Journal
ADVANCED MATERIALS
Volume 30, Issue 39, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201803299
Keywords
emulsion interfacial polymerization; glycopeptide separation; heterostructured; nanopores; porous particles
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Funding
- National Natural Science Foundation of China [21425314, 21775148, 21504098, 51533007, 21434009, 21475129]
- Key Research Program of the Chinese Academy of Sciences [KJZD-EW-M01]
- MOST [2013YQ190467]
- Beijing Municipal Science & Technology Commission [Z161100000116037]
- Top-Notch Young Talents Program of China
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Porous polymer materials are extensively used for biomolecule separation. However, conventional homogeneous porous polymer materials cannot efficiently separate specific low-abundance biomolecules from complex samples. Here, particles fabricated by emulsion interfacial polymerization featuring heterostructured nanopores with tunable size are reported, which can be used to realize low-abundance glycopeptide (GP) separation from complex biofluids. The heterostructured surface inside the nanopores allows solvent-dependent local adsorption of biomolecules onto hydrophilic or hydrophobic regions. Low-abundance hydrophilic GPs in complex biofluids can be efficiently separated via the hydrophilic region of nanopores in low-polarity solvent after the hydrophobic region removes high-abundance hydrophobic proteins and non-glycopeptides in high-polarity solvent. It is expected that these particles with heterostructured nanopores can be used for separation of nucleic acids, saccharides, and proteins, and downstream clinical diagnosis.
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