Article
Psychology, Biological
Ya Zheng, Puyu Shi, Leyou Deng, Huiping Jiang, Shiyu Zhou
Summary: This study investigated the effects of contextual valence on neural dynamics underlying magnitude and time during feedback evaluation. The results showed distinct processing patterns for time and magnitude information in the gain and loss contexts, providing a novel perspective on the gain-loss asymmetry.
Article
Psychology, Multidisciplinary
Afework Tsegaye, Cuiling Guo, Renata Cserjesi, Leon Kenemans, Gijsbert Stoet, Gyongyi Kokonyei, Alexander Logemann
Summary: The study found that smokers showed reduced inhibitory control in contexts of reward, leading to faster response times, indicating an enhanced approach bias to reward-related stimuli. This suggests that smokers may have difficulty in controlling their impulses in rewarding situations, possibly due to heightened sensitivity to rewards.
BEHAVIORAL SCIENCES
(2021)
Review
Psychology, Biological
Alice Ely, Reagan R. Wetherill
Summary: Cigarette smoking and obesity are leading causes of premature morbidity and mortality, with a four-fold increased risk of all-cause mortality when comorbid. This review explores the impact of reward and inhibition in cigarette smoking and obesity separately, as well as the influence of increased body mass index (BMI) on neurocognitive function in smokers. Chronic smoking and overeating of palatable food may disrupt reward neurocircuitry, leading to diminished inhibitory control and potential cross-use. Changes in reward and inhibitory function due to BMI increase may also hinder smoking cessation among individuals with obesity and smoking comorbidity.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Neurosciences
Hannah J. Zhang, Matthew Zammit, Chien-Min Kao, Anitha P. Govind, Samuel Mitchell, Nathanial Holderman, Mohammed Bhuiyan, Richard Freifelder, Anna Kucharski, Xiaoxi Zhuang, Jogeshwar Mukherjee, Chin-Tu Chen, William N. Green
Summary: The distribution of nicotine and other nicotinic receptor ligands in the brain is investigated. Ligands with high pKa and affinity for cc4P2Rs, like varenicline, are trapped in intracellular acidic vesicles in vitro, while nicotine, with lower pKa and affinity, is not trapped. In vivo imaging of PET ligands in mouse brain reveals that the trapping organelle is Golgi satellites (GSats) and provides insights into the subcellular distribution of these ligands.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Genetics & Heredity
Ahmet Muderrisoglu, Elif Babaoglu, Elif Tugce Korkmaz, Said Kalkisim, Erdem Karabulut, Salih Emri, Melih O. Babaoglu
Summary: In this study, smoking cessation treatment with varenicline was significantly more effective than treatments with nicotine replacement therapy or bupropion in Turkish subjects. Regardless of carrying wild-type or variant alleles, subjects with human nicotinic acetylcholine receptor subunits alpha 3, alpha 4, and alpha 5 showed similar clinical outcomes and smoker/non-smoker status in response to pharmacological treatments.
FRONTIERS IN GENETICS
(2022)
Article
Psychology, Biological
Roberto U. Cofresi, Thomas M. Piasecki, Greg Hajcak, Bruce D. Bartholow
Summary: This study found that individual differences in P3 signals elicited by alcohol cues are highly reliable and stable over 8-10 months, while individual differences in alcohol cue-specific P3 reactivity are less reliable and stable. The conditions under which neural signals specific to alcohol/drug cues are adequately reliable and stable remain unknown.
Article
Multidisciplinary Sciences
Harry Tattan-Birch, Jamie Brown, Lion Shahab, Sarah E. Jackson
Summary: This study found that refillable tank e-cigarettes remain the most widely used device type in England, despite the growing popularity of pods and HTPs worldwide.
SCIENTIFIC REPORTS
(2021)
Review
Health Care Sciences & Services
Merel Keijsers, Maria Cecilia Vega-Corredor, Melanie Tomintz, Simon Hoermann
Summary: Virtual reality technologies have been proposed to enhance smoking cessation therapy, with cue exposure therapy being the most studied intervention. However, the long-term effects are inconsistent. Behavioral therapies like approach-avoidance tasks or gamified interventions have shown positive results.Future research should focus on multicomponent interventions and include control groups for validity.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Neurosciences
Nitsan Goldstein, Jamie R. E. Carty, J. Nicholas Betley
Summary: This study demonstrates that varenicline enhances the suppression of nicotine-induced dopamine (DA) release by attenuating DA neuron activity in the ventral tegmental area (VTA), highlighting the specific effect of varenicline on nicotine reward. The results also emphasize the complexity of different rewards in activating the mesolimbic DA system.
Article
Substance Abuse
Humairah Arshad, Sarah E. Jackson, Loren Kock, Charlotte Ide-Walters, Harry Tattan-Birch
Summary: Despite increasing evidence that e-cigarettes are less harmful than cigarettes, perceptions of equal or more harm have been on the rise worldwide. This study aims to identify the common reasons behind adults' perceptions of the relative harm of e-cigarettes compared with cigarettes and the effectiveness of e-cigarettes for smoking cessation. The study recruited 1646 adults from Northern England and analyzed their open-ended responses to understand the reasons behind their perceptions.
DRUG AND ALCOHOL DEPENDENCE
(2023)
Review
Substance Abuse
Eric C. Donny, Cassidy M. White
Summary: Reducing nicotine content in cigarettes to very low levels could benefit public health by decreasing smoking prevalence, reducing cigarette consumption, and increasing smoking cessation. This strategy may have similar positive effects across various populations of smokers, but there could also be negative outcomes such as withdrawal symptoms and the emergence of illicit markets.
INTERNATIONAL JOURNAL OF DRUG POLICY
(2022)
Article
Substance Abuse
Kuang Hock Lim, Yoon Ling Cheong, Norhalina Sulaiman, Xin Yun Yah, Mas Eliana Mahadzir, Jia Hui Lim, Chee Cheong Kee, Sumarni Mohd Ghazali, Hui Li Lim
Summary: This study compared the level of agreement between FTND and HSI in detecting high nicotine dependence among daily smokers, and found that HSI had substantial agreement with FTND in measuring high levels of nicotine addiction.
TOBACCO INDUCED DISEASES
(2022)
Article
Substance Abuse
Sheng Zhi Zhao, Yongda Wu, Derek Yee Tak Cheung, Tzu Tsun Luk, Xue Weng, Henry Sau Chai Tong, Vienna Lai, Sophia Siu Chee Chan, Tai Hing Lam, Man Ping Wang
Summary: This study examines the trends in the prevalence of hardening indicators and hardened smokers in Hong Kong. The findings suggest that, although smoking prevalence has not decreased in the past decade, the proportion of smokers who are resistant to quitting has increased, and their perceived importance and confidence in quitting have decreased. Effective tobacco control policies and interventions are needed to motivate smokers to quit and further reduce smoking prevalence.
Article
Substance Abuse
Alexander A. Brown, Spencer Upton, Stephen Craig, Brett Froeliger
Summary: This study found that the cortical thickness and volume of different subregions of the right inferior frontal gyrus were associated with inhibitory control among individuals with nicotine dependence. The results indicate that the cortical thickness of distinct subregions in the right inferior frontal gyrus may serve as biomarkers for unique forms of inhibitory control deficits.
DRUG AND ALCOHOL DEPENDENCE
(2023)
Article
Substance Abuse
Anthony C. Oliver, Michael DeSarno, Charles G. Irvin, David Kaminsky, Jennifer W. Tidey, Stacey C. Sigmon, Sarah H. Heil, Diann E. Gaalema, Dustin Lee, Janice Y. Bunn, Danielle R. Davis, Joanna M. Streck, Thomas Gallagher, Stephen T. Higgins
Summary: This study investigated the effects of reduced-nicotine-content cigarettes on respiratory health in smokers with affective disorders, opioid use disorder (OUD), or socioeconomic disadvantage over a 12-week period. Results showed that FeNO levels were higher in participants with affective disorders and socioeconomic disadvantage assigned to RNCCs compared to those assigned to higher nicotine content, while no significant changes were found in RHQ scores.
NICOTINE & TOBACCO RESEARCH
(2022)
Article
Psychology, Biological
Heather E. Webber, Constanza de Dios, Margaret C. Wardle, Robert Suchting, Charles E. Green, Joy M. Schmitz, Scott D. Lane, Francesco Versace
Summary: Individuals with cocaine use disorder (CUD) exhibit different neuroaffective profiles in response to drug-related cues, which may be linked to their attribution of incentive salience to cues. Considering these individual differences during treatment may help clinicians tailor treatments and increase treatment success.
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
(2022)
Article
Behavioral Sciences
Rafael Delgado-Rodriguez, Francesco Versace, Isabel Hernandez-Rivero, Pedro Guerra, M. Carmen Fernandez-Santaella, Laura Miccoli
Summary: This study found that women who attribute high incentive salience to food-related cues report higher food addiction symptoms, with this difference reflected in neuroaffective reactivity. The results support the hypothesis that individual differences in the tendency to attribute incentive salience to food cues play an important role in modulating food addiction symptomatology.
Article
Substance Abuse
Jason D. Robinson, Yong Cui, Maher Karam-Hage, George Kypriotakis, Francesco Versace, Nassima Ait-Daoud Tiouririne, Robert M. Anthenelli, Paul M. Cinciripini
Summary: The study found that high-dose topiramate can reduce the motivational salience of drug-related and emotional cues among smokers with AUD. However, it remains unclear whether this effect represents one of topiramate's therapeutic mechanisms of action.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Substance Abuse
Jason D. Robinson, Yong Cui, Paulina Linares Abrego, Jeffrey M. Engelmann, Alexander Prokhorov, Damon J. Vidrine, Sanjay Shete, Paul M. Cinciripini
Summary: This study suggests that 2 weeks of attentional bias modification training on a smartphone does not have an additive benefit for quitting smoking beyond what is provided by nicotine replacement therapy and counseling. Although the training reduced attentional bias to smoking cues, it did not concurrently decrease smoking behavior or craving.
PSYCHOLOGY OF ADDICTIVE BEHAVIORS
(2022)
Article
Oncology
Akshara Singareeka Raghavendra, George Kypriotakis, Maher Karam-Hage, Seokhun Kim, Mazen Jizzini, Kareem S. Seoudy, Jason D. Robinson, Carlos H. Barcenas, Paul M. Cinciripini, Debu Tripathy, Nuhad K. Ibrahim
Summary: This retrospective analysis looks at breast cancer patients who smoked at the time of diagnosis and participated in a comprehensive tobacco treatment program. The study found that quitting smoking is linked to better survival outcomes across all tumor stages for these patients. Comprehensive smoking cessation programs may improve survival when initiated early on at diagnosis.
Article
Psychology, Biological
Francesco Versace, Nicola Sambuco, Menton M. Deweese, Paul M. Cinciripini
Summary: To create reproducible emotional probes, affective scientists rely on standardized pictures normed using subjective ratings. However, when investigating emotional responses using neurophysiological measures, it might be more appropriate to select pictures integrating normed subjective reports and normed neurophysiological responses.
Article
Substance Abuse
Lindsey N. Potter, Chelsey R. Schlechter, Inbal Nahum-Shani, Cho Y. Lam, Paul M. Cinciripini, David W. Wetter
Summary: This study investigates whether the within-person associations of key risk and protective factors with smoking lapse varies by facets of socio-economic status (SES). The findings suggest that individuals from lower SES groups have a weaker influence of some risk factors on smoking lapse compared to higher SES groups.
Article
Substance Abuse
Francesco Versace, George Kypriotakis, Dustin Pluta
Summary: This study examined the association between neuroaffective responses to motivationally salient stimuli and vulnerability to cue-induced e-cigarette use in e-cigarette naive adults who smoke daily. Results showed that individuals with stronger neuroaffective responses to nicotine-related cues than to pleasant stimuli (C>P profile) were more vulnerable to cue-induced nicotine self-administration than individuals with stronger neuroaffective responses to pleasant stimuli than to nicotine-related cues (P>C profile).
DRUG AND ALCOHOL DEPENDENCE
(2023)
Article
Health Care Sciences & Services
Paul M. Cinciripini, Jennifer A. Minnix, Jason Robinson, George Kypriotakis, Yong Cui, Janice A. Blalock, Cho Y. Lam, David W. Wetter
Summary: This study evaluates the effectiveness of scheduled smoking in combination with precessation nicotine replacement therapy (NRT) compared with standard NRT for quitting smoking. The results demonstrate that scheduled smoking with precessation NRT can significantly increase abstinence rates and reduce nicotine withdrawal symptoms and cravings, providing a better overall quitting experience and encouraging future quit attempts.
JMIR FORMATIVE RESEARCH
(2023)
Meeting Abstract
Psychology, Biological
Francesco Versace, Nicola Sambuco, Menton Deweese, Paul Cinciripini
Article
Substance Abuse
Jaqueline C. Avila, Carla J. Berg, Jason Robinson, Jasjit S. Ahluwalia
Summary: There is mixed evidence regarding whether older (vs. younger) smokers are more or less likely to quit smoking. This study found that older smokers were more likely to have 12-month cigarette and tobacco abstinence than younger smokers, and the effect of age on abstinence differed by smoking frequency/intensity. Smoking cessation interventions need to be age specific and consider the smoking frequency/intensity of each age group.
NICOTINE & TOBACCO RESEARCH
(2022)
Article
Health Care Sciences & Services
Yong Cui, Jason D. D. Robinson, Rudel E. E. Rymer, Jennifer A. A. Minnix, Paul M. M. Cinciripini
Summary: With the use of the Qualtrics platform, researchers can conduct mobile smoking cessation and outcome evaluation research without the need for a dedicated application. The platform provides capabilities for data collection, personalized behavioral interventions, and integration of complex behavioral and cognitive tasks, offering a novel and cost-effective approach for researchers.
FRONTIERS IN DIGITAL HEALTH
(2022)