Article
Materials Science, Multidisciplinary
Francesca Salamanna, Nicolandrea Del Piccolo, Maria Sartori, Gianluca Giavaresi, Lucia Martini, Giuseppe Di Sante, Cesare Stagni, Dante Dallari, Milena Fini
Summary: The study suggests that the combination of autologous activated PRP, as a carrier for BMSCs, is a promising regenerative strategy for bone formation, osseointegration, and mineralization of bone implants.
Article
Engineering, Biomedical
Marjan Bahraminasab, Nesa Doostmohammadi, Athar Talebi, Samaneh Arab, Akram Alizadeh, Ali Ghanbari, Amir Salati
Summary: In this study, the properties of 3D-printed PLA scaffolds were improved by infilling them with gelatin-nano-hydroxyapatite (PLA/G-nHA) and subsequent coating with PRP. The scaffolds were evaluated for printing accuracy, structural characterizations, mechanical properties, degradability behavior, cell adhesion, mineralization, systemic effect on liver enzymes, osteocalcin level in blood serum, and in vivo bone regeneration capability. The results showed that PLA/G-nHA/PRP scaffolds had high printing accuracy, superior cell proliferation and adhesion, and better bone regeneration capability compared to bare PLA and PLA/G-nHA scaffolds.
BIOMEDICAL ENGINEERING ONLINE
(2022)
Review
Biochemistry & Molecular Biology
Khalid Saad Alharbi, Waleed Hassan Almalki, Sami I. Alzarea, Imran Kazmi, Fahad A. Al-Abbasi, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Sachin Kumar Singh, Kamal Dua, Gaurav Gupta
Summary: Current studies have found that Piezo1 plays an important role in the heart, closely related to cardiac regeneration and angiogenesis, providing new research directions for cardiomyocyte regeneration.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Surgery
Pietro Gentile, Simone Garcovich
Summary: This article reviews the literature on the efficacy of autologous activated platelet-rich plasma (PRP) and nonactivated PRP injection for facial rejuvenation. Eleven out of twelve studies showed improved results, despite differences in study design and outcome measures. However, further randomized controlled trials and systematic reviews are needed to confirm the efficacy of PRP injection in facial rejuvenation.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Polymer Science
Michelangelo Palco, Paolo Rizzo, Giorgio Carmelo Basile, Angelo Alito, Daniele Bruschetta, Maria Accorinti, Roberto Restuccia, Danilo Leonetti
Summary: This study compared the effectiveness of L-PRP and PRP+HA in patients with mild to moderate HOA, finding that both treatments were effective in reducing pain, with L-PRP showing better results in reducing VAS over time, making it a potentially preferred treatment option. Further research is needed to better describe the clinical outcome of these formulations.
Review
Cell Biology
Giuseppina Malcangi, Assunta Patano, Giulia Palmieri, Chiara Di Pede, Giulia Latini, Alessio Danilo Inchingolo, Denisa Hazballa, Elisabetta de Ruvo, Grazia Garofoli, Francesco Inchingolo, Gianna Dipalma, Elio Minetti, Angelo Michele Inchingolo
Summary: This review examines the potentials of concentrated growth factors in maxillary sinus lift technique. The use of platelet concentrates can promote bone remodeling, reduce the amount of autologous bone required during surgery, enhance early vascularization in bone grafts, and stimulate the regeneration of injured tissues. Further studies are still needed, but the use of platelet concentrates can improve clinical results in sinus elevation surgeries by improving bone height, thickness, and vascularization of surgical sites, and promoting post-operative healing.
Article
Medicine, General & Internal
Julia Vidan-Estevez, Sergio Sanchez-Herraez, Fernando Escalante-Barrigon, Jesus Seco-Calvo
Summary: The study on treating chronic non-healing wounds with al-PRP showed that treatment duration significantly influenced wound healing, with the best results seen in cases where treatment extended beyond 13 weeks.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Kaitlyn E. Whitney, Grant J. Dornan, Jillian King, Jorge Chahla, Thos A. Evans, Marc J. Philippon, Robert F. LaPrade, Johnny Huard
Summary: This study compared fresh and freeze-thawed PRP preparations and found significant changes in matrix metalloproteinase (MMP) concentrations. MMPs play a crucial role in the remodeling phase of musculoskeletal injury.
Article
Dermatology
Nilhan Atsu, Cansu Ekinci-Aslanoglu, Busra Kantarci-Demirkiran, Nazli Caf, Fadime Nuhoglu
Summary: This study aimed to compare the efficacy, patient satisfaction, and side effects of PRP and PRF injection treatments for facial skin rejuvenation. PRF showed a slight superiority over PRP in the canthal region at three months, but this advantage disappeared later during the treatment. PRF may be a viable alternative to PRP for that indication.
DERMATOLOGIC THERAPY
(2023)
Article
Mathematical & Computational Biology
Zhu Xu, Han Hu, Bin Wu, Chenglong Huang, Qin Liu, Bin Chen
Summary: Through meta-analysis of multiple studies, it was found that PRP adjuvant therapy is effective in treating fracture patients, especially beneficial for mandibular fracture patients, and can reduce the risk of revision surgery for fracture patients.
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
(2022)
Article
Obstetrics & Gynecology
Yanhong Mao, Mei Wang, Yao Xiong, Xue Wen, Ming Zhang, Ling Ma, Yuanzhen Zhang
Summary: This study investigated the therapeutic effects and possible mechanisms of platelet-rich plasma (PRP) on endometrial regeneration. The results showed that PRP promotes endometrium regeneration by up-regulating the retinol metabolism and extracellular matrix receptor interaction pathway with MELTF. Meanwhile, PRP could also inhibit endometrial epithelial cell death by regulating ferroptosis, autophagy, and pyroptosis.
REPRODUCTIVE SCIENCES
(2023)
Article
Veterinary Sciences
Alessio Franini, Maria Grazia Entani, Elisa Colosio, Luca Melotti, Marco Patruno
Summary: In this case report, a 7-year-old male Whippet competing in lure-coursing exhibited third-degree recurrent lameness in the right forelimb, with pain and swelling in the caudal aspect of the carpus. Conservative treatments such as NSAIDs administration, palmar splint application, and rest were ineffective. The dog received autologous PRP injections followed by PL injections at three-week intervals. Clinical and ultrasonographic assessments showed improvements in lameness and healing of the tendinopathy. The combination treatment of autologous PRP and PL for FCU tendinopathy in lure-coursing dogs was found to be feasible with no adverse reactions.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Eduardo Anitua, Ander Pino, Mikel Azkargorta, Felix Elortza, Roberto Prado
Summary: The composition differences between autologous topical serum (ES) and leukocyte- and platelet-rich plasma (L-PRP) lead to different responses in human dermal fibroblasts (HDFs). ES treatment promotes protein synthesis, cell proliferation, and migration, while L-PRP treatment induces a response similar to proinflammatory molecules.
Article
Engineering, Biomedical
Bianza Moise Bakadia, Abeer Ahmed Qaed Ahmed, Lallepak Lamboni, Zhijun Shi, Biampata Mutu Mukole, Ruizhu Zheng, Mazono Pierre Mbang, Bi Zhang, Mario Gauthier, Guang Yang
Summary: The management of diabetic wounds is a challenge, but platelet-rich plasma (PRP) gel, PRP-derived exosomes (PRP-Exos), and mesenchymal stem cell-derived exosomes (MSC-Exos) have potential in wound treatment. However, their limitations include poor mechanical properties, short half-lives of growth factors (GFs), burst release of GFs and exosomes, and protease degradation. To overcome these limitations, dual-crosslinked hydrogels based on silk protein (SP) were developed, which showed improved mechanical properties and sustained release of GFs and exosomes. These hydrogels promoted diabetic wound healing by upregulating GF expression, down-regulating matrix metalloproteinase-9 expression, and promoting angiogenesis and re-epithelialization.
BIOACTIVE MATERIALS
(2023)
Article
Surgery
Edward S. Chamata, Erica L. Bartlett, David Weir, Rod J. Rohrich
Summary: Platelet-rich plasma is widely used in plastic surgery for treating alopecia and skin rejuvenation, showing therapeutic advantages when combined with laser skin treatment and fat grafting. Despite variability in processing and preparation methods, there is convincing evidence of positive outcomes with objective measurement modalities.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Article
Medicine, General & Internal
Natasa Pejcic, Milica Duric-Jovicic, Nadica Miljkovic, Dejan B. Popovic, Vanja Petrovic
SRPSKI ARHIV ZA CELOKUPNO LEKARSTVO
(2016)
Article
Veterinary Sciences
S. Jankovic, Z. Aleksic, Jakoba Natasa Nikolic, D. Stanimirovic, Z. Stojic, Ana Pucar, M. Hadzi-Mihailovic
ACTA VETERINARIA-BEOGRAD
(2010)
Article
Veterinary Sciences
R. Zivkovic, Mirjana Peric, Valentina Arsic-Arsenijevic, Z. Martinovic, Marina Pekmezovic, Z. Stojic, Vanja Raickovic, S. Durisic
ACTA VETERINARIA-BEOGRAD
(2013)
Article
Agronomy
Ivana Ilic Dimitrijevic, Thomas Loening, Marcus Falk, Vitomir S. Konstantinovic, Miroslav Vukadinovic, Zvezdana Tepavcevic, Sasa Tabakovic, Natasa Pejcic, Biljana Milicic, Jelena Milasin
Article
Dentistry, Oral Surgery & Medicine
Natasa Pejcic, Vanja Petrovic, Milica Duric-Jovicic, Natasa Medojevic, Angelina Nikodijevic-Latinovic
Summary: Dentistry is a high-risk profession for work-related disorders, and dental students are also exposed to risk factors. The study aimed to determine and localize musculoskeletal pain during dental work, providing suggestions for effective preventive measures. Results showed that neck muscle activity poses a high ergonomic risk, and students should be aware of potential risks and engage in regular physical activity to avoid ergonomic problems.
EUROPEAN JOURNAL OF DENTAL EDUCATION
(2021)
Article
Environmental Sciences
Boris Djuran, Zoran Tatic, Neda Perunovic, Natasa Pejcic, Jovana Vukovic, Aleksandra Petkovic-Curcin, Danilo Vojvodic, Mia Rakic
Summary: Peri-implant diseases are a growing public health problem, and the limitations of standard diagnostics are considered to be a contributing factor. This study aimed to estimate the pathological bone resorption at clinical and biological levels in patients with peri-implant mucositis and peri-implantitis before and after standard treatment and compare them with healthy controls.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Review
Medicine, General & Internal
Mia Rakic, Natasa Pejcic, Neda Perunovic, Danilo Vojvodic
Summary: Periodontitis is a common health condition with serious socio-economic impacts, requiring efficient strategies for prevention and management. Current periodontal diagnosis is limited by clinical and radiological parameters, leading to the introduction of biomarkers for precision periodontics. However, the implementation of precision medicine in periodontology is still in its initial stages.
MEDICINA-LITHUANIA
(2021)
Article
Public, Environmental & Occupational Health
Natasa Pejcic, Vanja Petrovic, Dejan Markovic, Biljana Milicic, Ivana Ilic Dimitrijevic, Neda Perunovic, Sasa Cakic
WORK-A JOURNAL OF PREVENTION ASSESSMENT & REHABILITATION
(2017)
Article
Medicine, Research & Experimental
Vanja Petrovic, Natasa Pejcic, Sasa Cakic
ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
(2013)