Article
Biotechnology & Applied Microbiology
Jing Liu, Keli Gao, Dingwei Li, Yang Zeng, Xueyang Chen, Xiongyan Liang, Chun Fang, Yufang Gu, Chunfeng Wang, Yuying Yang
Summary: This study demonstrated that the recombinant invasive Lactobacillus plantarum NC8 expressing Gp85 protein of ALV-J could enhance the immune responses in chickens, leading to increased protection against ALV-J infection. This provides a novel method for exploring live vaccines against ALV-J.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Veterinary Sciences
Moru Xu, Fusen Hang, Kun Qian, Hongxia Shao, Jianqiang Ye, Aijian Qin
Summary: This report describes a disease characterized by hepatomegaly and splenomegaly in chickens that is closely associated with a novel strain of ALV-J. Other viruses were ruled out as the cause of the disease, highlighting the importance of an ALV-J eradication program.
BMC VETERINARY RESEARCH
(2022)
Article
Veterinary Sciences
Yuan Chen, Hong-wei Li, Feng Cong, Yue-xiao Lian
Summary: This study used a nontargeted metabolomics approach to identify differential metabolites in plasma samples from ALV-J-infected chickens. The results showed significant alterations in metabolite levels in infected chickens compared to healthy controls, suggesting potential biomarkers for ALV-J-induced metabolic changes. These findings provide valuable insights into the metabolic effects of ALV-J infection.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Moru Xu, Xiaohui Mu, Kun Qian, Hongxia Shao, Yongxiu Yao, Venugopal Nair, Jian Wang, Jianqiang Ye, Aijian Qin
Summary: Avian leukosis virus was detected and isolated from Tibetan chickens for the first time, showing specific genetic characteristics in subgroup J which may confer competitive advantages over other strains in the future.
Article
Agriculture, Dairy & Animal Science
Jing Li, Lanlan Liu, Xinxin Niu, Jiukuan Li, Zhonghui Kang, Chunyan Han, Yulong Gao, Xiaole Qi, Yongqiang Wang, Xiaomei Wang, Xiangwei Zeng
Summary: Research indicated that the DL00766 strain may be an AVL subgroup E isolate with a subgroup B-like gp85 region. This is the first discovery of the E subgroup being used as a recombinant subject, while the subgroup B provides a recombinant virus with an exogenous gene.
Article
Agriculture, Dairy & Animal Science
Houkun Wang, Xueyang Chen, Lilin Zhu, Xiaowei Fang, Keli Gao, Chun Fang, Jing Liu, Yufang Gu, Xiongyan Liang, Yuying Yang
Summary: This study successfully prepared a monoclonal antibody specific for ALV-J and identified a new epitope of ALV-J Gp85. This finding may assist in the development of specific ALV-J detection methods.
Article
Virology
Liqin Liao, Weiguo Chen, Xiangyu Zhang, Huanmin Zhang, Aijun Li, Yiming Yan, Zi Xie, Hongxing Li, Wencheng Lin, Jingyun Ma, Xinheng Zhang, Qingmei Xie
Summary: This study discovered a novel means of vertical transmission for ALV-J by utilizing host semen extracellular vesicles, and demonstrated the feasibility of this transmission method.
Article
Microbiology
Xiaoyun Qu, Xiaobo Li, Ziwei Li, Ming Liao, Manman Dai
Summary: In this study, the researchers used single-cell RNA sequencing to study the peripheral blood mononuclear cells (PBMCs) of chickens infected with a specific virus, identifying different cell populations and their gene expression profiles. They found that T cells had the strongest response to the infection and could be further divided into four subsets. They also observed changes in the composition of PBMCs and identified potential key effectors against the virus. This study provides valuable insights into the function of chicken PBMC subsets in both normal and viral infection conditions.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Virology
Qiaomu Deng, Min Li, Chengwei He, Qiaoe Lu, Yanli Gao, Qiuhong Li, Mengya Shi, Peikun Wang, Ping Wei
Summary: Avian leukosis virus subgroup J (ALV-J) has caused significant economic losses in China by infecting various birds. In-depth analysis of the genetic diversity of ALV-J revealed that current Chinese strains are mainly in Clade 1.3, while Chinese and Egyptian chicken flocks are encountering emerging Clade 2 viruses. The proposed unified classification system for ALV-J will facilitate future studies on epidemiology, genetic evolution, and sequence comparison worldwide.
Article
Multidisciplinary Sciences
Haiqin Li, Meifang Tan, Fanfan Zhang, Huayuan Ji, Yanbing Zeng, Qun Yang, Jia Tan, Jiangnan Huang, Qi Su, Yu Huang, Zhaofeng Kang
Summary: This study conducted a systematic epidemiological survey in local chicken flocks in Jiangxi Province, China and isolated 71 strains from 560 samples, with different molecular features belonging to subgroup J, suggesting that local chickens may have long been reservoirs for various ALV-J strains. The research also revealed the emergence of novel strains forming separate evolutionary branches, indicating the breeding of new mutated ALVs in local chickens.
SCIENTIFIC REPORTS
(2021)
Article
Virology
Weiguo Chen, Sheng Chen, Yu Nie, Wenxue Li, Hongxin Li, Xinheng Zhang, Feng Chen, Qingmei Xie
Summary: In recent years, superinfections of avian leukosis virus subgroup J (ALV-J) and infectious bursal disease virus (IBDV) have become more frequent in nature, resulting in increased pathogenicity in infected chickens. This study demonstrates an effective candidate model for studying the outcomes of superinfections with ALV-J and IBDV. The results show that superinfections lead to severe immunosuppression and enhanced viral replication, which contribute to the increased pathogenicity.
Article
Biotechnology & Applied Microbiology
Y. Chen, H. Li
Summary: The study found that ALV-J infection alters the gut microbiota in chickens, disrupting the host-microbial homeostasis which may be involved in the pathogenesis of ALV-J infection.
LETTERS IN APPLIED MICROBIOLOGY
(2022)
Article
Microbiology
Liqin Liao, Zhiqiang Wu, Weiguo Chen, Huanmin Zhang, Aijun Li, Yiming Yan, Zi Xie, Hongxin Li, Wencheng Lin, Jingyun Ma, Xinheng Zhang, Qingmei Xie
Summary: Control of ALV-J in chicken breed is a serious issue that needs more attention. The elimination of vertical transmission of ALV-J is not yet well understood, and effective vaccines or drugs have not been developed. This study found that anti-CD81 antibody can inhibit viral infection and prevent vertical transmission of ALV-J in an animal model.
VETERINARY MICROBIOLOGY
(2022)
Article
Microbiology
Sheng Chen, Yiming Yan, Liguo Gao, Shuang Gao, Keyu Feng, Hongxin Li, Xinheng Zhang, Weiguo Chen, Feng Chen, Qingmei Xie
Summary: In this study, proteomic analysis revealed that 53 cellular proteins are incorporated into mature ALV-J virions, with potential functions in the viral life cycle and tumorigenesis. These findings provide new insights into the interaction between ALV-J and its host, and shed light on the cellular requirements for ALV-J infection.
VETERINARY MICROBIOLOGY
(2023)
Article
Microbiology
Yanling Pang, Yiming Yan, Xinheng Zhang, Feng Chen, Qingbin Luo, Qingmei Xie, Wencheng Lin
Summary: In this study, it was found that gga-miR-200b-3p acts as a positive host factor enhancing ALV-J replication by targeting host protein DUSP1. This highlights the crucial role of gga-miR-200b-3p in the replication of ALV-J.
VETERINARY MICROBIOLOGY
(2022)