Article
Chemistry, Multidisciplinary
Yen-Lan Chang, Pei-Bang Liao, Ping-Han Wu, Wei-Jen Chang, Sheng-Yang Lee, Haw-Ming Huang
Summary: The low-molecular-weight hyaluronic acid-conjugated superparamagnetic iron oxide nanoparticles synthesized in this study exhibited selective cytotoxicity toward cancer cells and had no cytotoxic effects on normal fibroblast cells. These nanoparticles have the potential to be used as both a candidate for magnetic resonance imaging applications and an injectable anticancer agent.
Article
Nanoscience & Nanotechnology
Yulian Chen, Qian Zhang, Xuan Qin, Jin Li, Yantao Zhao, Yang Xia
Summary: This study demonstrates that polyglucose sorbitol carboxymethyl ether (PSC) coated superparamagnetic iron oxide nanoparticles (SPIONs) can protect human gingival fibroblasts (hGFs) against invasion and inflammatory stimulation by Porphyromonas gingivalis (P. gingivalis).
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Chichong Lu, Xue Xu, Tingting Zhang, Zhijie Wang, Yuyun Chai
Summary: This study presents a simple and efficient method to engineer manganese-doped iron oxide nanoclusters (MnIO NCs) with excellent water-solubility, colloidal stability, biocompatibility, and superparamagnetic properties. MnIO NCs show great potential in T-1-T-2 dual-mode magnetic resonance imaging for deep tissue.
ACS APPLIED NANO MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Pierre-Olivier Champagne, Nathalie T. Sanon, Lionel Carmant, Dang Khoa Nguyen, Sylvain Deschenes, Philippe Pouliot, Alain Bouthillier, Mohamad Sawan
Summary: In this study, it was found that the aggregation of SPIONs near active brain tissue was proportional to the level of neuronal activity. The findings suggest that the MRI signal change induced by SPIONs aggregation could serve as a powerful tool for detecting brain electrical activity.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Lorenzo Cursi, Silvia Vercellino, Mura M. McCafferty, Emily Sheridan, Vanya Petseva, Laurent Adumeau, Kenneth A. Dawson
Summary: Magnetic nanoparticles are valuable tools for studying complex intracellular bio-nano interactions. By synthesizing biocompatible multifunctional nanoparticles with fluorescent properties, intracellular tracking of nanoparticles can be achieved, providing a promising approach for studying bio-nano interactions.
Article
Chemistry, Physical
Mehri Karimi Jabali, Ali Reza Allafchian, Seyed Amir Hossein Jalali, Hamideh Shakeripour, Rezvan Mohammadinezhad, Fahime Rahmani
Summary: The study introduces the use of ascorbic acid-modified chitosan as a pDNA nanocarrier, demonstrating promising pDNA release in intestinal fluids and potential biocompatibility with cell lines Vero and EPC. Chitosan effectively shields pDNA in gastric environments and allows for release in alkaline intestinal tissues, presenting a novel approach for gene delivery through oral administration.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Materials Science, Multidisciplinary
Najma Annuria Fithri, Yuao Wu, Gary Cowin, Fahima Akther, Huong D. N. Tran, Brian Tse, Nicholas Westra van Holthe, Shehzahdi S. Moonshi, Karlheinz Peter, Xiaowei Wang, Nghia P. Truong, Hang Thu Ta
Summary: In this study, activated platelet targeted gold-iron oxide nanoparticles were developed for the diagnosis and treatment of thrombosis related diseases. The nanoparticles enabled triple imaging modalities of magnetic resonance imaging, photoacoustic imaging, and fluorescence imaging, and also facilitated photothermal thrombolysis. The in vivo observation showed enhanced contrast and thrombus reduction in the targeted group compared to the non-targeted group.
APPLIED MATERIALS TODAY
(2023)
Article
Chemistry, Applied
Aleksandrina M. Sulman, Angela K. Haskell, Boris B. Tikhonov, Olga V. Grebennikova, Aleksandr I. Sidorov, Lyudmila M. Bronstein, Valentina G. Matveeva
Summary: In this study, the influence of pore size on the loading of an immobilized enzyme (glucose oxidase) and the activity and reusability of the biocatalyst in D-glucose oxidation was investigated. The study demonstrated that larger pores allow for higher enzyme loading capacity, improved activity, and enhanced stability in repeated use. This research clearly shows the advantages of using supports with pores larger than the size of the enzyme in biocatalyst synthesis.
MICROPOROUS AND MESOPOROUS MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Sharafaldin Al-Musawi, Salim Albukhaty, Hassan Al-Karagoly, Faizah Almalki
Summary: A dual-targeting nanomedicine composed of pH-sensitive superparamagnetic iron oxide core-gold shell SPION@Au, chitosan (CS), and folate (FA) was developed for doxorubicin (DOX) antitumor medication. The nanocomposite exhibited elevated drug loading behavior and sustained drug release capacity, with long-term anti-cancer efficacy shown in SkBr3 cell lines. In vivo results demonstrated significant tumor size reduction in treated mice, indicating the potential of this formulation for clinical breast cancer treatment.
Article
Chemistry, Multidisciplinary
Kyle M. Kirkpatrick, Benjamin H. Zhou, Philip C. Bunting, Jeffrey D. Rinehart
Summary: Magnetization is a measurable property of materials that provides information about their electronic structure, phase purity, and impurities. Superparamagnetism, a size-dependent property of magnetic materials, has been underexplored in the field of quantum materials. In this study, a statistical model is used to analyze a dataset of variable-size superparamagnetic Fe3O4 particles. The results show that parameters of the intrinsic probability distribution, such as the maximum susceptibility, are more suitable for describing the superparamagnetic behavior compared to standard measures like saturation magnetization. This analysis has potential applications in synthesis diagnostics and prediction of new properties and functionality.
Article
Chemistry, Physical
Zeynep Dasdelen, Ayca Atilir Ozcan, Ali Ozcan
Summary: In this study, fumed silica, reduced graphene oxide, and their hybrid were tested as support materials for Au nanoparticles to prepare anode catalysts for sorbitol fuel cells. Among the different supports, Au@FS-rGO catalyst showed the highest current density for sorbitol oxidation, indicating a synergistic effect between FS and rGO.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2021)
Article
Chemistry, Multidisciplinary
Xinyi Zhao, Gwendoline Smith, Bilal Javed, Garret Dee, Yurii K. Gun'ko, James Curtin, Hugh J. Byrne, Christine O'Connor, Furong Tian
Summary: The study developed two methods using nanoparticles and antibodies for detecting Salmonella. The ICGNP method showed higher sensitivity and specificity, providing effective detection of Salmonella.
Review
Biochemistry & Molecular Biology
Mohammed Ali Dheyab, Azlan Abdul Aziz, Mahmood S. Jameel
Summary: Sonochemistry involves using ultrasound to enhance chemical reactions, such as the formation of free radicals. Recent studies have focused on synthesizing nanomaterials using sonochemistry, with a particular emphasis on iron oxide nanoparticles, gold nanoparticles, and iron oxide-coated gold nanoparticles. These materials are widely studied for various applications and the review aims to provide a comprehensive overview of the available literature knowledge.
Article
Pharmacology & Pharmacy
Elena alvarez, Manuel Estevez, Alvaro Gallo-Cordova, Blanca Gonzalez, Rafael R. Castillo, Maria del Puerto Morales, Montserrat Colilla, Isabel Izquierdo-Barba, Maria Vallet-Regi
Summary: This study combines magnetic hyperthermia with controlled antibiotic delivery from a unique magnetic-responsive nanocarrier to effectively manage biofilm-associated infections. The results show a significant decrease in viable bacteria count when E. coli biofilms are exposed to the nanosystem and an alternating magnetic field.
Article
Nanoscience & Nanotechnology
Gilbert Aaron Lee, Wan-Li Lin, Duen-Pang Kuo, Yi-Tien Li, Yu-Wei Chang, Yung-Chie Chen, Shiu-Wen Huang, Justin Bo-Kai Hsu, Cheng-Yu Chen
Summary: Lipid-coated SPIO nanoparticles conjugated with PD-L1 antibodies can specifically target PD-L1 expression in glioblastoma, including temozolomide-resistant cases, as demonstrated in this study through characterizations such as dynamic light scattering and in vivo T2* map MRI analysis. This approach shows promise for early diagnosis and predicting responses to targeted PD-L1 immunotherapy in glioblastoma patients.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Polymer Science
Kazuo Tanaka, Yoshiki Chujo
Summary: This review introduces a new concept of developing stimuli-responsive luminochromic materials based on frustrated element-blocks. The stimuli-responsive properties and luminescent behaviors of frustrated boron clusters are described. Methods for obtaining materials with unique chromic behaviors, such as designing fused complexes and generating frustrated state by polymerization, are also discussed.
Article
Chemistry, Multidisciplinary
Junki Ochi, Kazuo Tanaka, Yoshiki Chujo
Summary: The unique solid-state excimer emission of three types of acridine-tethered o-carboranes with variable degrees of methylation was reported. The emitted light colors were drastically changed by the steric effect of the methyl groups, with a strong correlation found between the pi-overlapping and excimer character. Variable-temperature PL measurements revealed that these PL species should be in thermal equilibrium at room temperature.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Kazuhiro Yuhara, Kazuo Tanaka
Summary: This study reports the luminochromic behaviors of o-carborane-modified anthracene derivatives regarding mechanochromic luminescence (MCL). Crystal polymorphs of bis-o-carborane-substituted anthracene showed dual-emission properties in the solid state, characterized by excimer and charge transfer (CT) emission bands. Compound 1a exhibited bathochromic MCL due to a transition from dual emission to CT emission, while compound 2 displayed hypsochromic MCL resulting from a transition from CT to excimer emission. Additionally, ground 1a showed self-recovery of its luminescent color when left at room temperature.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Materials Science, Multidisciplinary
Takumi Yanagihara, Kazuo Tanaka
Summary: This study presents the unique luminescent properties of pyrene-substituted nido-carborate anion (PYnCA) with two counter cations, NBu4+ and PPh4+. It is found that PYnCA exhibits twisted intramolecular charge transfer (TICT) emission by changing the dihedral angle between pyrene and the C-cage-C-cage bond in the carborane unit. The research also demonstrates the modulation of luminescent species by counter cations in both solution and solid states, showing potential for stimuli-responsive materials.
ADVANCED OPTICAL MATERIALS
(2023)
Article
Chemistry, Organic
Hiroyuki Watanabe, Yoshinori Ito, Kazuo Tanaka, Yoshiki Chujo
Summary: The development of 1,3,4,6,8,9b-hexaazaphenalene (6AP) derivatives with excellent NIR light absorption properties and deep LUMO levels is illustrated. The electron-withdrawing ability of the 8-nitrogen atom in the 6AP scaffold was enhanced by introducing a B-N dative bond. The formation of a boron-nitrogen Lewis acid-base pair strengthened the electron-withdrawing ability and induced the low-lying LUMO levels.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Haoran Wang, Qiyao Li, Parvej Alam, Haotian Bai, Vandana Bhalla, Martin R. Bryce, Mingyue Cao, Chao Chen, Sijie Chen, Xirui Chen, Yuncong Chen, Zhijun Chen, Dongfeng Dang, Dan Ding, Siyang Ding, Yanhong Duo, Meng Gao, Wei He, Xuewen He, Xuechuan Hong, Yuning Hong, Jing-Jing Hu, Rong Hu, Xiaolin Huang, Tony D. James, Xingyu Jiang, Gen-ichi Konishi, Ryan T. K. Kwok, Jacky W. Y. Lam, Chunbin Li, Haidong Li, Kai Li, Nan Li, Wei-Jian Li, Ying Li, Xing-Jie Liang, Yongye Liang, Bin Liu, Guozhen Liu, Xingang Liu, Xiaoding Lou, Xin-Yue Lou, Liang Luo, Paul R. McGonigal, Zong-Wan Mao, Guangle Niu, Tze Cin Owyong, Andrea Pucci, Jun Qian, Anjun Qin, Zijie Qiu, Andrey L. Rogach, Bo Situ, Kazuo Tanaka, Youhong Tang, Bingnan Wang, Dong Wang, Jianguo Wang, Wei Wang, Wen-Xiong Wang, Wen-Jin Wang, Xinyuan Wang, Yi-Feng Wang, Shuizhu Wu, Yifan Wu, Yonghua Xiong, Ruohan Xu, Chenxu Yan, Saisai Yan, Hai-Bo Yang, Lin-Lin Yang, Mingwang Yang, Ying-Wei Yang, Juyoung Yoon, Shuang-Quan Zang, Jiangjiang Zhang, Pengfei Zhang, Tianfu Zhang, Xin Zhang, Xin Zhang, Na Zhao, Zheng Zhao, Jie Zheng, Lei Zheng, Zheng Zheng, Ming-Qiang Zhu, Wei-Hong Zhu, Hang Zou, Ben Zhong Tang
Summary: This review provides a comprehensive summary of the applications of aggregation-induced emission (AIE) luminogens in biological imaging, dynamic physiological processes, disease diagnosis and treatment, and specific analyte detection and monitoring. The review also discusses critical issues and future directions, aiming to promote the development of AIE in the fields of life and health.
Article
Chemistry, Multidisciplinary
Masayuki Gon, Misao Yaegash, Kazuo Tanaka
Summary: This article presents a study on near-infrared luminescent materials. By introducing electron-donating groups, the luminescence properties of these materials were enhanced, and factors affecting their luminescent behavior were identified. These findings are significant for the development of tunable near-infrared luminescent materials.
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
(2023)
Article
Chemistry, Multidisciplinary
Hiromasa Takahashi, Hiroyuki Watanabe, Shunichiro Ito, Kazuo Tanaka, Yoshiki Chujo
Summary: We synthesized new binuclear boron complexes based on pyrazine with ortho and para substitution patterns. The para-linked complexes showed a narrow energy gap between highest occupied and lowest unoccupied molecular orbitals, resulting in far-red to near-infrared emission properties. Meanwhile, the ortho-substituted complex exhibited orange emission. The theoretical study suggested that the para-substitution did not significantly perturb the characteristic HOMO distribution originating from pyrazine, unlike the ortho-substituted one.
CHEMISTRY-AN ASIAN JOURNAL
(2023)
Article
Polymer Science
Chisa Takahara, Masashi Nakamura, Yuto Aoyama, Takumi Yanagihara, Shunichiro Ito, Kazuo Tanaka, Hiroaki Imoto, Kensuke Naka
Summary: Arsenic-containing conjugated polymers, with dithieno[3,2-b:2',3'-d]arsole as a typical monomer unit, have gained significant attention recently. However, the traditional polymer design for improved solubility often involves introducing long alkyl chains, which may lead to steric hindrance and distort the planarity of the polymer chain. To overcome this, a novel monomer with an alkoxyphenyl group substituted on the arsenic atom was developed. These polymers, using benzothiadiazole and benzoxadiazole monomers, exhibited high planarity and solubility, as well as near-infrared emissions.
Article
Polymer Science
Kazumasa Suenaga, Aoi Watanabe, Kazuo Tanaka, Yoshiki Chujo
Summary: The logical design and synthesis of a blue-luminescent film based on a conjugated polymer is demonstrated by utilizing aza-substituted FBKI. The aza-substituted FBKIs exhibit solid-state luminescent properties and wider energy gaps compared to the corresponding FBKIs. A conjugated homopolymer including azaFBKI as a repeating unit is successfully designed and obtained, which shows purely blue luminescence in film.
Article
Polymer Science
Masashi Nakamura, Momona Yamauchi, Masayuki Gon, Kazuo Tanaka
Summary: This study achieved efficient wavelength conversion from ultraviolet to near-infrared light by introducing pyrene into polymers, providing significant implications for the research of wavelength converting materials.
Review
Polymer Science
Kazuo Tanaka
Summary: A new method to control the electronic states of conjugated polymers without extending the pi-conjugated system was developed by aza-substitution of isolated frontier molecular orbitals (FMOs). This method efficiently and selectively lowers the energy level of FMOs, leading to the synthesis of materials with blue and near-infrared emitting properties.
Article
Polymer Science
Masayuki Gon, Misato Kanjo, Shunsuke Ohtani, Kazuo Tanaka, Yoshiki Chujo
Summary: This study demonstrated the synthesis of a new series of solid-state luminescent pi-conjugated polymers with tunable energy levels. These polymers exhibited intense luminescence in both solutions and films. By selectively perturbing the energy levels of the frontier molecular orbitals (FMOs) and utilizing condensed reagents in the azomethine bond formation reaction, the monomer structure and the perturbed FMOs could be determined.
Article
Chemistry, Physical
Junki Ochi, Takumi Yanagihara, Kazuo Tanaka, Yoshiki Chujo
Summary: We synthesized two types of regioisomers fused by a phenylnaphthalene ring with different connection points to the o-carborane scaffold. In this study, we investigated their photoluminescence properties and photochemical mechanisms in detail. Interestingly, despite having a common aromatic unit, they exhibited different photoluminescence characters in terms of wavelength and dual-emission, which were determined by the substitution position of aryl groups to o-carborane as indicated by variable-temperature photoluminescence measurements and quantum chemical calculations. It was further revealed that the relative position of the C-C bond of o-carborane and the aryl center played a crucial role in the photophysical events of aryl-o-carboranes.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Materials Science, Multidisciplinary
Shunya Tanaka, Daisuke Sakamaki, Naoki Haruta, Tohru Sato, Masayuki Gon, Kazuo Tanaka, Hideki Fujiwara
Summary: In this study, a novel double N,S-hetero[5]helicene composed of two benzo[b]phenothiazines was reported, which exhibited long-lived circularly polarized room-temperature phosphorescence. The intense and long-lived phosphorescence of the compound was explained by theoretical calculations. Optical resolution was successfully achieved, and the chiroptical properties of the compound were investigated. This compound represents a rare example of a purely-organic helicene that exhibits long-lived circularly polarized RTP from a non-aggregated state.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
Article
Engineering, Chemical
Yongxiang Wu, Nguyen Thi Hong Nhung, Deqian Zeng, Nengneng Luo, Akira Otsuki, Gjergj Dodbiba, Toyohisa Fujita
Summary: This study proposed a novel method for synthesizing flower-like vaterite calcium carbonate using nanobubble-containing ethanol and water mixed solution as the solvent and discussed the formation mechanism of vaterite with different shapes. The synthesized vaterite has significant practical interest in the integrated treatment of wastewater contaminated by heavy metals with effective Cd(II) removal, providing a promising field for studying heavy metal and pollutant adsorption in the liquid phase.
ADVANCED POWDER TECHNOLOGY
(2024)
Article
Engineering, Chemical
Jian Gong, Lipo Cheng, Ming Liu, Jie Jiang, Xiaoduo Ou
Summary: This study investigates the effects of particle shape on the collapse of granular columns using the discrete element method. The results show that particle shape has a significant impact on deposition morphology, energy evolution, and mechanical coordination number. Sphericity and angularity are identified as the most important macroscale factors, while roughness has a weaker microscale influence.
ADVANCED POWDER TECHNOLOGY
(2024)
