Article
Multidisciplinary Sciences
Dion Kaiserman, Peishen Zhao, Caitlin Lorraine Rowe, Andrea Leong, Nicholas Barlow, Lars Thomas Joeckel, Corinne Hitchen, Sarah Elizabeth Stewart, Morley D. Hollenberg, Nigel Bunnett, Andreas Suhrbier, Phillip Ian Bird
Summary: GzmK and GzmA can activate PAR1 and PAR2, influencing cell signaling cascades and leading to the release of inflammatory cytokines. This suggests that GzmK acts as a pro-inflammatory regulator during immune responses.
Article
Multidisciplinary Sciences
Dion Kaiserman, Peishen Zhao, Caitlin Lorraine Rowe, Andrea Leong, Nicholas Barlow, Lars Thomas Joeckel, Corinne Hitchen, Sarah Elizabeth Stewart, Morley D. Hollenberg, Nigel Bunnett, Andreas Suhrbier, Phillip Ian Bird
Summary: Granzyme K (GzmK) and GzmA can activate PAR1 and PAR2, and are involved in inflammatory response and cell signaling cascade. Despite cleaving PAR2 at the same point as trypsin, GzmK activates a distinct signaling pathway instead of the classical Ca2+ flux. In epithelial cells, GzmK induces the release of inflammatory cytokines through the activation of PAR2.
Article
Veterinary Sciences
Hector A. Rojas, Brad J. White, David E. Amrine, Robert L. Larson, Sarah F. Capik, Brandon E. Depenbusch
Summary: This study evaluated the potential associations between pen housing conditions and respiratory disease risk in beef feedlot cattle. The number of water sources was found to be associated with lower respiratory disease risk in certain weight and group size conditions.
VETERINARY SCIENCES
(2022)
Article
Veterinary Sciences
Blaine Johnson, Brad White, Phillip Lancaster, Robert Larson
Summary: This study performed cluster analyses on the cohort temporal distributions of bovine respiratory disease (BRD), and identified different temporal patterns that could influence disease prevention and control techniques. Descriptive and statistical associations of risk factors for each cluster better described the cattle represented within each cluster. More research is needed to understand the potential economic impact each cluster has on feedlot production, and improved understanding of cohort timing and magnitude of BRD could potentially identify interventions to mitigate disease burden and economic impacts.
VETERINARY SCIENCES
(2023)
Article
Veterinary Sciences
Deepak, Sharif S. Aly, William J. Love, Patricia C. Blanchard, Beate Crossley, Alison L. Van Eenennaam, Terry W. Lehenbauer
Summary: The study estimated the association of BRD risk factors in pre-weaned dairy calves in California. Female calves were more negatively impacted by failure of passive immunity transfer compared to male calves. Different pathogens had varying odds ratios, with Mannheimia haemolytica and Pasteurella multocida showing high associations with BRD. Age, sex, immune status, and pathogens all played a role in BRD occurrence in pre-weaned dairy calves.
PREVENTIVE VETERINARY MEDICINE
(2021)
Article
Microbiology
Caitlyn A. Cowick, Brynnan P. Russ, Anna R. Bales, Bindu Nanduri, Florencia Meyer
Summary: Bovine Respiratory Disease (BRD) is a global multifactorial condition that causes high rates of illness and death in cattle. This study focused on the interaction between BRD pathogens and found that M. haemolytica negatively affects the replication of BoHV-1 in a dose-dependent manner in different in vitro models.
Article
Immunology
Aiping Ma, Liang Zhang, Xiaokai Ye, Jing Chen, Jie Yu, Liangjin Zhuang, Chaohang Weng, Frank Petersen, Zhanxiang Wang, Xinhua Yu
Summary: The study found a positive association between the duration of illness in patients with severe COVID-19 and serum levels of IL-8 and soluble IL-2R alpha, indicating the involvement of neutrophils and T cells in the evolution of COVID-19.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xiao Liu, Kevin Vanvarenberg, Kobenan Guy Wilfried Kouassi, Sohaib Mahri, Rita Vanbever
Summary: In this study, a PEGylated version of AAT was produced and characterized in vitro, showing potential for prolonged body residence time and improved therapeutic efficacy via intravenous and inhalation routes.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Alina Maria Andronovici, Irina-Draga Caruntu, Mihai Onofriescu, Loredana Liliana Hurjui, Simona-Eliza Giusca, Andreea Simona Covic, Radu Braescu, Liliana-Georgeta Foia
Summary: This study aimed to analyze the relationship between periodontitis and chronic kidney disease (CKD) and provide an inflammatory profile of dialysis patients by measuring the levels of inflammatory biomarkers in periodontitis patients. The results showed significant differences in the levels of these biomarkers between periodontitis patients with CKD and those without CKD, supporting the mutual connection between periodontitis and CKD.
APPLIED SCIENCES-BASEL
(2022)
Article
Agriculture, Dairy & Animal Science
Enrico Fiore, Anastasia Lisuzzo, Andrea Beltrame, Barbara Contiero, Matteo Gianesella, Eliana Schiavon, Rossella Tessari, Massimo Morgante, Elisa Mazzotta
Summary: The study evaluated the feasibility of thoracic ultrasound in detecting respiratory diseases and assessing treatment efficacy. The findings revealed that lung ultrasound is a useful diagnostic tool for screening respiratory diseases. Moreover, tulathromycin and ketoprofen treatment were effective in reducing both clinical symptoms and lung lesions.
Article
Immunology
Samantha Howe, Beth Kegley, Jeremy Powell, Shicheng Chen, Jiangchao Zhao
Summary: This study examined the relationship between bovine respiratory disease (BRD) and respiratory microbiome diversity and composition. The results showed that BRD had an impact on the alpha diversity of the respiratory microbiome and identified specific taxa that were differentially abundant in the nasal cavity. The study also highlighted the importance of considering sampling location and sample processing when comparing results across studies.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Maria Gabriella Matera, Paola Rogliani, Josuel Ora, Luigino Calzetta, Mario Cazzola
Summary: Preclinical research on NE inhibitors has shown promising results, but sivelestat is currently the only approved treatment for ALI/ARDS. Further studies are needed to identify specific patient subsets who may benefit from NE inhibitor treatment and to develop more advanced NE inhibitors.
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2023)
Article
Biochemistry & Molecular Biology
Xiaojie Chu, Zehua Sun, Du-San Baek, Wei Li, John W. Mellors, Steven D. Shapiro, Dimiter S. Dimitrov
Summary: The study identified two high-affinity, specific, and noncompetitive anti-NE antibodies from human libraries, which can effectively inhibit NE enzymatic activity and have potential for antibody-based immunotherapy for cancer and inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Veterinary Sciences
Madison M. Porter, Paiton O. McDonald, Jamison R. Slate, Amanda J. Kreuder, Jodi L. McGill
Summary: Bovine respiratory disease (BRD) is caused by complex interactions between viral and bacterial pathogens, host immune status, and environmental stressors. Current methods for detecting BRD commonly focus on visual indicators and vital signs, while thoracic ultrasonography (TUS) is becoming more important in diagnosis.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Immunology
Marina Luise Viola Azevedo, Aline Cristina Zanchettin, Caroline Busatta Vaz de Paula, Jarbas da Silva Motta Junior, Mineia Alessandra Scaranello Malaquias, Sonia Mara Raboni, Plinio Cezar Neto, Rafaela Chiuco Zeni, Amanda Prokopenko, Nicolas Henrique Borges, Thiago Mateus Godoy, Ana Paula Kubaski Benevides, Daiane Gavlik de Souza, Cristina Pellegrino Baena, Cleber Machado-Souza, Lucia de Noronha
Summary: By comparing post-mortem lung samples from patients who died of severe COVID-19 and H1N1pdm09 infection, it was found that the H1N1 group showed an increase in tissue expression of IL-8/IL-17A and a higher number of neutrophils. There was no significant difference in the distribution of genotype frequencies in the IL17A gene between the two groups. However, in SNP rs3819025 (G/A), the G allele may be considered a risk allele in patients who died from COVID-19.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pathology
J. Wessely-Szponder, J. Michalska, T. Szponder, B. Zylinska, M. Tarczynska, M. Szubstarski
JOURNAL OF COMPARATIVE PATHOLOGY
(2020)
Article
Veterinary Sciences
Joanna Michalska, Beata Nowicka, Joanna Wessely-Szponder
JOURNAL OF EQUINE VETERINARY SCIENCE
(2020)
Article
Microbiology
Joanna Zdziennicka, Tomasz Szponder, Joanna Wessely-Szponder
Summary: The study evaluated the use of neutrophil products to stimulate macrophages and improve healing in animal models. Degranulation products showed pro-inflammatory effects, while microvesicles acted as anti-inflammatory stimulators on macrophages. The response to autologous or heterologous neutrophil extract depended on the origin, regulating macrophage activity into pro-inflammatory or anti-inflammatory phenotypes.
Article
Biochemistry & Molecular Biology
Joanna Zdziennicka, Andrzej Junkuszew, Michal Latalski, Michal Swieca, Joanna Wessely-Szponder
Summary: The study focused on assessing the interaction between neutrophil activity and Titanium implants in biomedical applications. Results showed that under specific treatment conditions, neutrophil activity can significantly increase or decrease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Joanna Wessely-Szponder, Joanna Zdziennicka, Andrzej Junkuszew, Michal Latalski, Michal Swieca, Tomasz Szponder
Summary: This review outlines the functions, clinical applications, and future hopes associated with using autologous or heterologous products obtained from circulating neutrophils in regenerative medicine. It also describes the interactions between neutrophils and platelets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
Joanna Zdziennicka, Joanna Wessely-Szponder, Grzegorz Starobrat, Andrzej Junkuszew
Summary: Titanium is a commonly used biomaterial for orthopedic implants, but it may lead to excessive inflammation. Our study on sheep models found that insertion of Ti implants did not cause adverse effects and had no negative impact on neutrophils and MDM. Antimicrobial neutrophil extract showed anti-inflammatory effects, while neutrophil degranulation product acted as pro-inflammatory.
Review
Medicine, General & Internal
Michal Latalski, Grzegorz Starobrat, Marek Fatyga, Ireneusz Sowa, Magdalena Wojciak, Joanna Wessely-Szponder, Slawomir Dresler, Anna Danielewicz
Summary: This study reviewed the occurrence of wound problems and surgical site infections (SSIs) in early-onset scoliosis (EOS) surgery. The study found a varying but high rate of wound-related problems in EOS surgery. The interpretation of data regarding EOS wound-related complications was often difficult, causing difficulties in comparison and analysis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Tomasz Szponder, Michal Latalski, Anna Danielewicz, Katarzyna Krac, Aleksandra Kozera, Beata Drzewiecka, Dominika Nguyen Ngoc, Dominika Dobko, Joanna Wessely-Szponder
Summary: Osteoarthritis (OA) is a chronic, progressive disease characterized by the loss of articular cartilage in middle-aged and older patients. The immune system plays a pivotal role in the pathogenesis of OA, with both humoral and cellular mediators contributing to cartilage destruction and joint inflammation. Animal models are widely used to study the disease and potential therapies. This review provides an overview of OA signs, pathogenesis, and classification, as well as discussing the advantages and disadvantages of different animal models. Treatment options include mesenchymal stem cells, gene therapies, and blood-derived products, along with tissue engineering techniques and biomaterials.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Paulina Kazimierczak, Joanna Wessely-Szponder, Krzysztof Palka, Adriana Barylyak, Viktor Zinchenko, Agata Przekora
Summary: This study comprehensively compared the biomedical potential of fabricated HAP- and FAP-based bone scaffolds. The results showed that FAP-based biomaterial had higher biodegradability and absorbability, but both materials had similar biocompatibility and osteoconductivity, indicating their promising potential for bone regeneration applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Eric Fernandez-De La Cruz, Joanna Wessely-Szponder, Miguel Vinas, Teresa Vinuesa, Alexandra Merlos, Marta Jorba, Paula Espinal, Ester Fuste
Summary: This study aimed to explore the antimicrobial activity and mechanisms of action of a porcine neutrophil cathelicidin mixture (MPPN). It was found that MPPN exhibited bactericidal activity against E. coli at high concentrations and bacteriostatic activity at lower concentrations. The interaction of MPPN with lipid bilayers caused alterations in the structure.
Article
Chemistry, Physical
Beata Drzewiecka, Agata Przekora, Dominika Dobko, Aleksandra Kozera, Katarzyna Krac, Dominika Nguyen Ngoc, Eric de la Cruz, Joanna Wessely-Szponder
Summary: Implant insertion may cause excessive inflammation and lead to complications. Neutrophils and macrophages play important roles in tissue repair and their responses to biomaterials were examined. Porcine neutrophils exposed to hydroxyapatite (HA) showed increased enzyme release and ROS/RNS generation. Human neutrophils produced more NO after contact with HA, while HAP or FAP did not elicit a significant response. Human macrophages produced more superoxide and NO when cultured with HA, and curdlan reduced ROS/RNS generation. AMPNE reduced neutrophil activity with all biomaterials except curdlan.
Article
Veterinary Sciences
Joanna Wessely-Szponder, Tomasz Szponder, Ryszard Bobowiec, Joanna Michalska
JOURNAL OF VETERINARY RESEARCH
(2019)
Article
Veterinary Sciences
J. Wessely-Szponder, T. Szponder, A. Fijalkowska-Nestorowicz, R. Bobowiec, A. Sobczynska
POLISH JOURNAL OF VETERINARY SCIENCES
(2018)
Article
Medicine, Research & Experimental
Tomasz Szponder, Joanna Wessely-Szponder, Aleksandra Sobczynska-Rak
Article
Medicine, Research & Experimental
Tomasz Szponder, Joanna Wessely-Szponder, Aleksandra Sobczynska-Rak, Beata Zylinska, Radoslaw P. Radzki, Izabella Polkowska