Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 69, Issue -, Pages 67-80Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.addr.2013.12.002
Keywords
Renal; Polycystic kidney disease; 3D tissues; Microfluidics; Glomerulus; Drug-induced nephrotoxicity; Acute kidney injury; Chronic kidney disease; Renal fibrosis; Renal cell carcinoma
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Funding
- NIH Tissue Engineering Resource Center [P41 EB002520]
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Renal disease represents a major health problem that often results in end-stage renal failure necessitating dialysis and eventually transplantation. Historically these diseases have been studied with patient observation and screening, animal models, and two-dimensional cell culture. In this review, we focus on recent advances in tissue engineered kidney disease models that have the capacity to compensate for the limitations of traditional modalities. The cells and materials utilized to develop these models are discussed and tissue engineered models of polycystic kidney disease, drug-induced nephrotoxicity, and the glomerulus are examined in detail. The application of these models has the potential to direct future disease treatments and predinical drug development (C) 2013 Elsevier B.V. All rights reserved.
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