Review
Cell Biology
Brianna N. Rogers, Jacqueline M. Stephens, Jenny L. Sones
Summary: Preeclampsia (PE) in pregnant women may be associated with obesity, leukocytosis, and impaired placental development. The use of rodent models can help to better understand the pathogenesis of PE.
PHYSIOLOGICAL GENOMICS
(2022)
Article
Obstetrics & Gynecology
Eliza C. Miller, Maria I. Katsidoniotaki, Noora Haghighi, Ketson R. M. Dos Santos, Whitney A. Booker, Nils Petersen, Ronald Wapner, Natalie A. Bello, Ioannis A. Kougioumtzoglou, Randolph S. Marshall
Summary: This study compared the changes in dynamic cerebral autoregulation (DCA) in postpartum individuals with and without preeclampsia with severe features (PSF) to healthy non-pregnant volunteers. The results showed that postpartum individuals, regardless of preeclampsia diagnosis, had higher phase shifts and higher gain compared to healthy non-pregnant/postpartum female volunteers, indicating impaired DCA function.
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2023)
Article
Neurosciences
Yonglin Xie, Wei He, Li Ma, Reng Ren, Shuxu Yang, Qin Lu
Summary: This study aimed to evaluate the role of TREM-1 on BBB permeability after ICH. The results showed that TREM-1 worsened BBB permeability by modulating the expression of interendothelial junction molecules after ICH, and this regulation is partly mediated by the SYK/beta-catenin signaling pathway.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Heon-Woo Lee, Yanying Xu, Xiaolong Zhu, Cholsoon Jang, Woosung Choi, Hosung Bae, Weiwei Wang, Liqun He, Suk-Won Jin, Zoltan Arany, Michael Simons
Summary: Endothelial cells rely on glycolysis for energy production, resulting in lactate production. Pericytes uptake endothelium-derived lactate and use it for energy generation and amino acid biosynthesis. The proximity between endothelial cells and pericytes is crucial for the transport of lactate. Inhibition of endothelial lactate production leads to blood-brain barrier breakdown, while lactate administration can restore these abnormalities to some extent.
Article
Obstetrics & Gynecology
Rebecca Horgan, Yara Hage Diab, Jerri Waller, Alfred Abuhamad, George Saade
Summary: The dosage and timing of aspirin initiation are crucial for reducing the risk of preeclampsia. Initiating a dosage of >100 mg of aspirin daily before 16 weeks' gestation seems to be the most effective approach. Randomized control trials are needed to evaluate the safety and efficacy of different aspirin dosages available in the United States.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Endocrinology & Metabolism
Mahboubeh Hajifoghaha, Saeed Hosseini Teshnizi, Sedighe Forouhari, Mohammad Hossein Dabbaghmanesh
Summary: This meta-analysis study assesses the abnormalities in thyroid function tests in preeclampsia. The findings indicate that preeclamptic women are at risk of changes in thyroid function tests. It is recommended to perform thyroid function tests in women with pre-eclampsia to prevent thyroid disorders.
BMC ENDOCRINE DISORDERS
(2022)
Review
Pharmacology & Pharmacy
Felix Neumaier, Boris D. Zlatopolskiy, Bernd Neumaier
Summary: Delivery of drugs to the central nervous system is hindered by the blood-brain barrier, necessitating a more holistic approach integrating various in vivo, in situ and in vitro assays to predict drug efficiency. Development of suitable in vitro BBB models may reduce late-stage failures in CNS drug development and address technical, economic, and ethical issues associated with in vivo animal studies.
Editorial Material
Urology & Nephrology
Amy Oi, Michelle A. Hladunewich
Summary: Following the Supreme Court's decision to overturn the right of American women to terminate pregnancy, vulnerable women, including those with chronic kidney disease, require increased care and attention. Nephrologists need to quickly develop expertise in reproductive care to ensure their health and well-being.
NATURE REVIEWS NEPHROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Anum S. Minhas, Xiumei Hong, Guoying Wang, Dong Keun Rhee, Tiange Liu, Mingyu Zhang, Erin D. Michos, Xiaobin Wang, Noel T. Mueller
Summary: This study found that self-reported higher adherence to a Mediterranean-style diet is associated with lower preeclampsia odds, and the benefit of this diet is present among Black women as well.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Neurosciences
Dan-Dan Zhu, Guang Yang, Yue-Lin Huang, Ting Zhang, Ao-Ran Sui, Na Li, Wei-Heng Su, Hai-Lun Sun, Jing-Jing Gao, Michael Ntim, Rong-Xiao Guan, Ling-Ling Jin, Jian Yu, Zhi-Yong Huang, Tong-Hui Ma, Shao Li
Summary: This study developed a mouse model with depolymerized orthogonal arrays of particles (OAPs) to investigate the importance of OAP formation in Aquaporin-4 (AQP4). The results showed that the OAP structure of AQP4 plays a key role in its polarized expression in astrocytic endfeet processes at the blood-brain barrier. Manipulating the OAP formation of AQP4 may provide a new intervention strategy for cerebral cellular edema caused by stroke and traumatic brain injury.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Medicine, General & Internal
Elzbieta Poniedzialek-Czajkowska, Radzislaw Mierzynski, Dominik Dluski, Bozena Leszczynska-Gorzelak
Summary: Hypertensive disorders of pregnancy, such as preeclampsia, pose significant risks to both mother and fetus. Aspirin is currently the only recommended pharmacological agent for prevention in high-risk groups, while metformin shows potential as an interesting option for prophylaxis, although further research is needed to clarify its effectiveness.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Dan Hua, Lida Tang, Weiting Wang, Shengan Tang, Lin Yu, Xuexia Zhou, Qian Wang, Cuiyun Sun, Cuijuan Shi, Wenjun Luo, Zhendong Jiang, Huining Li, Shizhu Yu
Summary: A novel dual-functional nanocomplex drug delivery system, SynB3-PVGLIG-PTX, was developed based on the strategy of peptide-drug conjugates. It exhibited specific inhibition on proliferation, migration, and invasion of GBM cells in vitro through the cleavage of MMP-2 to release PTX.
Article
Clinical Neurology
Eliza Miller, Anni E. Kauko, Sarah Tom, Hannele Laivuori, Teemu A. Niiranen, Natalie Bello
Summary: The study found that adverse pregnancy outcomes are associated with an earlier onset of maternal cerebrovascular disease, especially in cases where women had more than one affected pregnancy.
Article
Neurosciences
Yibin Zhao, Lin Gan, Li Ren, Yubo Lin, Congcong Ma, Xianming Lin
Summary: The blood-brain barrier (BBB) is a dynamic structure that protects the brain and maintains a stable microenvironment. Various cellular components and structural elements contribute to the integrity of the BBB. Transporters and transcytosis regulate the movement of substances, and differences in localization and expression affect transport properties. Inflammation and other factors can alter BBB permeability by influencing structural components and barrier function. Understanding the factors influencing BBB permeability is important for identifying potential therapeutic targets for protecting the BBB and delivering drugs to the central nervous system.
Article
Obstetrics & Gynecology
Matthew P. Brohan, Fionn P. Daly, Louise Kelly, Fergus P. Mccarthy, Ali S. Khashan, Karolina Kublickiene, Peter M. Barrett
Summary: This systematic review examines the association between hypertensive disorders of pregnancy and the long-term risk for maternal stroke. The results show that exposure to hypertensive disorders of pregnancy, particularly preeclampsia and gestational hypertension, is associated with an increased risk for any stroke and ischemic stroke among parous patients in later life.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Editorial Material
Neurosciences
Junie P. Warrington
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Meeting Abstract
Biochemistry & Molecular Biology
Parminder Vig, Jung Ryu, H. Lee, Junie Warrington, Amol Janorkar, Pallabi Pal, Mariper Lopez
Meeting Abstract
Biochemistry & Molecular Biology
Junie Warrington, Qingmei Shao, Ahsia Clayton, Kenji Maeda, Michael Garrett, Jennifer Sasser
Meeting Abstract
Biochemistry & Molecular Biology
Maria Jones-Muhammad, Qingmei Shao, Rachael Thompson, Junie Warrington
Meeting Abstract
Biochemistry & Molecular Biology
Akia Sherrod, Qingmei Shao, Rachael Thompson, Ashley Griffin, Maria Muhammad, Junie Warrington
Article
Cardiac & Cardiovascular Systems
Kenji J. Maeda, Daniel M. McClung, Kurt C. Showmaker, Junie P. Warrington, Michael J. Ryan, Michael R. Garrett, Jennifer M. Sasser
Summary: Preeclampsia is characterized by hypertension and proteinuria in late pregnancy, with potential neurological symptoms like headaches and vision problems. Using animal models is essential to understanding the pathogenesis of this condition.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Cell Biology
Maria Jones-Muhammad, Qingmei Shao, Loretta Cain-Shields, James P. Shaffery, Junie P. Warrington
Summary: Eclampsia is a condition that can cause seizures in pregnant women. Research on a rat model of reduced uterine perfusion pressure (RUPP) showed that decreased levels of ASIC2a in the hippocampus may contribute to increased seizure sensitivity. Decreased ASIC2a levels could potentially alter intracellular acid-base balance, leading to an increased risk of seizures during pregnancy.
Editorial Material
Cardiac & Cardiovascular Systems
Maria Jones-Muhammad, Junie P. Warrington
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Editorial Material
Physiology
Maria Jones-Muhammad, Junie P. Warrington
PHYSIOLOGICAL REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Junie P. Warrington, Qingmei Shao, Ahsia M. Clayton, Kenji J. Maeda, Ashtin G. Beckett, Michael R. Garrett, Jennifer M. Sasser
Summary: Microglia, the resident immune cells of the central nervous system, have been found to be associated with pial vessels in the brains of Dahl-SS/Jr rats with chronic hypertension. These pial vessel-associated microglia (PVAM) have a higher density and are closer together compared to Sprague Dawley rats. The functional role of these cells is unknown, but they may have an origin in the Dahl-SS/Jr model of chronic hypertension.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Austin T. Robinson, Nathaniel D. M. Jenkins, Sofia O. Sanchez, Karla K. V. Haack, Dexter L. Lee, Keisa W. Mathis, Junie P. Warrington
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Junie P. Warrington, Maria Jones-Muhammad, Rachael O. Thompson, Tyranny Pryor, Qingmei Shao, Manasa Gunturu
Summary: Structural changes in the retinal vasculature were observed in multiparous females compared to nulliparous females and male breeders. Multiparous females had higher body mass, heart weight, and kidney weight, while venous pericyte density decreased. The time elapsed since delivery is an important factor to be considered in multiparity studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Maria Jones-Muhammad, Tyranny Pryor, Qingmei Shao, Kevin B. Freeman, Junie P. Warrington
Summary: The mechanisms contributing to increased risk of seizures in preeclampsia are not fully known. This study suggests that reduced uterine perfusion pressure (RUPP) leads to changes in hippocampal CB1R expression and manipulating CB1R activity can change seizure severity in RUPP mice.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Maria Jones-Muhammad, Qingmei Shao, Junie Warrington
Meeting Abstract
Biochemistry & Molecular Biology
Ashtin Beckett, Ahsia Clayton, Qingmei Shao, Kenji Maeda, Michael Garrett, Jennifer Sasser, Junie Warrington