Review
Biochemistry & Molecular Biology
Julija G. Voicehovska, Dace Trumpika, Vladimirs V. Voicehovskis, Eva Bormane, Inara Busmane, Anda Grigane, Eva Moreino, Aivars Lejnieks
Summary: After the introduction of haemodialysis into clinical practice, a high risk of cardiac death was observed in end-stage renal disease patients. Recent research has shown that any renal injury is associated with high overall and cardiovascular lethality. Cardiorenal syndrome is a pathophysiological disorder where dysfunction in one organ leads to dysfunction in the other. Ultrafiltration as a component of renal replacement therapy has a beneficial effect on cardiac contractile function.
Article
Biochemistry & Molecular Biology
Chih-Hsiang Chang, Wei-Chiao Sun, Su-Wei Chang, Cheng-Chia Lee, Pei-Chun Fan, Huang-Yu Yang, Chih-Wei Yang
Summary: This study evaluated the impact of leptospirosis-associated acute kidney injury (AKI) on long-term kidney disease and mortality. The findings showed that patients with leptospirosis and AKI had a higher risk of long-term mortality and incidence of chronic kidney disease (CKD). Early detection and treatment of AKI in leptospirosis are crucial for improving long-term outcomes.
Article
Cardiac & Cardiovascular Systems
Darren Lau, Neesh Pannu, Matthew T. James, Brenda R. Hemmelgarn, Teresa M. Kieser, Steven R. Meyer, Scott Klarenbach
Summary: This study used a population-based cohort in Alberta, Canada to quantify the mortality and costs of varying degrees of AKI following cardiac surgery. The results showed that AKI was closely associated with outcomes and healthcare costs postcardiac surgery.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Review
Cell Biology
Neil G. Docherty, Christian Delles, Patrick D'Haese, Anita T. Layton, Carlos Martinez-Salgado, Benjamin A. Vervaet, Francisco J. Lopez-Hernandez
Summary: Haemodynamic frailty (HDF) in the elderly is a state of increased predisposition to disease, characterized by impairment of compensatory responses governing circulatory volume and adaptive haemodynamic function. Dehydration is a key factor in HDF, generating vulnerability to diseases caused by tissue hypoperfusion, including acute kidney injury. Mechanistic considerations highlight how dehydration impacts renal blood flow and increases the risk of AKI in the elderly, calling for further research on assessing and managing HDF to mitigate AKI risk.
AGEING RESEARCH REVIEWS
(2021)
Article
Urology & Nephrology
Lingyu Xu, Chenyu Li, Na Li, Long Zhao, Zhihui Zhu, Xiaosu Zhang, Jing Wang, Jun Zhao, Junyan Huang, Zhihua Zheng, Hans-Joachim Anders, Yan Xu
Summary: This study investigates the risk factors and prognosis of acute/subacute renal impairment among Chinese inpatients. It finds that AKI followed by AKD is associated with a higher risk of long-term mortality compared to AKD without AKI and recovery from AKI. The study also suggests that AKD criteria are strongly associated with overall survival and de novo CKD, while AKI criteria have a relatively lower ability to predict the risk of overall survival and CKD.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Medicine, General & Internal
Dan Liao, Yonghua Deng, Xinchun Li, Ju Huang, Jiayue Li, Ming Pu, Fenglian Zhang, Lijun Wang
Summary: This study found that elevated GNRI in critically ill patients is strongly correlated with a lower risk of unfavorable outcomes.
FRONTIERS IN MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Jiebin Hou, Xin Zhang, Zhen Wu, Yang Liu, Yabin Zhang, Jiahui Zhao, Xiaohua Wang, Hongyu Chen, Guang Yang, Qiang Ma, Qingli Cheng, Qiangguo Ao
Summary: Elderly patients with chronic heart failure (CHF) have a higher incidence of acute kidney injury (AKI), which can lead to poor prognosis. The relationship between kidney dysfunction and levels of N-terminal pro-brain natriuretic peptides (NT-proBNP) in elderly CHF patients has been analyzed in a retrospective cohort study. The results suggest that a decreased change in NT-proBNP during AKI can reduce the risk of more severe AKI and improve survival outcomes. However, an excessive decrease in NT-proBNP is a risk factor for non-recovery of renal function following AKI, especially in elderly survivors with low baseline NT-proBNP levels.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Urology & Nephrology
Qinglin Li, Zhi Mao, Hongjun Kang, Feihu Zhou
Summary: Recurrent AKI is common among elderly patients who recovered their renal function post-AKI and is associated with significantly higher 12-month mortality compared with CKD patients.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Article
Gastroenterology & Hepatology
Yi-Peng Wan, An-Jiang Wang, Wang Zhang, Hang Zhang, Gen-Hua Peng, Xuan Zhu
Summary: This study identified five potential risk factors for mortality in cirrhotic patients with AKI and established a diagnostic model to predict patient prognosis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Urology & Nephrology
Suchun Li, Qimei Luo, Yuting Fan, Chen Zhao, Fengxian Huang, Xi Xia, Wei Chen
Summary: This study found that lupus nephritis patients with acute kidney injury (AKI) had poorer long-term renal outcomes and patient survival. Early identification and management of AKI in these patients is crucial.
AMERICAN JOURNAL OF NEPHROLOGY
(2023)
Review
Gastroenterology & Hepatology
Kapil Gupta, Abhishek Bhurwal, Cindy Law, Scott Ventre, Carlos D. Minacapelli, Savan Kabaria, You Li, Christopher Tait, Carolyn Catalano, Vinod K. Rustgi
Summary: Acute kidney injury (AKI) in cirrhosis, including hepatorenal syndrome (HRS), is a common and serious complication leading to significant morbidity and mortality. AKI is categorized into non-HRS AKI and HRS-AKI, with liver transplantation being the ideal treatment option for HRS. Further research is needed to optimize treatment approaches for AKI in cirrhosis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Endocrinology & Metabolism
Manqiu Mo, Ling Pan, Zichun Huang, Yuzhen Liang, Yunhua Liao, Ning Xia
Summary: The study aimed to analyze the risk factors affecting all-cause mortality in diabetic patients with acute kidney injury and developed a prediction model for the 90-day survival rate of patients. The model showed good discrimination and calibration, indicating its clinical value in predicting patient outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Gastroenterology & Hepatology
Yasunari Hiramine, Hirofumi Uto, Seiichi Mawatari, Shuji Kanmura, Yasushi Imamura, Takuya Hiwaki, Akiko Saishoji, Manei Oku, Koichi Tokushige, Shigeho Maenohara, Akio Ido
Summary: In patients with hepatic ascites, the incidence of AKI is high and is associated with a significantly worse prognosis. The use of tolvaptan (TLV) in combination with diuretics may reduce the risk of AKI and have a synergistic therapeutic effect on hepatic ascites.
JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Urology & Nephrology
Ziv Harel, Eric McArthur, Nivethika Jeyakumar, Manish M. Sood, Amit X. Garg, Samuel A. Silver, Paul Dorian, Daniel Blum, William Beaubien-Souligny, Andrew T. Yan, Sunil V. Badve, Brendan Smyth, Min Jun, Racquel Jandoc, Abhijat Kitchlu, Ron Wald
Summary: In elderly individuals with atrial fibrillation, the use of direct oral anticoagulants is associated with a lower risk of acute kidney injury compared to warfarin. This lower risk is consistent across different eGFR levels and ranges of international normalized ratio measurements.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Martin Murgier, Laurent Bertoletti, Behnood Bikdeli, David Jimenez, Javier Trujillo-Santos, Adel Merah, Cristina de Ancos, Angeles Fidalgo, Jesus Aibar, Manuel Monreal
Summary: Risk stratification is important for patients with pulmonary embolism, and the presence of acute kidney injury (AKI) has been found to be associated with increased mortality and bleeding risk in all risk categories. Adding the AKI status to the sPESI score improves the prediction of 30-day mortality and may help identify low-risk patients suitable for home discharge.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2022)