Article
Biochemistry & Molecular Biology
Soheil Kazemi Roodsari, Yan Cheng, Kirstin M. Reed, Laurie L. Wellman, Larry D. Sanford, Woong-Ki Kim, Ming-Lei Guo
Summary: Sleep disorders and drug addiction are highly correlated and function as major risk factors for drug addiction. Recent studies have shown that both sleep disorders and drug abuse could activate microglia and increase neuroinflammation, which play critical roles in the pathogenesis of both diseases. Through experiments using a mouse model, it was found that sleep fragmentation (SF) can attenuate the psychoactive effects of cocaine by modulating neuroimmune and dopamine signaling. These findings suggest that sleep disorders may mediate the connection between sleep disorders and drug addiction by affecting neuroimmune and dopamine signaling in the brain reward circuitry.
Article
Biology
Xiaojie Liu, Casey R. Vickstrom, Hao Yu, Shuai Liu, Shana Terai Snarrenberg, Vladislav Friedman, Lianwei Mu, Bixuan Chen, Thomas J. Kelly, David A. Baker, Qing-song Liu
Summary: This study demonstrates that Epac2 in the mesolimbic dopamine system promotes cocaine reinforcement by enhancing dopamine release. Conditional knockout or inhibition of Epac2 reduces cocaine self-administration in mice, while Epac2 agonism increases dopamine release. This mechanism plays a crucial role in the reinforcing effects of cocaine.
Article
Pharmacology & Pharmacy
Lidia E. W. Spelta, Yuli Y. S. Torres, Sarah C. W. S. E. F. de Oliveira, Mauricio Yonamine, Alexis Bailey, Rosana Camarini, Raphael C. T. Garcia, Tania Marcourakis
Summary: This study demonstrates that cocaine use induces plastic changes in the hippocampal cholinergic muscarinic system, while withdrawal leads to a resetting of the system.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Review
Neurosciences
Melinda Hersey, Amanda K. Bacon, Lydia G. Bailey, Mark A. Coggiano, Amy H. Newman, Lorenzo Leggio, Gianluigi Tanda
Summary: The rapid increase in individuals affected by psychostimulant use disorder (PSUD) has highlighted the potential of Modafinil (MOD) as a therapeutic option due to its non-addictive properties, despite its similar mechanism of action to commonly abused psychostimulants on the dopamine transporter (DAT). Clinical and preclinical studies have demonstrated the efficacy of MOD in treating symptoms related to PSUD and other psychiatric disorders involving alterations of brain dopamine systems.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Eric Y. Choi, Daniela Franco, Catherine A. Stapf, Madeleine Gordin, Amanda Chow, Kara K. Cover, Ramesh Chandra, Mary Kay Lobo
Summary: Substance use disorder is a chronic disease with significant impact on global disability. This study investigates the molecular and functional changes in the NAc associated with cocaine exposure, specifically in D1-MSNs and D2-MSNs. Using CRISPR tools, the researchers mimic the expression patterns of Nab2 and Egr3 in these neurons and shed light on their role in cocaine action.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Soo Min Lee, Han Byeol Jang, Yu Fan, Bong Hyo Lee, Sang Chan Kim, Kyle B. Bills, Scott C. Steffensen, Hee Young Kim
Summary: Nociceptive signals modulate the mesolimbic reward system, possibly through the involvement of the lateral hypothalamus (LH) and lateral habenula (LHb). Stimulation by tail pinch excites LHb and LH neurons, leading to increased inhibitory activity on the mesolimbic dopamine (DA) system. This inhibition is essential for attenuating cocaine-induced behaviors and drug reinstatement.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Marta Pardo, Michele Martin, Raul R. Gainetdinov, Deborah C. Mash, Sari Izenwasser
Summary: This study used a DAT transgenic rat model to investigate the effects of cocaine on locomotor behaviors in adolescent rats. The results showed gender differences in vulnerability to cocaine abuse in adolescence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Guilian Tian, May Hui, Desiree Macchia, Pieter Derdeyn, Alexandra Rogers, Elizabeth Hubbard, Chengfeng Liu, Jose J. Vasquez, Lara Taniguchi, Katrina Bartas, Sean Carroll, Kevin T. Beier
Summary: This study reveals the selective role of ventral tegmental area dopamine projection to the amygdala in cocaine-induced anxiety. The activity of inhibitory GABAergic cells and downstream dopamine cells in the bed nucleus of the stria terminalis and amygdala is elevated even after a single cocaine exposure. Silencing this projection prevents the development of anxiety during protracted withdrawal after cocaine administration. Furthermore, the activation of dopamine cells in the amygdala is necessary and sufficient for reinstatement of cocaine place preference.
Article
Cell Biology
Wei Wang, Xueyi Xie, Xiaowen Zhuang, Yufei Huang, Tao Tan, Himanshu Gangal, Zhenbo Huang, William Purvines, Xuehua Wang, Alexander Stefanov, Ruifeng Chen, Lucas Rodriggs, Anita Chaiprasert, Emily Yu, Valerie Vierkant, Michelle Hook, Yun Huang, Emmanuel Darcq, Jun Wang
Summary: Withdrawal from chronic opioid use leads to hypodopaminergic states and negative affect, promoting relapse. Activation of MORs in dMSNs in the striatal patch compartment suppresses striatopallidal transmission, and withdrawal potentiated this transmission. Fentanyl self-administration enhances striatonigral transmission and reduces dopaminergic activity, while activated striatal neurons mediate contextual memory retrieval. Inhibition of striatal MOR+ neurons rescues fentanyl withdrawal-induced physical symptoms and anxiety-like behaviors. These findings suggest that chronic opioid use induces GABAergic striatopallidal and striatonigral plasticity, leading to hypodopaminergic states and relapse.
Article
Multidisciplinary Sciences
Julong Wei, Tova Y. Lambert, Aditi Valada, Nikhil Patel, Kellie Walker, Jayna Lenders, Carl J. Schmidt, Marina Iskhakova, Adnan Alazizi, Henriette Mair-Meijers, Deborah C. Mash, Francesca Luca, Roger Pique-Regi, Michael J. Bannon, Schahram Akbarian
Summary: This study found that chronic exposure to opioids results in broad transcriptional changes in glial cells, including upregulation of genes associated with immune response and downregulation of synaptic signaling and plasticity genes. It also identified certain genes that are linked to risk of substance use in the population.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Ma Luisa Soto-Montenegro, Veronica Garcia-Vazquez, Nicolas Lamanna-Rama, Gonzalo Lopez-Montoya, Manuel Desco, Emilio Ambrosio
Summary: Vulnerability to addiction is associated with the risk of developing an addiction during an individual's lifetime. This study used PET and SPM techniques to investigate changes in brain glucose metabolism in response to chronic morphine self-administration in two rat strains with different vulnerability to drug abuse. The results showed significant differences in brain metabolic patterns between the two strains, suggesting variations in the efficiency of neural substrates in translating the effects of the drug.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Khaled Khader Z. Alatawi, Khalid Saleh D. Albalawi, Abdulrhman Abdulaziz M. Aljuhani, Nader Salem D. Albalawi, Adel Ibrahim Alalawy, Atif Abdulwahab A. Oyouni
Summary: Drug addiction is a serious social issue that affects the individuals, families, and society as a whole. This article reviews the causes of addiction, absorption of methamphetamine, its effects on cells, and the analytical tools for detection.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Jason Yuen, Abhinav Goyal, Aaron E. Rusheen, Abbas Z. Kouzani, Michael Berk, Jee Hyun Kim, Susannah J. Tye, Charles D. Blaha, Kevin E. Bennet, Dong-Pyo Jang, Kendall H. Lee, Hojin Shin, Yoonbae Oh
Summary: For over 40 years, in vivo microdialysis techniques have been crucial in studying the effects of illicit substances on dopamine levels in the brain, but limitations have led to the development of a new electrochemical method known as M-CSWV. This method provides faster recordings of dopamine level changes, allowing for a more detailed understanding of neuronal responses to drug administration.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Idaira Oliva, Melissa M. Donate, Merridee J. Lefner, Matthew J. Wanat
Summary: Research shows that acute stress affects dopamine-dependent behaviors through activating CRF signaling in the ventral tegmental area (VTA), leading to suppression of motivation for food rewards but promotion of drug-seeking behavior. Additionally, prior drug experience may alter how CRF regulates motivation for food rewards in the VTA.
Article
Biochemistry & Molecular Biology
Daniel R. Garton, Giorgio Turconi, Vilma Iivanainen, Jaan-Olle Andressoo
Summary: Cocaine addiction is a serious and deadly condition without effective pharmacological treatments. The neurotrophic factor GDNF and its receptor RET may be a promising approach to treating psychostimulant addiction. In this study, reducing RET expression in the VTA accelerates extinction of conditioned place preference and reduces reinstatement, while reducing GDNF in the NAc prolongs conditioned place preference and increases preference during reinstatement. This suggests that RET antagonism in the VTA and intact or enhanced GDNF function in the NAc could be a new approach for treating cocaine addiction.
Article
Neurosciences
Keren Bachi, Muhammad A. Parvaz, Scott J. Moeller, Gabriela Gan, Anna Zilverstand, Rita Z. Goldstein, Nelly Alia-Klein
FRONTIERS IN HUMAN NEUROSCIENCE
(2018)
Article
Psychology, Clinical
Scott J. Moeller, David S. Fink, Misato Gbedemah, Deborah S. Hasin, Sandro Galea, Michael J. Zvolensky, Renee D. Goodwin
JOURNAL OF CLINICAL PSYCHIATRY
(2018)
Review
Behavioral Sciences
Zoe Guttman, Scott J. Moeller, Edythe D. London
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2018)
Article
Multidisciplinary Sciences
Nelly Alia-Klein, Rebecca N. Preston-Campbell, Scott J. Moeller, Muhammad A. Parvaz, Keren Bachi, Gabriela Gan, Anna Zilverstand, Anna B. Konova, Rita Z. Goldstein
Article
Clinical Neurology
Scott J. Moeller, Martin P. Paulus
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2018)
Article
Substance Abuse
Murat Yucel, Erin Oldenhof, Serge H. Ahmed, David Belin, Joel Billieux, Henrietta Bowden-Jones, Adrian Carter, Samuel R. Chamberlain, Luke Clark, Jason Connor, Mark Daglish, Geert Dom, Pinhas Dannon, Theodora Duka, Maria Jose Fernandez-Serrano, Matt Field, Ingmar Franken, Rita Z. Goldstein, Raul Gonzalez, Anna E. Goudriaan, Jon E. Grant, Matthew J. Gullo, Robert Hester, David C. Hodgins, Bernard Le Foll, Rico S. C. Lee, Anne Lingford-Hughes, Valentina Lorenzetti, Scott J. Moeller, Marcus R. Munafo, Brian Odlaug, Marc N. Potenza, Rebecca Segrave, Zsuzsika Sjoerds, Nadia Solowij, Wim van den Brink, Ruth J. van Holst, Valerie Voon, Reinout Wiers, Leonardo F. Fontenelle, Antonio Verdejo-Garcia
Article
Neurosciences
Ryan M. Sullivan, Greg Perlman, Scott J. Moeller
EUROPEAN JOURNAL OF NEUROSCIENCE
(2019)
Article
Neurosciences
Andy C. Dean, Erika L. Nurmi, Scott J. Moeller, Nader Amir, Michelle Rozenman, Dara G. Ghahremani, Maritza Johnson, Robert Berberyan, Gerhard Hellemann, Ziwei Zhang, Edythe D. London
PSYCHOPHARMACOLOGY
(2019)
Article
Psychology, Clinical
Scott J. Moeller, Adam W. Hanley, Eric L. Garland
PSYCHOLOGICAL MEDICINE
(2020)
Article
Substance Abuse
Scott J. Moeller, Prantik Kundu, Keren Bachi, Thomas Maloney, Pias Malaker, Muhammad A. Parvaz, Nelly Alia-Klein, Edythe D. London, Rita Z. Goldstein
DRUG AND ALCOHOL DEPENDENCE
(2020)
Review
Psychiatry
Antonio Verdejo-Garcia, Valentina Lorenzetti, Victoria Manning, Hugh Piercy, Raimondo Bruno, Rob Hester, David Pennington, Serenella Tolomeo, Shalini Arunogiri, Marsha E. Bates, Henrietta Bowden-Jones, Salvatore Campanella, Stacey B. Daughters, Christos Kouimtsidis, Dan I. Lubman, Dieter J. Meyerhoff, Annaketurah Ralph, Tara Rezapour, Hosna Tavakoli, Mehran Zare-Bidoky, Anna Zilverstand, Douglas Steele, Scott J. Moeller, Martin Paulus, Alex Baldacchino, Hamed Ekhtiari
FRONTIERS IN PSYCHIATRY
(2019)
Article
Substance Abuse
Scott J. Moeller, Jonathan M. Platt, Melody Wu, Renee D. Goodwin
DRUG AND ALCOHOL DEPENDENCE
(2020)
Article
Neurosciences
Nelly Alia-Klein, Rebecca N. Preston-Campbell, Sung Won Kim, Deborah Pareto, Jean Logan, Gene-Jack Wang, Scott J. Moeller, Joanna S. Fowler, Anat Biegon
FRONTIERS IN NEUROSCIENCE
(2020)
Article
Psychology, Clinical
Renee D. Goodwin, Scott J. Moeller, Jiaqi Zhu, Jeremy Yarden, Sarah Ganzhorn, Jill M. Williams
Summary: The use of cocaine without heroin declined overall from 2002 to 2017, but showed an increasing trend from 2011. In contrast, the co-use of heroin and cocaine, as well as heroin use without cocaine, showed a linear increase during the same period. It is important for screening, outreach, clinical treatment, and first responders to be aware of the increasing trends in polysubstance use and the potential impact of co-use of heroin and cocaine on intervention and overdose outcomes in the US.
ADDICTIVE BEHAVIORS
(2021)
Letter
Substance Abuse
Scott J. Moeller, Anissa Abi-Dargham
AMERICAN JOURNAL ON ADDICTIONS
(2019)