Review
Biochemistry & Molecular Biology
Amir Asgari, Paul Jurasz
Summary: Megakaryocytes are important members of the hematopoietic system, responsible for regulating vascular homeostasis through platelets. The process of megakaryopoiesis generates mature megakaryocytes which release proplatelets into blood vessels. Nitric oxide (NO) plays a modulatory role in hematopoiesis and hemostasis. This review summarizes the effect of NO and its signaling on megakaryopoiesis and thrombopoiesis under physiological and pathophysiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
George J. Dugbartey
Summary: Kidney transplantation is the preferred treatment for patients with kidney failure. However, ischemia-reperfusion injury (IRI) poses a significant challenge to the long-term success of this intervention. Nitric oxide (NO) has emerged as a potential candidate for mitigating IRI and preventing graft rejection in kidney transplantation. This review provides an overview of the sources and protective effects of endogenous and exogenous NO in kidney transplantation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Fabio Arias, Francisco Franco-Montalban, Miguel Romero, Juan Duarte, M. Dora Carrion, M. Encarnacion Camacho
Summary: This paper describes the design, synthesis, and biological evaluation of selective inhibitors of inducible nitric oxide synthase (iNOS). The most potent and selective compound showed inhibitory activity against iNOS without undesirable cardiovascular effects. In silico analysis predicted good drug-likeness properties for promising compounds, which also exhibited adequate cell viability. Docking studies revealed a unique binding mode for one compound and explained its selectivity towards iNOS.
BIOORGANIC CHEMISTRY
(2022)
Editorial Material
Plant Sciences
Francisco J. Corpas, Salvador Gonzalez-Gordo, Jose M. Palma
Summary: Nitric oxide is a crucial signaling molecule in plant physiological processes, but the enzymatic generation of nitric oxide in higher plants is still controversial.
TRENDS IN PLANT SCIENCE
(2022)
Article
Medicine, Research & Experimental
Joao Victor Silva-Silva, Carla J. Moragas-Tellis, Maria S. S. Chagas, Paulo Victor R. Souza, Davyson L. Moreira, Celeste S. F. de Souza, Kerolain F. Teixeira, Arthur R. Cenci, Aldo S. de Oliveira, Fernando Almeida-Souza, Maria D. Behrens, Katia S. Calabrese
Summary: This study evaluated the leishmanicidal activity of a crude extract and anthocyanidin-rich fractions from Arrabidaea chica, as well as three isolated anthocyanidins. The results showed promising anti-leishmanial effects of these compounds, indicating their potential as therapeutic agents for leishmaniasis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Tatsiana Suvorava, Sara Metry, Stephanie Pick, Georg Kojda
Summary: Vascular tone regulation by nitric oxide is a crucial physiological function, with endothelial dysfunction potentially being an underlying cause of hypertension. Increasing eNOS activity reduces blood pressure, while decreasing activity has the opposite effect. These findings have important implications for pre-hypertensive treatment.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Divya Seth, Colin T. Stomberski, Precious J. McLaughlin, Richard T. Premont, Kathleen Lundberg, Jonathan S. Stamler
Summary: The aim of this study was to investigate the interactions between nitric oxide synthase (NOS) isoforms and proteins, as well as the mechanisms by which they mediate S-nitrosylation. The results showed that each NOS isoform interacts with and S-nitrosylates many proteins, but a large proportion of S-nitrosylated proteins are not associated with NOS. Additionally, the interactomes and S-nitrosylomes of individual NOS isoforms are largely unique, indicating specific roles for each isoform in S-nitrosylation.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Horticulture
Sitthisak Intarasit, Bualuang Faiyue, Jamnong Uthaibutra, Kobkiat Saengnil
Summary: The research aimed to investigate the impact of chlorine dioxide (ClO2) on the browning of longan pericarp. The findings indicated that ClO2 fumigation reduced the activities of RNS producing enzymes, resulting in lower nitrosative stress levels and reduced pericarp browning.
SCIENTIA HORTICULTURAE
(2022)
Article
Biochemistry & Molecular Biology
Shinya Yokomizo, Malte Roessing, Atsuyo Morita, Timo Kopp, Emiyu Ogawa, Wataru Katagiri, Susanne Feil, Paul L. Huang, Dmitriy N. Atochin, Satoshi Kashiwagi
Summary: This study provides evidence that NIR-II laser enhances bioavailable NO in endothelial cells, suggesting its potential use in restoring endothelial NO and treating or preventing cardiovascular diseases.
Article
Biochemistry & Molecular Biology
Tijana Suboticki, Olivera Mitrovic Ajtic, Dragoslava Djikic, Marijana Kovacic, Juan F. Santibanez, Milica Tosic, Vladan P. Cokic
Summary: In various systems, hydroxyurea has been shown to stimulate the release of nitric oxide or activate nitric oxide synthase. Through inhibiting nitric oxide metabolites, hydroxyurea is able to inhibit the growth of mature erythroid colonies and impact the presence of iNOS immunoreactive CFU-E.
Article
Pharmacology & Pharmacy
Shang Xian Bo, Wang Yan Jie, Cai De Chao, Ma Sai, Wang Zhe, Zhu Ya Kun, Guo Hui Hui, Wang Chen, Ma Xiao, Hu Zhong Yao, Yu Hao Ran, Zhang Ji Sen, Cheng Wen Dan
Summary: The study demonstrated that compound 22o effectively inhibited the inflammatory response and catabolism of chondrocytes, reducing articular cartilage injury in a rat OA model induced by ACLT. The compound showed potential as a disease-modifying OA drug.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Stanislava Vrankova, Zuzana Galandakova, Jakub Benko, Martina Cebova, Igor Riecansky, Olga Pechanova
Summary: The results of the study indicate that 10 weeks of social isolation led to a significant decrease in PPI, accompanied by a decrease in NOS activity in the cerebral cortex and the cerebellum, an increase in iNOS in the hippocampus, and an increase in CD concentration in cortex homogenate. On the other hand, 29 weeks of social isolation had an opposite effect on NOS activity, with an increase in the cerebral cortex and the cerebellum in animals reared in a social environment, accompanied by a decrease in CD concentration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Soo Hee Lee, Seong-Ho Ok, Seung Hyun Ahn, Hyun-Jin Kim, Sung Il Bae, Ji-Yoon Kim, Kyeong-Eon Park, Yeran Hwang, Ju-Tae Sohn
Summary: This study found that lipid emulsion enhanced the vasoconstriction induced by dexmedetomidine by inhibiting nitric oxide synthesis, potentially through reducing dexmedetomidine concentration. Dexmedetomidine-induced nitric oxide synthesis may be caused by Src kinase-induced caveolin-1 phosphorylation leading to increased eNOS (Ser1177) phosphorylation and decreased eNOS (Thr495) phosphorylation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Han-Yan Zhu, Fen-Fang Hong, Shu-Long Yang
Summary: Vascular dementia is the second most common form of dementia worldwide, caused by cerebrovascular disease. Nitric oxide and nitric oxide synthase play vital roles in the pathogenesis of this disease, with different NOS subtypes having partitioned activities in the brain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Prabha Panneerselvan, Keerthana Vasanthakumar, Karthi Muthuswamy, Vasanth Krishnan, Selvakumar Subramaniam
Summary: Nitric oxide has a dual impact on cancer, with both anti-tumor and pro-tumor effects. It regulates various mechanisms in the tumor microenvironment, such as metabolism, cell cycle, and apoptosis, to modulate tumor growth.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Cell Biology
Jerome Mallefet, Laurent Duchatelet, Claire Hermans, Fernand Baguet
Article
Marine & Freshwater Biology
Laurent Duchatelet, Julien M. Claes, Jerome Mallefet
Article
Biochemistry & Molecular Biology
Nicolas Oury, Laurent Duchatelet, Jerome Mallefet, Helene Magalon
MOLECULAR BIOLOGY REPORTS
(2019)
Article
Zoology
Laurent Duchatelet, Nicolas Pinte, Taketeru Tomita, Keiichi Sato, Jerome Mallefet
ZOOLOGICAL LETTERS
(2019)
Article
Cell Biology
Laurent Duchatelet, Jerome Delroisse, Patrick Flammang, Jacques Mahillon, Jerome Mallefet
Article
Biochemistry & Molecular Biology
Laurent Duchatelet, Jerome Delroisse, Nicolas Pinte, Keiichi Sato, Hsuan-Ching Ho, Jerome Mallefet
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Nicolas Pinte, Mathilde Godefroid, Ouissam Abbas, Vincent Baeten, Jerome Mallefet
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2019)
Article
Marine & Freshwater Biology
Laurent Duchatelet, Jerome Delroisse, Jerome Mallefet
Article
Multidisciplinary Sciences
Severine Martini, Linda Kuhnz, Jerome Mallefet, Steven H. D. Haddock
SCIENTIFIC REPORTS
(2019)
Article
Biology
Jerome Mallefet, Laurent Duchatelet, Constance Coubris
JOURNAL OF EXPERIMENTAL BIOLOGY
(2020)
Article
Biodiversity Conservation
Laurent Duchatelet, Hsuan-Ching Ho, Jerome Mallefet
Summary: Bioluminescence is a common phenomenon in marine organisms, and luminescent sharks use counterillumination for camouflage. Recent research has revealed a new method of controlling luminescence in sharks and found that this method is expressed during the development of luminescent organs. Comparative studies of different shark families show that they share similar patterns of light perception, supporting the evolutionary conservation of luminescent organ morphogenesis.
Article
Fisheries
Laurent Duchatelet, Charlotte Nuyt, Nathan Puozzo, Jerome Mallefet, Jerome Delroisse
Summary: This study compares the light organ ultrastructure of Dalatias licha with that of Etmopterus spinax to understand the light emission process and its conservation within shark families. The photophores of Dalatias licha are simpler than those of Etmopterus spinax. Stimulation experiments suggest that light emission may occur in a specific area filled with granular inclusions.
Article
Biology
Laurent Duchatelet, Constance Coubris, Christopher Pels, Sam T. Dupont, Jerome Mallefet
Summary: Bioluminescence is an important ecological feature for many marine species. Recent research has discovered a mechanism in benthic anthozoans where neurotransmitters, particularly adrenaline, play a role in controlling light emission.
Review
Marine & Freshwater Biology
Laurent Duchatelet, Julien M. M. Claes, Jerome Delroisse, Patrick Flammang, Jerome Mallefet
Summary: This review provides a synthesis of knowledge on shark bioluminescence, focusing on the distribution and unique luminescence control mechanism of bioluminescent sharks. It also discusses potential areas for future research on shark luminescence.
OCEANS-SWITZERLAND
(2021)
Article
Multidisciplinary Sciences
Julien M. Claes, Jerome Delroisse, Mark A. Grace, Michael H. Doosey, Laurent Duchatelet, Jerome Mallefet
SCIENTIFIC REPORTS
(2020)