In Vivo Imaging of MMP-13 Activity Using a Specific Polymer-FRET Peptide Conjugate Detects Early Osteoarthritis and Inhibitor Efficacy

New approach for determining cartilage pore size distribution: NaCl-thermoporometry

(2017) D. Majda et al.   MICROPOROUS AND MESOPOROUS MATERIALS

Near-infrared activatable phthalocyanine-poly-L-glutamic acid conjugate: increased cellular uptake and light–dark toxicity ratio toward an effective photodynamic cancer therapy

(2017) Lik Voon Kiew et al.   Nanomedicine-Nanotechnology Biology and Medicine

The effect of polymer size and charge of molecules on permeation through synovial membrane and accumulation in hyaline articular cartilage

(2016) B. Sterner et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

MMP-13 is constitutively produced in human chondrocytes and co-endocytosed with ADAMTS-5 and TIMP-3 by the endocytic receptor LRP1

(2016) Kazuhiro Yamamoto et al.   MATRIX BIOLOGY

Ageing and the pathogenesis of osteoarthritis

(2016) Richard F. Loeser et al.   Nature Reviews Rheumatology

Emerging targets in osteoarthritis therapy

(2015) Mary B Goldring et al.   CURRENT OPINION IN PHARMACOLOGY

Discovery of N-(4-Fluoro-3-methoxybenzyl)-6-(2-(((2S,5R)-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide. A Highly Selective and Orally Bioavailable Matrix Metalloproteinase-13 Inhibitor for the Potential Treatment of Osteoarthritis

(2015) Peter G. Ruminski et al.   JOURNAL OF MEDICINAL CHEMISTRY

Osteoarthritis

(2015) S Glyn-Jones et al.   LANCET

Well-Defined Star-Shaped Polyglutamates with Improved Pharmacokinetic Profiles As Excellent Candidates for Biomedical Applications

(2015) Aroa Duro-Castano et al.   MOLECULAR PHARMACEUTICS

Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification

(2015) J. Larkin et al.   OSTEOARTHRITIS AND CARTILAGE

Analysis of the Trajectory of Osteoarthritis Development in a Mouse Model by Serial Near-Infrared Fluorescence Imaging of Matrix Metalloproteinase Activities

(2015) Averi A. Leahy et al.   Arthritis & Rheumatology

Halogen Bonding Controls Selectivity of FRET Substrate Probes for MMP-9

(2014) Isabelle Tranchant et al.   CHEMISTRY & BIOLOGY

Targeting a rare amyloidotic disease through rationally designed polymer conjugates

(2014) Inmaculada Conejos–Sánchez et al.   JOURNAL OF CONTROLLED RELEASE

Identification of Potent and Selective Hydantoin Inhibitors of Aggrecanase-1 and Aggrecanase-2 That Are Efficacious in Both Chemical and Surgical Models of Osteoarthritis

(2014) Timothy B. Durham et al.   JOURNAL OF MEDICINAL CHEMISTRY

In vivo imaging of MMP-13 activity in the murine destabilised medial meniscus surgical model of osteoarthritis

(2014) N.H. Lim et al.   OSTEOARTHRITIS AND CARTILAGE

A versatile post-polymerization modification method for polyglutamic acid: synthesis of orthogonal reactive polyglutamates and their use in “click chemistry”

(2013) Matthias Barz et al.   Polymer Chemistry

In Vivo Imaging of Matrix Metalloproteinase 12 and Matrix Metalloproteinase 13 Activities in the Mouse Model of Collagen-Induced Arthritis

(2013) Ngee Han Lim et al.   Arthritis & Rheumatology

Discovery of Highly Potent and Selective Small Molecule ADAMTS-5 Inhibitors That Inhibit Human Cartilage Degradation via Encoded Library Technology (ELT)

(2012) Hongfeng Deng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Proteases involved in cartilage matrix degradation in osteoarthritis

(2011) Linda Troeberg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Integrin-assisted drug delivery of nano-scaled polymer therapeutics bearing paclitaxel

(2011) Anat Eldar-Boock et al.   BIOMATERIALS

New Hope for the Treatment of Osteoarthritis Through Selective Inhibition of MMP-13

(2011) N.-G. Li et al.   CURRENT MEDICINAL CHEMISTRY

Activatable Optical Probes for the Detection of Enzymes

(2011) Christopher R. Drake et al.   CURRENT ORGANIC SYNTHESIS

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse

(2010) S.S. Glasson et al.   OSTEOARTHRITIS AND CARTILAGE

Matrix metalloproteinase 13–deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development

(2009) C. B. Little et al.   ARTHRITIS AND RHEUMATISM

Matrix metalloproteinases: Fold and function of their catalytic domains

(2009) Cynthia Tallant et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Novel selective MMP-13 inhibitors reduce collagen degradation in bovine articular and human osteoarthritis cartilage explants

(2009) Dorothea Piecha et al.   INFLAMMATION RESEARCH

Dark Quenched Matrix Metalloproteinase Fluorogenic Probe for Imaging Osteoarthritis Developmentin Vivo

(2008) Seulki Lee et al.   BIOCONJUGATE CHEMISTRY