Mucus Penetrating Nanoparticles: Biophysical Tool and Method of Drug and Gene Delivery

Biodegradable Nanoparticles Composed Entirely of Safe Materials that Rapidly Penetrate Human Mucus

(2011) Ming Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pluronic-based cationic block copolymer for forming pDNA polyplexes with enhanced cellular uptake and improved transfection efficiency

(2011) Tsz Chung Lai et al.   BIOMATERIALS

Highly compacted DNA nanoparticles with low MW PEG coatings: In vitro, ex vivo and in vivo evaluation

(2011) Nicholas J. Boylan et al.   JOURNAL OF CONTROLLED RELEASE

Non-degradative intracellular trafficking of highly compacted polymeric DNA nanoparticles

(2011) Anthony J. Kim et al.   JOURNAL OF CONTROLLED RELEASE

A poly(ethylene glycol)-based surfactant for formulation of drug-loaded mucus penetrating particles

(2011) Olcay Mert et al.   JOURNAL OF CONTROLLED RELEASE

N-acetylcysteine Enhances Cystic Fibrosis Sputum Penetration and Airway Gene Transfer by Highly Compacted DNA Nanoparticles

(2011) Jung Soo Suk et al.   MOLECULAR THERAPY

Rapid transport of muco-inert nanoparticles in cystic fibrosis sputum treated withN-acetyl cysteine

(2011) Jung Soo Suk et al.   Nanomedicine

Transport of metal oxide nanoparticles and single-walled carbon nanotubes in human mucus

(2011) Ashish Jachak et al.   Nanotoxicology

Common Gene Therapy Viral Vectors Do Not Efficiently Penetrate Sputum from Cystic Fibrosis Patients

(2011) Kaoru Hida et al.   PLoS One

Mucoadhesive Nanoparticles May Disrupt the Protective Human Mucus Barrier by Altering Its Microstructure

(2011) Ying-Ying Wang et al.   PLoS One

Biodegradable mucus-penetrating nanoparticles composed of diblock copolymers of polyethylene glycol and poly(lactic-co-glycolic acid)

(2011) Tao Yu et al.   Drug Delivery and Translational Research

Novel Approaches to Vaginal Delivery and Safety of Microbicides: Biopharmaceuticals, Nanoparticles, and Vaccines

(2010) Kevin J. Whaley et al.   ANTIVIRAL RESEARCH

Micro- and macrorheology of mucus

(2009) Samuel K. Lai et al.   ADVANCED DRUG DELIVERY REVIEWS

The penetration of fresh undiluted sputum expectorated by cystic fibrosis patients by non-adhesive polymer nanoparticles

(2009) Jung Soo Suk et al.   BIOMATERIALS

Mucins, Mucus, and Sputum

(2009) Judith A. Voynow et al.   CHEST

Human Immunodeficiency Virus Type 1 Is Trapped by Acidic but Not by Neutralized Human Cervicovaginal Mucus

(2009) S. K. Lai et al.   JOURNAL OF VIROLOGY

Long-term Transgene Expression in the Central Nervous System Using DNA Nanoparticles

(2009) David M Yurek et al.   MOLECULAR THERAPY

Altering Mucus Rheology to “Solidify” Human Mucus at the Nanoscale

(2009) Samuel K. Lai et al.   PLoS One

Ocular Delivery of Compacted DNA-Nanoparticles Does Not Elicit Toxicity in the Mouse Retina

(2009) Xi-Qin Ding et al.   PLoS One

Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier

(2009) B. C. Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanoparticles reveal that human cervicovaginal mucus is riddled with pores larger than viruses

(2009) S. K. Lai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene transfer to the lung: Lessons learned from more than 2 decades of CF gene therapy

(2008) Uta Griesenbach et al.   ADVANCED DRUG DELIVERY REVIEWS

Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues

(2008) Samuel K. Lai et al.   ADVANCED DRUG DELIVERY REVIEWS

Barrier properties of mucus

(2008) Richard A. Cone   ADVANCED DRUG DELIVERY REVIEWS

Extracellular barriers in respiratory gene therapy

(2008) Niek Sanders et al.   ADVANCED DRUG DELIVERY REVIEWS

Addressing the PEG Mucoadhesivity Paradox to Engineer Nanoparticles that “Slip” through the Human Mucus Barrier

(2008) Ying-Ying Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nanoparticles as protein and gene carriers to mucosal surfaces

(2008) Maria de la Fuente et al.   Nanomedicine