Nanoparticle-mediated HMGA1 Silencing Promotes Lymphocyte Infiltration and Boosts Checkpoint Blockade Immunotherapy for Cancer

The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients

(2018) Vyara Matson et al.   SCIENCE

Synergistic and low adverse effect cancer immunotherapy by immunogenic chemotherapy and locally expressed PD-L1 trap

(2018) Wantong Song et al.   Nature Communications

A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer

(2017) Felipe de Sousa e Melo et al.   NATURE

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

(2017) Dung T. Le et al.   SCIENCE

HMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell niche

(2017) Lingling Xian et al.   Nature Communications

Comprehensive Meta-analysis of Key Immune-Related Adverse Events from CTLA-4 and PD-1/PD-L1 Inhibitors in Cancer Patients

(2017) Guillermo De Velasco et al.   Cancer Immunology Research

Facilitating T Cell Infiltration in Tumor Microenvironment Overcomes Resistance to PD-L1 Blockade

(2016) Haidong Tang et al.   CANCER CELL

Molecular Pathways: Immune Checkpoint Antibodies and their Toxicities

(2016) S. Cousin et al.   CLINICAL CANCER RESEARCH

Photodynamic Therapy Mediated by Nontoxic Core–Shell Nanoparticles Synergizes with Immune Checkpoint Blockade To Elicit Antitumor Immunity and Antimetastatic Effect on Breast Cancer

(2016) Xiaopin Duan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Local and transient gene expression primes the liver to resist cancer metastasis

(2016) T. J. Goodwin et al.   Science Translational Medicine

Spheroid-Formation (Colonosphere) Assay for in Vitro Assessment and Expansion of Stem Cells in Colon Cancer

(2016) Sameerah Shaheen et al.   Stem Cell Reviews and Reports

Spheroid-Formation (Colonosphere) Assay for in Vitro Assessment and Expansion of Stem Cells in Colon Cancer

(2016) Sameerah Shaheen et al.   Stem Cell Reviews and Reports

Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity

(2015) Santiago Zelenay et al.   CELL

PD-1/PD-L1 Blockade Together With Vaccine Therapy Facilitates Effector T-Cell Infiltration Into Pancreatic Tumors

(2015) Kevin C. Soares et al.   JOURNAL OF IMMUNOTHERAPY

Overexpression of HMGA1 correlates with the malignant status and prognosis of breast cancer

(2015) Ruixue Huang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

(2015) Dung T. Le et al.   NEW ENGLAND JOURNAL OF MEDICINE

HMGA1 silencing restores normal stem cell characteristics in colon cancer stem cells by increasing p53 levels

(2015) Francesca Puca et al.   Oncotarget

PD-1/SHP-2 Inhibits Tc1/Th1 Phenotypic Responses and the Activation of T Cells in the Tumor Microenvironment

(2014) J. Li et al.   CANCER RESEARCH

Indications and limitations of chemotherapy and targeted agents in non-small cell lung cancer brain metastases

(2014) Stefan Zimmermann et al.   CANCER TREATMENT REVIEWS

Regulatory T cells in cancer immunotherapy

(2014) Hiroyoshi Nishikawa et al.   CURRENT OPINION IN IMMUNOLOGY

Isolation of colorectal cancer stem-like cells

(2014) Eunice Dotse et al.   CYTOTECHNOLOGY

Methods for detecting circulating cancer stem cells (CCSCs) as a novel approach for diagnosis of colon cancer relapse/metastasis

(2014) Carla Kantara et al.   LABORATORY INVESTIGATION

PD-1 as an emerging therapeutic target in renal cell carcinoma: current evidence

(2014) Scott Tykodi   OncoTargets and Therapy

Development and characterization of a reliable mouse model of colorectal cancer metastasis to the liver

(2013) Yu Zhang et al.   CLINICAL & EXPERIMENTAL METASTASIS

Intravenous Delivery of siRNA Targeting CD47 Effectively Inhibits Melanoma Tumor Growth and Lung Metastasis

(2013) Yuhua Wang et al.   MOLECULAR THERAPY

Innate and adaptive immune cells in the tumor microenvironment

(2013) Thomas F Gajewski et al.   NATURE IMMUNOLOGY

The HMGA1-COX-2 axis: A key molecular pathway and potential target in pancreatic adenocarcinoma

(2013) Joelle Hillion et al.   PANCREATOLOGY

HMGA1 and HMGA2 protein expression correlates with advanced tumour grade and lymph node metastasis in pancreatic adenocarcinoma

(2012) Salvatore Piscuoglio et al.   HISTOPATHOLOGY

HMGA1 Induces Intestinal Polyposis in Transgenic Mice and Drives Tumor Progression and Stem Cell Properties in Colon Cancer Cells

(2012) Amy Belton et al.   PLoS One

Clinical Impact of Different Classes of Infiltrating T Cytotoxic and Helper Cells (Th1, Th2, Treg, Th17) in Patients with Colorectal Cancer

(2011) Marie Tosolini et al.   CANCER RESEARCH

COX-2 Blockade Suppresses Gliomagenesis by Inhibiting Myeloid-Derived Suppressor Cells

(2011) M. Fujita et al.   CANCER RESEARCH

HMGA and Cancer

(2010) Monica Fedele et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Safety and immunotoxicity assessment of immunomodulatory monoclonal antibodies

(2010) Frank R. Brennan et al.   mAbs

HMGA1 correlates with advanced tumor grade and decreased survival in pancreatic ductal adenocarcinoma

(2009) Alexandra C Hristov et al.   MODERN PATHOLOGY

The Acidic Tumor Microenvironment Promotes the Reconversion of Nitrite into Nitric Oxide: Towards a New and Safe Radiosensitizing Strategy

(2008) F. Frerart et al.   CLINICAL CANCER RESEARCH

HMGA1 Is a Molecular Determinant of Chemoresistance to Gemcitabine in Pancreatic Adenocarcinoma

(2008) S.-S. Liau et al.   CLINICAL CANCER RESEARCH