Article
Parasitology
Silvia Goncalves Mesquita, Floria Gabriela dos Santos Neves, Ronaldo Guilherme Carvalho Scholte, Omar dos Santos Carvalho, Cristina Toscano Fonseca, Roberta Lima Caldeira
Summary: This study validated the use of LAMP for detecting Schistosoma mansoni infection in snails of the genus Biomphalaria in Brazil. The results indicated that LAMP was three times as effective as traditional parasitological methods and showed 100% specificity, 85.7% sensitivity, and a kappa index of 0.88.
PARASITES & VECTORS
(2021)
Article
Immunology
Conor E. Fogarty, Phong Phan, Mary G. Duke, Donald P. McManus, Russell C. Wyeth, Scott F. Cummins, Tianfang Wang
Summary: This study identified miracidia attractant candidates using behavioral assays and proteomics, which have the potential to be used as biocontrols for disrupting miracidia infection and reducing schistosomiasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Naphatsamon Uthailak, Poom Adisakwattana, Tipparat Thiangtrongjit, Yanin Limpanont, Phiraphol Chusongsang, Yupa Chusongsang, Kanthi Tanasarnprasert, Onrapak Reamtong
Summary: This study identified serum biomarkers associated with Schistosoma mekongi infection in mice using mass spectrometry-based proteomics. The findings provide potential diagnostic biomarkers for early schistosomiasis diagnosis and vaccine development.
Editorial Material
Parasitology
Yohann Le Govic, Benjamin Gourbal, Jerome Boissier
Summary: Researchers have decoded the functions of genes necessary for worm survival and pathogenesis using postgenomic technologies, paving the way for the development of innovative parasite-targeted therapies in the effort to eliminate schistosomiasis, which is hindered by the incomplete efficacy of the only FDA-approved anti-schistosomal drug, praziquantel.
TRENDS IN PARASITOLOGY
(2021)
Article
Immunology
J. Marquez, N. Dinguirard, A. Gonzalez, A. E. Kane, N. R. Joffe, T. P. Yoshino, M. G. Castillo
Summary: This study identified and characterized TEP transcripts in the snail Biomphalaria glabrata, an intermediate host of the Schistosoma parasite. The expression and response of TEPs to S. mansoni exposure were compared between resistant and susceptible snail strains. Differences in constitutive expression levels and differential responses were observed, suggesting the potential role of TEPs in schistosomiasis transmission control.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Parasitology
Philippe Douchet, Benjamin Gourbal, Eric S. Loker, Olivier Rey
Summary: In a One-Health context, it is urgent to establish the links between environmental degradation, biodiversity loss, and the circulation of pathogens. This review focuses on aquatic environmental factors that interact with Schistosoma species, causing schistosomiasis, and how they influence transmission at the ecosystem scale. The concept of ecosystem competence, which measures the ability of an ecosystem to amplify or mitigate the transmission risk of a given pathogen, is introduced as a promising measure for operationalizing the One-Health concept.
TRENDS IN PARASITOLOGY
(2023)
Article
Ecology
Martina R. Laidemitt, Alyssa M. Gleichsner, Christopher D. Ingram, Steven D. Gay, Elizabeth M. Reinhart, Martin W. Mutuku, Polycup Oraro, Dennis J. Minchella, Gerald M. Mkoji, Eric S. Loker, Michelle L. Steinauer
Summary: Schistosome miracidia have fine-tuning abilities in host selection, but do not always choose hosts that maximize their fitness.
Article
Plant Sciences
Hala A. Abdel Salam, Omaimah A. Maghrabi, Esam S. Al-Malki, Kamal S. Albenasy
Summary: The study evaluated the efficacy of thymol as a plant molluscicide in controlling Biomphalaria alexandrina snails, the vectors for transmitting Schistosoma mansoni infection. Thymol showed significant impacts on the survival rate, egg-laying capacity, and biochemical parameters of the snails, suggesting its promising potential as a safe plant molluscicide for controlling B. alexandrina snails.
JOURNAL OF ESSENTIAL OIL BEARING PLANTS
(2021)
Article
Infectious Diseases
Julien Kincaid-Smith, Eglantine Mathieu-Begne, Cristian Chaparro, Marta Reguera-Gomez, Stephen Mulero, Jean-Francois Allienne, Eve Toulza, Jerome Boissier
Summary: The study found that mate choice is not a reproductive isolating factor between Schistosoma haematobium and S. bovis, and there are few pre-zygotic barriers limiting interbreeding between these two species, except for spatial isolation by the final vertebrate host.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Immunology
Lijun Lu, Lijing Bu, Si-Ming Zhang, Sarah K. Buddenborg, Eric S. Loker
Summary: This study provides a comprehensive overview of the transcriptomics responses of the gastropod Biomphalaria glabrata (Bg) following exposure to the trematode Schistosoma mansoni (Sm). The study identified differences in gene expression between schistosome-susceptible and -resistant Bg strains and revealed distinct response patterns at different time points post-exposure. The findings also highlight shared stress responses and specific gene expression patterns in both resistant and susceptible snails.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Infectious Diseases
Julien Kincaid-Smith, Alan Tracey, Ronaldo de Carvalho Augusto, Ingo Bulla, Nancy Holroyd, Anne Rognon, Olivier Rey, Cristian Chaparro, Ana Oleaga, Santiago Mas-Coma, Jean-Francois Allienne, Christoph Grunau, Matthew Berriman, Jerome Boissier, Eve Toulza
Summary: The article describes the occurrence of schistosomiasis and the genetic admixture of hybrid schistosomes, as well as their compatibility with snail vectors. The results indicate that the hybrid is strongly introgressed genetically, with ancient hybridization events and subsequent backcrosses with the human-specific species. The study also highlights the discrepancy between egg morphology and genetic composition of schistosomes, emphasizing the importance of genetic testing for accurate hybrid identification.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Stepanka Nedvedova, Davide De Stefano, Olivier Walker, Maggy Hologne, Adriana Erica Miele
Summary: Genome sequencing of the human parasite Schistosoma mansoni revealed a gene superfamily called micro-exon gene (meg) that encodes secreted MEG proteins. Through bioinformatics tools and phylogenetic analysis, this study identified conserved patterns in the sequences of highly variable MEG proteins and classified them into two subfamilies. It also proposed revisiting the common names and annotations of MEGs to avoid duplication and misunderstandings.
Article
Microbiology
Amos Mathias Onyekwere, Alejandra De Elias-Escribano, Julien Kincaid-Smith, Sarah Dametto, Jean-Francois Allienne, Anne Rognon, Maria Dolores Bargues, Jerome Boissier
Summary: This experimental study provides new insights into the mating behavior between Schistosoma bovis and S. mansoni in mixed infections in mice. The study shows that the mating between the two species is not random, with S. mansoni exhibiting greater mate recognition. The offspring generated from different mating pairs of the two species can only infect specific mollusks.
Article
Immunology
Datao Lin, Suoyu Xiang, Benjamin Sanogo, Yousheng Liang, Xi Sun, Zhongdao Wu
Summary: This study collected rotifer samples and found that rotifer exposure significantly affected Biomphalaria straminea, promoting mortality, reducing fecundity, affecting juvenile snail development, and lifespan. Rotifers may have a potential molluscicidal effect on intermediate hosts.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Microbiology
Mostafa Y. Morad, Heba El-Sayed, Ahmed A. Elhenawy, Shereen M. Korany, Abeer S. Aloufi, Amina M. Ibrahim
Summary: The myco-synthesized nano-selenium (SeNPs) showed significant molluscicidal, miracidicidal, and cercaricidal properties against Biomphlaria alexandrina snails and Schistosoma mansoni, making it a potential non-toxic route for reducing the spread of schistosomiasis. Furthermore, the SeNPs exhibited antioxidant properties and caused DNA damage.
Article
Public, Environmental & Occupational Health
Stephen A. Spencer, Emmanuel H. Andriamasy, Cortland Linder, James M. StJ Penney, Jemima Henstridge-Blows, Hannah J. Russell, Kate Hyde, Caitlin Sheehy, Isla L. Young, Benedicte Sjoflot, Daniel A. L. Rakotomampianina, Anjara M. Nandimbiniaina, Gina U. Raderalazasoa, Tahiry N. Ranaivoson, Antsa Andrianiaina, Rasolofomanana S. M. Michele, Zafera A. Rohe, Amaya L. Bustinduy, J. Russell Stothard, Sheena M. Cruickshank, Glenn T. Edosoa, Alain M. Rahetilahy
Summary: Schistosomiasis control requires multisectoral approaches including praziquantel treatment, access to safe water, sanitation and hygiene, and health education. Community input can help ensure health education programs are culturally appropriate to effectively direct protective behavior change. This study reports on the development of an education program for Malagasy children, which resulted in significant improvements in their knowledge and practices related to intestinal schistosomiasis. Continued investment in these tailored education programs can promote the future well-being of children through increased participation in control and treatment activities.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Multidisciplinary Sciences
Neil D. Young, Andreas J. Stroehlein, Tao Wang, Pasi K. Korhonen, Margaret Mentink-Kane, J. Russell Stothard, David Rollinson, Robin B. Gasser
Summary: This study reports the genome of the snail Bulinus truncatus, which is an intermediate host for the human blood fluke Schistosoma haematobium. The authors explore protein groups involved in the snail's interaction with the parasite and identify expansions in gene families linked to immune response regulation. Understanding this snail-parasite relationship could inform interventions to interrupt transmission of schistosomiasis.
NATURE COMMUNICATIONS
(2022)
Article
Microbiology
Andreas J. Stroehlein, Pasi K. Korhonen, V. Vern Lee, Stuart A. Ralph, Margaret Mentink-Kane, Hong You, Donald P. McManus, Louis-Albert Tchuem Tchuente, J. Russell Stothard, Parwinder Kaur, Olga Dudchenko, Erez Lieberman Aiden, Bicheng Yang, Huanming Yang, Aidan M. Emery, Bonnie L. Webster, Paul J. Brindley, David Rollinson, Bill C. H. Chang, Robin B. Gasser, Neil D. Young
Summary: Urogenital schistosomiasis, caused by the blood fluke Schistosoma haematobium, affects over 100 million people globally. Research on the genome of S. haematobium reveals important biological and disease traits, which can contribute to improved control of the disease.
Article
Immunology
Daniel McDowell, Lisa Hurt, Narcis B. Kabatereine, John Russell Stothard, Joanne Lello
Summary: Plasmodium-Schistosoma mansonicoinfections are associated with a reduced Plasmodium intensity in preschool-aged children. This relationship, however, is modified by prior infections, host age, and family wealth. Future research should assess whether these interactions impact host health and parasite control efficacy.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Infectious Diseases
Nathan C. Lo, Fernando Schemelzer Moraes Bezerra, Daniel G. Colley, Fiona M. Fleming, Mamoun Homeida, Narcis Kabatereine, Fatma M. Kabole, Charles H. King, Margaret A. Mafe, Nicholas Midzi, Francisca Mutapi, Joseph R. Mwanga, Reda M. R. Ramzy, Fadjar Satrija, J. Russell Stothard, Mamadou Souncalo Traore, Joanne P. Webster, Juerg Utzinger, Xiao-Nong Zhou, Anthony Danso-Appiah, Paolo Eusebi, Eric S. Loker, Charles O. Obonyo, Reginald Quansah, Song Liang, Michel Vaillant, M. Hassan Murad, Paul Hagan, Amadou Garba
Summary: Schistosomiasis, a parasitic disease infecting approximately 250 million people worldwide, has been controlled through preventive chemotherapy programs. However, the recent increase in scientific evidence and the global supply of praziquantel has resulted in the need to update public health guidance. In 2022, the WHO published new guidelines that expand preventive chemotherapy eligibility, lower the prevalence threshold for treatment, and increase the frequency of treatment.
LANCET INFECTIOUS DISEASES
(2022)
Review
Infectious Diseases
Song Liang, Keerati Ponpetch, Yi-Biao Zhou, Jiagang Guo, Berhanu Erko, J. Russell Stothard, M. Hassan Murad, Xiao-Nong Zhou, Fadjar Satrija, Joanne P. Webster, Justin Remais, Jurg Utzinger, Amadou Garba
Summary: This study aimed to summarize available diagnostic techniques for schistosome infections in non-human animals through a systematic review and meta-analysis. The findings suggest that the parasitologic technique FEA-SD and the molecular technique qPCR are the most promising techniques for schistosome diagnosis in non-human animal hosts.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Infectious Diseases
Julius Mulindwa, Joyce Namulondo, Anna Kitibwa, Jacent Nassuuna, Asanya Nyangiri, Magambo Phillip Kimuda, Alex Boobo, Barbara Nerima, Fred Busingye, Rowel Candia, Annet Namukuta, Ronald Ssenyonga, Noah Ukumu, Paul Ajal, Moses Adriko, Harry Noyes, Claudia J. de Dood, Paul L. A. M. Corstjens, Govert J. van Dam, Alison M. Elliott, Enock Matovu
Summary: Understanding the prevalence of schistosomiasis and its impact on child growth and development is crucial for effective control and elimination of the disease. A survey conducted in villages along the Albert-Nile shoreline in North Western Uganda revealed a high prevalence of schistosomiasis among school aged children. The study also found a high incidence of stunting in these children, which was not directly associated with schistosomiasis infection.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Editorial Material
Parasitology
J. R. Stothard, J. T. Ellis
Article
Infectious Diseases
Akinola Stephen Oluwole, Uwem Friday Ekpo, Obiageli Josephine Nebe, Nse Michael Akpan, Solomon Monday Jacob, Uche Veronica Amazigo, John Russell Stothard
INFECTIOUS DISEASES OF POVERTY
(2022)
Article
Infectious Diseases
Nicholas Ngwili, Derrick N. Sentamu, Max Korir, Moses Adriko, Prudence Beinamaryo, Michel M. Dione, Joyce Moriku Kaducu, Alfred Mubangizi, Pauline Ngina Mwinzi, Lian F. Thomas, Matthew A. Dixon
Summary: A mapping study conducted in Uganda revealed high-risk areas for the zoonotic cestode Taenia solium, indicating the need for urgent control efforts to achieve the World Health Organization's milestones.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Biology
Elias Kabbas-Pinango, Moses Arinaitwe, Govert J. J. van Dam, Adriko Moses, Annet Namukuta, Andrina Barungi Nankasi, Nicholas Khayinja Mwima, Fred Besigye, Joaquin M. Prada, Poppy H. L. Lamberton
Summary: Schistosomiasis affects over 240 million people worldwide. Detecting the parasite eggs using Kato-Katz method is specific but not sensitive, while the urine-based POC-CCA test is more sensitive but has specificity issues and interpretation challenges. This study explores the variation in test results and suggests different thresholds for accurate diagnosis and prevalence monitoring.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Infectious Diseases
Eun Seok Kim, Moses Adriko, Wamboko Aidah, Kabarangira Christine Oseku, David Lokure, Kalpana Sabapathy, Emily Webb
Summary: This study aimed to evaluate the efficacy of dual-dose albendazole compared to single-dose albendazole for treating hookworm infection in Mayuge district, Uganda. The results showed that dual-dose albendazole improved the cure rate of hookworm, but co-administration with fatty food did not significantly improve the treatment efficacy.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Article
Parasitology
A. Juhasz, S. E. J. Barlow, H. Williams, B. Johnson, N. Davies Walsh, L. C. Cunningham, S. Jones, E. J. LaCourse, J. R. Stothard
Summary: This study conducted surveillance on snails in Knowsley Safari in the United Kingdom and identified two significant trematode cercariae, Bilharziella polonica from Planorbarius corneus and Trichobilharzia spp. from Ampullacaena balthica. Genetic analysis revealed that the latter likely consisted of two taxa. The study also assessed the swimming rate of B. polonica and evaluated the risk of cercarial dermatitis for public activities.
JOURNAL OF HELMINTHOLOGY
(2022)
Article
Infectious Diseases
Sekeleghe A. Kayuni, Mohammad H. Al-Harbi, Peter Makaula, Boniface Injesi, Bright Mainga, Fanuel Lampiao, Lazarus Juziwelo, E. James LaCourse, J. Russell Stothard
Summary: Pathologies in male genitalia related to male genital schistosomiasis can be detected through ultrasonography, which can describe the morbidity of the disease when there are positive findings in parasitological and molecular tests. The advancements in ultrasonography and its accessibility in endemic areas can help monitor the resolution of pathologies after treatment.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2022)
Article
Infectious Diseases
Mohammad H. Alharbi, Cynthia Iravoga, Sekeleghe A. Kayuni, Lucas Cunningham, E. James LaCourse, Peter Makaula, J. Russell Stothard
Summary: This study reveals the new diversity of Bulinus africanus group snails in Lake Malawi and provides insights into the recent changes in the epidemiology of urogenital schistosomiasis.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2022)
Article
Parasitology
Gabriela Martinez Moura Tavares, Hannar Angelica de Melo Alverga, Estela Moraes Felix, Giovana de Oliveira Dichman, Gabriel Monteiro Pinheiro, Yara Juliano, Priscila Paruci, Dennis Minoru Fujita, Lucas Melo Neves, Marina Tiemi Shio, Luiz Henrique da Silva Nali
Summary: This study investigated the frequency of N. gonorrhoeae infection in women in a poor area of São Paulo and found that most of the strains detected showed resistance to one or more antimicrobials.
Article
Parasitology
Qian Yao, Ying-Ying Fan, Shuang Huang, Gui-Rong Hu, Jun-Ke Song, Xin Yang, Guang-Hui Zhao
Summary: This study found that the expression of miR-4521 was upregulated during C. parvum infection, and this upregulation was related to the TLR/NF-kappa B signal pathway. Additionally, miR-4521 promoted the propagation of C. parvum in HCT-8 cells by regulating BCL2-mediated cell apoptosis through targeting foxm1.
Article
Parasitology
Cho Naing, Maxine A. Whittaker, Wong Siew Tung, Htar Aung, Joon Wah Mak
Summary: This study aimed to estimate the prevalence of zoonotic brugian filariasis in animals and compare it with the prevalence in humans in the same area. The findings suggest that cats, dogs, and leaf-eating monkeys may serve as potential reservoirs for human brugian filariasis.
Review
Parasitology
Raissa Nogueira de Brito, Susan Tanner, Julie Velasquez Runk, Juliana Hoyos
Summary: This study conducted a scoping review to identify major research themes and knowledge gaps in the social science literature on leishmaniases or Chagas disease. The findings showed that research in this field mainly focuses on the sociocultural, economic, historical, and political dimensions of the diseases. Future research should pay more attention to how social institutions and economic factors shape disease education, control measures, healthcare access, and quality of life of affected individuals.
Article
Parasitology
Minghao Zheng, Mengyao Zhang, Hao Li, Shipo Wu, Yuee Zhao, Jinlong Zhang, Yunyue Zhou, Mohamed Boie Jalloh, Kun Zhang, Lina Chen, Zhiqiang Mi, Yong Cui, Lihua Hou
Summary: Rapid and convenient detection of Plasmodium falciparum, the deadliest malaria parasite in Africa, is crucial for malaria eradication efforts in medical resource-limited settings. A CRISPR-based diagnostic method that can detect P. falciparum without nucleic acid extraction was developed and showed high sensitivity and consistency with qPCR test. It can also detect artemisinin-resistant strains and other laboratory-cultured strains. This method has great potential for clinical testing and large-scale community screening in Africa and other regions.
Article
Parasitology
Fabian Correa-Morales, Cassandra Gonzalez-Acosta, David Ibarra-Ojeda, Miguel Moreno-Garcia
Summary: Since 2002, West Nile Virus (WNV) has been reported in 18 states in Mexico. This paper discusses the proposed hypotheses for the absence of WNV outbreaks in Latin America and provides a context-specific explanation for Mexico.
Article
Parasitology
Umberto Molini, Lauren M. Coetzee, Vernon Christians, Maria Y. Hemberger, Bernard Chiwome, Maria Amukwaya, Siegfried Khaiseb, Giovanni Cattoli, William G. Dundon, Giovanni Franzo
Summary: Porcine circovirus 3 (PCV-3) has been reported globally since its first identification in 2015. Limited data on PCV-3 in Africa led to a study in Namibia, which found a high prevalence of PCV-3 in backyard piggeries, but not in commercial farms with higher biosecurity measures. The source of viral introduction and factors such as semen importation, feeding backyard pigs with human food waste, pig exchanges, and wildlife movements may be involved in the dispersal of PCV-3 within Namibia. Further studies are needed to understand the epidemiology and impact of PCV-3 on pig productivity and wildlife health.
Article
Parasitology
Chutchai Piewbang, Panida Poonsin, Pattiya Lohavicharn, Panitnan Punyathi, Sawang Kesdangsakonwut, Tanit Kasantikul, Somporn Techangamsuwan
Summary: This study provides insights into the pathology of natural SARS-CoV-2 infection in dogs, revealing severe damage to the lungs and involvement of multiple organs. The findings suggest the potential utility of dogs as a model for studying SARS-CoV-2 infection in humans, highlighting the need for further investigation.
Article
Parasitology
Julian Avila-Jimenez, Juan David Gutierrez, Mariano Altamiranda-Saavedra
Summary: Leishmaniasis is a parasitic disease transmitted to humans by sandfly vectors and vertebrate hosts. This study used ecological niche modeling to investigate the potential distribution of host and vector species associated with cutaneous leishmaniasis transmission, revealing different distribution patterns under varying climatic conditions.
Article
Parasitology
Luis A. Gomez-Puerta, Juan Olazabal, Santiago Paredes, Juan Lopez, Miguel Anampa, Angelica Mondragon, Ana Vargas-Calla, Hugo Castillo
Summary: This study reports the first detection of Candidatus M. haemolamae infection in vicunas from the Pampa Galeras National Reserve in Peru, using molecular diagnosis. Tick-infested vicunas had a higher likelihood of being infected with Candidatus M. haemolamae compared to tick-free vicunas. Gender and age were not associated with infection.
Article
Parasitology
Berlin Londono-Renteria, Zakaria Seidu, Helena Lamptey, Michael F. Ofori, Lars Hviid, Mary Lopez-Perez
Summary: Heterozygous carriers of HbAS and HbAC have a reduced risk of severe malaria, but not immunity against Plasmodium falciparum infection. Antibody levels against gSG6-P1 peptide in Anopheles mosquito saliva can serve as a serological biomarker for exposure to Plasmodium infection. This study highlights the importance of studying the role of hemoglobinopathies in malaria transmission for improving control interventions.
Article
Parasitology
Imane Belbacha, Meryem El Azzouzi, Rajae Bensghir, Kamal Filali Marhoum, Khadija Hajjout, El Mir Elharti, Khalid Sadki, Hicham Oumzil
Summary: This study investigates the association of three SNPs in the APOBEC3G gene with disease outcomes in Moroccan HIV-1 infected patients. The rs2294367 CG genotype is strongly associated with protection against HIV-1 infection, particularly in older individuals.
Article
Parasitology
Tan Luong, Do Kien Tran, Anh Hung Pham, Thi Thu-Ha Hoang, Van Khang Pham, Quang Thai Pham, Thi Mai Hung Tran, Minh Hoa Luong, Thanh Long Pham, Jason K. Blackburn
Summary: This study examined the epidemiology of anthrax in Lai Chau province, Vietnam, using historical data. Spatial clusters of human and livestock anthrax were identified, and the characteristics of the disease were described. The study found that there were distinct differences between the high-risk areas for human and livestock anthrax, and most human cases occurred during specific seasons. Additionally, the decrease in livestock anthrax vaccine coverage was associated with an increase in disease incidence.
Article
Parasitology
Jin-tao Chen, Jian-bo Zhan, Ming-chao Zhu, Kai-ji Li, Man-qing Liu, Bin Hu, Kun Cai, Hai-rong Xiong, Shu-liang Chen, Wei-long Tan, Liang-jun Chen, Wei Hou
Summary: This study investigated the prevalence and variation of orthohantavirus in rodents and humans in Hubei province, China. It identified the diversity of orthohantaviruses circulating in the region, with the HV004-like subtype being the main genotype in rodents and patients. This highlights the importance of continued attention and research on orthohantaviruses, especially newly identified strains.