summary: The study explores different strategies for a durable resistant cross-linking of a novel fluoropolymer on the surface of fibers. Coating surfaces with fluoropolymers can achieve oil and chemical repellent textiles. The use of degradable fluorinated side-chain monomers in polymer synthesis ensures durability during textile washing processes.
Article
Biochemistry & Molecular Biology
Emily Diep, Jessica D. Schiffman
Summary: Water-stable, calcium-crosslinked alginate nanofibers were developed using different post-electrospinning cross-linking approaches. The cross-linked fibers showed similar morphology to ethanol-based fibers and exhibited smaller diameter. The stability tests demonstrated the potential of these cross-linked nanofibers for pH-controlled release applications.
Article
Chemistry, Physical
Yungang Bai, Fan Zhang, Kun Xu, Xinyue Wang, Chao Wang, Hao Zhang, Ying Tan, Pixin Wang
Summary: This study effectively controlled the surface wettability of polymer microspheres using the Pickering emulsion template method, achieving efficient oil-water separation with a valuable strategy for designing materials with special wettability.
APPLIED SURFACE SCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Jueun Kim, Yeong-Jin Choi, Honghyun Park, Hui-suk Yun
Summary: Novel alginate-hydroxyapatite hybrid microspheres were developed for simultaneous delivery of drugs and cells for osteoporotic bone tissue regeneration. The microspheres enhanced osteogenesis and carried and delivered quercetin, a phytoestrogen, through sustained release. The presence of hydroxyapatite boosted the osteogenic differentiation behavior of cells encapsulated in the hybrid microspheres. These multi-biofunctional microspheres have great potential for the regeneration of osteoporotic bone tissue.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Kar Yin Goh, Yern Chee Ching, Mei Han Ng, Cheng Hock Chuah, Sabariah Binti Julai Julaihi
Summary: In this study, palm-based vitamin E-loaded emulsions were immobilized within microbeads made of cellulose and alginate. The microbeads showed good physical properties and controlled release capabilities.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Concetta Di Natale, Elena Lagreca, Valeria Panzetta, Marianna Gallo, Francesca Passannanti, Michele Vitale, Sabato Fusco, Raffaele Vecchione, Roberto Nigro, Paolo Netti
Summary: The intestinal microbiota, composed of various bacterial species and strains, plays a crucial role in immune system development and function. Probiotics, through modulation of the microbiota, offer potential in the pharmaceutical and healthcare market. Encapsulation strategies have shown promise in protecting probiotic viability, with a need for optimization to ensure stability.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Tamara Athamneh, Adil Amin, Edit Benke, Rita Ambrus, Pavel Gurikov, Irina Smirnova, Claudia S. Leopold
Summary: The study utilized aerogel technology to prepare pulmonary drug carriers with high porosity, low density, and large surface area suitable for pulmonary drug delivery, demonstrating a non-Fickian drug release mechanism.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Xiao-Wei Chen, Qi-Hua Hu, Xiao-Xiao Li, Chuan-Guo Ma
Summary: This study investigated the effects of different emulsion types, oil compositions, and oil fractions on the structure and lipid oxidation in emulgel systems. It was found that emulgels were more susceptible to oxidation compared to soybean oil, with water-in-oil emulgels showing higher oxidation resistance than oil-in-water emulgels. Additionally, the degree of unsaturation in the oil composition and oil fraction had significant impacts on lipid oxidation in the biphasic emulgel systems.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Chemistry, Multidisciplinary
Saahil Sheth, Samuel Stealey, Nicole Y. Morgan, Silviya P. Zustiak
Summary: Hydrogel microspheres are widely used in biomedical applications, but the challenge lies in mixing precursor solutions for timed gelation systems. Through the design and evaluation of mixing devices, the serpentine geometry with a pillar array was found to be the most effective in fully mixing precursor solutions and enabling the fabrication of monodisperse microspheres.
Article
Nanoscience & Nanotechnology
Matthew A. Campea, Andrew Lofts, Fei Xu, Mina Yeganeh, Meghan Kostashuk, Todd Hoare
Summary: In this study, a nanogel-based nanoassembly was developed by encapsulating ultra-small starch nanoparticles within disulfide-crosslinked chondroitin sulfate-based nanogels to address the challenge of different sizes needed for drug delivery pathway. The chondroitin sulfate-based nanogel can degrade in the tumor microenvironment to release doxorubicin-loaded starch nanoparticles, thereby improving intratumoral penetration. In vitro experiments demonstrated efficient penetration of CT26 colon carcinoma spheroids by the nanoassembly, resulting in significantly higher DOX-derived fluorescence compared to free DOX. In vivo experiments showed that doxorubicin-loaded nanoassemblies reduced tumor sizes by 6 times compared to saline controls and 2 times compared to free DOX after 21 days.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Applied
Mustapha El Hariri El Nokab, Alessia Lasorsa, Khaled O. Sebakhy, Francesco Picchioni, Patrick C. A. van der Wel
Summary: Alginate hydrogels are versatile materials with diverse applications in biomedicine and food industry. The formation of hydrogel involves cross-linking with calcium ions and hydration of alginate groups. Solid-state NMR spectroscopy is used to detect and study water molecules in re-hydrated alginate hydrogels, revealing the different water phases and the effects of calcium cross-linking on water-filled macropores.
FOOD HYDROCOLLOIDS
(2022)
Article
Pharmacology & Pharmacy
O. Sreekanth Reddy, M. C. S. Subha, T. Jithendra, C. Madhavi, K. Chowdoji Rao
Summary: The aim of this study was to fabricate dual cross linked sodium alginate/montmorillonite microbeads as a potential drug carrier for extended release of curcumin. Characterization of the microbeads was done using FTIR, DSC, TGA, X-RD, and SEM. The swelling and in vitro release studies of the microbeads were influenced by the pH of test media, indicating their potential for intestinal drug delivery.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2021)
Review
Chemistry, Multidisciplinary
Simona Summonte, Giuseppe Francesco Racaniello, Angela Lopedota, Nunzio Denora, Andreas Bernkop-Schnuerch
Summary: Thiomers, such as thiolated hyaluronic acid and chitosan, are widely studied for their high reactivity in hydrogel synthesis. They exhibit in situ gelling properties and can undergo various click reactions, making them versatile materials for tissue engineering, regenerative medicine, and drug delivery.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Multidisciplinary Sciences
Alexandra Mun, Haneen Simaan Yameen, Giora Edelbaum, Dror Seliktar
Summary: This study aimed to create a novel agricultural controlled release (CR) device using alginate hydrogel beads embedded with drug-bearing Polycaprolactone (PCL) microspheres, demonstrating the potential for sustained growth inhibition through the controlled release formulation of Paclobutrazol (PBZ) in oatmeal plants.
SCIENTIFIC REPORTS
(2021)
Article
Polymer Science
Trevor Gilbert, Matthew A. Campea, Nahieli Preciado Rivera, Michael Majcher, Richard Alsop, Mouhanad Babi, Thomas Kalab, Jose Moran-Mirabal, Maikel Rheinstadter, Todd Hoare
Summary: In this study, injectable PNIPAM/PVP interpenetrating polymer networks were fabricated and characterized. The results show that the internal structure of the injectable IPNs can be controlled by adjusting the PVP molecular weight and degree of thiolation. The PNIPAM gelation drives the formation of domains, with PNIPAM mainly located in the PVP-rich domains and PVP entrapped in the PNIPAM-rich domain. Additionally, the structural reconfiguration of the IPNs can be achieved by heating above the volume phase transition temperature of the PNIPAM phase, which is influenced by the molecular weight and thiolation degree of the PVP precursor polymers.
Article
Engineering, Chemical
Yongxiang Wu, Nguyen Thi Hong Nhung, Deqian Zeng, Nengneng Luo, Akira Otsuki, Gjergj Dodbiba, Toyohisa Fujita
Summary: This study proposed a novel method for synthesizing flower-like vaterite calcium carbonate using nanobubble-containing ethanol and water mixed solution as the solvent and discussed the formation mechanism of vaterite with different shapes. The synthesized vaterite has significant practical interest in the integrated treatment of wastewater contaminated by heavy metals with effective Cd(II) removal, providing a promising field for studying heavy metal and pollutant adsorption in the liquid phase.
ADVANCED POWDER TECHNOLOGY
(2024)
Article
Engineering, Chemical
Jian Gong, Lipo Cheng, Ming Liu, Jie Jiang, Xiaoduo Ou
Summary: This study investigates the effects of particle shape on the collapse of granular columns using the discrete element method. The results show that particle shape has a significant impact on deposition morphology, energy evolution, and mechanical coordination number. Sphericity and angularity are identified as the most important macroscale factors, while roughness has a weaker microscale influence.
ADVANCED POWDER TECHNOLOGY
(2024)
