Article
Infectious Diseases
Eliezer K. N'Goran, Maurice R. Odiere, Ronald Assande Aka, Mamadou Ouattara, N. A. David Aka, Bernhards Ogutu, Fredrick Rawago, Wilhelmina M. Bagchus, Matthias Boedding, Elly Kourany-Lefoll, Aliona Tappert, Xiaoyan Yin, Deon Bezuidenhout, Henk Badenhorst, Eric Huber, Benjamin Daelken, Okba Haj-Ali Saflo
Summary: This study evaluated the efficacy, safety, palatability, and pharmacokinetics of arpraziquantel tablets for treating schistosomiasis in preschool-aged children. The results showed that arpraziquantel tablets demonstrated good efficacy and safety in the treatment of schistosomiasis in preschool-aged children.
LANCET INFECTIOUS DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Erica Tex Paulino, Monique Ribeiro de Lima, Alessandra Lifsitch Vicosa, Cleber Hooper da Silva, Claudio Javier Salomon, Daniel Andres Real, Dario Leonardi, Clelia Christina Mello Silva, Antonio Henrique Almeida de Moraes Neto
Summary: This study evaluated the effects of two formulations of Praziquantel (PZQ) - PZQ-NANO and PZQ-API - on the prepatent phase of schistosomiasis. The results showed that PZQ-API could reduce the parasite load of infected animals and treatment at 15 days post-infection prevented increased serum levels of ALT, AST, and TP.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Immunology
Justin Komguep Nono, Thabo Mpotje, Paballo Mosala, Nada Abdel Aziz, Fungai Musaigwa, Lerato Hlaka, Thomas Spangenberg, Frank Brombacher
Summary: This study found that treatment of S. mansoni-infected hosts with praziquantel can rewire the immune system to reduce susceptibility to reinfection in mice. While more infection-treatment cycles can enhance the host's ability to resist parasites, it also increases the risk of liver pathology.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Jan Pieter R. Koopman, Emma L. Houlder, Jacqueline J. Janse, Miriam Casacuberta-Partal, Olivia A. C. Lamers, Jeroen C. Sijtsma, Claudia de Dood, Stan T. Hilt, Arifa Ozir-Fazalalikhan, Vincent P. Kuiper, Geert V. T. Roozen, Laura M. de Bes-Roeleveld, Yvonne C. M. Kruize, Linda J. Wammes, Hermelijn H. Smits, Lisette van Lieshout, Govert J. van Dam, Inge M. van Amerongen-Westra, Pauline Meij, Paul L. A. M. Corstjens, Simon P. Jochems, Angela van Diepen, Maria Yazdanbakhsh, Cornelis H. Hokke, Meta Roestenberg
Summary: A single-sex female-only CHI-S model for schistosomiasis was established in this study, providing a tool for vaccine development and understanding early immune responses. The results showed that female-only infections exhibit similar clinical and immunological profiles as male-only infections but are more resistant to treatment with praziquantel.
Article
Parasitology
Ho Yin Pekkle Lam, Po-Ching Cheng, Shih-Yi Peng
Summary: The combination therapy of PZQ and Sch B demonstrates beneficial effects in treating schistosomiasis by improving hepatosplenomegaly, fibrosis, lung and intestinal injuries, and survival rate, while partially improving neurological function.
INTERNATIONAL JOURNAL FOR PARASITOLOGY
(2022)
Article
Infectious Diseases
Hermine Boukeng Jatsa, Ulrich Membe Femoe, Calvine Noumedem Dongmo, Romuald Issiaka Ngassam Kamwa, Betrand Nono Fesuh, Louis-Albert Tchuem Tchuente, Pierre Kamtchouing
Summary: This study investigated the impact of Schistosoma haematobium or S. mansoni infection on the reproductive function of men in Cameroon. The results showed that infection with S. haematobium or S. mansoni is associated with low production of the reproductive hormone testosterone and may be a significant cause of male infertility.
BMC INFECTIOUS DISEASES
(2022)
Article
Parasitology
Etienne K. Angora, Alexane Vangraefschepe, Jean-Francois Allienne, Herve Menan, Jean T. Coulibaly, Aboulaye Meite, Giovanna Raso, Mirko S. Winkler, William Yavo, Andre O. Toure, Eliezer K. N'Goran, Jakob Zinsstag, Jurg Utzinger, Oliver Balmer, Jerome Boissier
Summary: This study investigated the population genetics and genetic structure of Schistosoma haematobium in different parts of Cote d'Ivoire, as well as the frequency of S. haematobium x S. bovis hybrids in school-aged children. The results showed significant differences in genetic diversity between different sites and clustering of parasite genotypes within individual children.
Review
Cell Biology
Verena von Buelow, Jakob Lichtenberger, Christoph G. Grevelding, Franco H. Falcone, Elke Roeb, Martin Roderfeld
Summary: Schistosomiasis is a prominent parasitic infectious disease that causes significant medical and socioeconomic problems, with S. mansoni infection potentially predisposing patients to or promoting cancer development. Further research is needed to fully understand the association between S. mansoni infection and human cancer.
Article
Parasitology
Ho Yin Pekkle Lam, Ting-Hua Yang, Ting-Ruei Liang, Po-Ching Cheng, Kai-Chih Chang, Shih-Yi Peng
Summary: The study investigated whether heat-killed Propionibacterium acnes can serve as a potential adjuvant for recombinant Sm28GST antigen, and found that it successfully modulated the Th1 humoral immune response and induced stronger Th1 cytokine responses. Immunization with P. acnes-adjuvanted rSm28GST reduced worm burden and hepatic egg burden, improved liver histology, and provided more profound protection against S. mansoni-induced liver damages.
Article
Immunology
Nadia Marascio, Maria Teresa Loria, Grazia Pavia, Cinzia Peronace, Neill James Adams, Morena Campolo, Francesca Divenuto, Angelo Giuseppe Lamberti, Aida Giancotti, Giorgio Settimo Barreca, Maria Mazzitelli, Enrico Maria Trecarichi, Carlo Torti, Francesca Perandin, Zeno Bisoffi, Angela Quirino, Giovanni Matera
Summary: The host response to helminth infections is characterized by systemic and tissue-related immune responses. Experimental studies have shown the importance of regulatory T and B cells with secreted cytokines in anti-schistosomiasis immunity. This study investigated the serum levels of five cytokines in samples from Schistosoma-infected patients before and after treatment, and found that IL-35 may serve as a potential serological biomarker for the evaluation of Schistosoma therapy follow-up.
Article
Infectious Diseases
Jean Claude Dejon-Agobe, Ayola A. Adegnika, Martin P. Grobusch
Summary: Schistosomiasis has a significant impact on the full blood counts of school children, leading to changes in all three blood cell lines. The disease is associated with lower levels of hemoglobin and hematocrit, as well as alterations in MCV, MCH, platelet, and leukocyte counts. It is important to consider schistosomiasis when interpreting FBC in endemic areas.
Article
Chemistry, Medicinal
Omary Mashiku Minzi, Rajabu Hussein Mnkugwe, Eliford Ngaimisi, Safari Kinung'hi, Anna Hansson, Anton Pohanka, Appolinary Kamuhabwa, Eleni Aklillu
Summary: The study found that co-administration of dihydroartemisinin-piperaquine significantly increases systemic exposure of praziquantel, which may contribute to the increased effectiveness of praziquantel + dihydroartemisinin-piperaquine combination therapy compared to praziquantel alone in treating schistosomiasis.
Article
Multidisciplinary Sciences
Olimpia Lamberti, Narcis B. Kabatereine, Edridah M. Tukahebwa, Goylette F. Chami
Summary: This study found that factors such as age, distance from the lake, and household clustering can influence the risk of Schistosoma mansoni infection. Particularly, children's infection may be related to their caretakers' infection status.
Article
Immunology
Ho Yin Pekkle Lam, Ting-Ruei Liang, Yi-Chia Lan, Kai-Chih Chang, Po-Ching Cheng, Shih-Yi Peng
Summary: This study found that Casticin can effectively attenuate schistosomiasis-induced liver fibrosis and also has an anthelmintic effect.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2022)
Article
Microbiology
Joseph Kabatende, Lazare Ntirenganya, Michael Mugisha, Abbie Barry, Eugene Ruberanziza, Emile Bienvenu, Ulf Bergman, Eleni Aklillu
Summary: Preventive chemotherapy with single-dose praziquantel is an effective intervention strategy for eliminating schistosomiasis. The study conducted in Rwanda demonstrated that single-dose praziquantel is efficacious against light-to-moderate S. mansoni infection and effectively reduces transmission among school-age children.
Article
Public, Environmental & Occupational Health
David Rollinson, Girija Sankar, Mariana Stephens, Anouk Gouvras, Johannes Waltz, Louis Albert Tchuem Tchuente, Rubina Imtiaz
Summary: The implementation of the new WHO NTD Roadmap (2021-2030) provides an opportunity for single disease alliances and coalitions to integrate and adapt control and elimination programs. This discussion highlights the potential benefits of greater cohesion and innovation in neglected tropical disease-control programs when aiming to achieve elimination goals.
INTERNATIONAL HEALTH
(2022)
Article
Infectious Diseases
Christos Kokaliaris, Amadou Garba, Martin Matuska, Rachel N. Bronzan, Daniel G. Colley, Ameyo M. Dorkenoo, Uwem F. Ekpo, Fiona M. Fleming, Michael D. French, Achille Kabore, Jean B. Mbonigaba, Nicholas Midzi, Pauline N. M. Mwinzi, Eliezer K. N'Goran, Maria Rebollo Polo, Moussa Sacko, Louis-Albert Tchuem Tchuente, Edridah M. Tukahebwa, Pitchouna A. Uvon, Guojing Yang, Lisa Wiesner, Yaobi Zhang, Juerg Utzinger, Penelope Vounatsou
Summary: In sub-Saharan Africa, the prevalence of schistosomiasis among school-aged children decreased from 23.0% in 2000-10 to 9.6% in 2015-19, representing an overall reduction of 58.3%. The substantial decrease in prevalence is likely attributed to the scale-up of preventive chemotherapy interventions. It is necessary to maintain the progress in schistosomiasis control through various interventions, including preventive chemotherapy.
LANCET INFECTIOUS DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Roy N. Platt, Winka Le Clec'h, Frederic D. Chevalier, Marina McDew-White, Philip T. LoVerde, Rafael Ramiro de Assis, Guilherme Oliveira, Safari Kinung'hi, Amadou Garba Djirmay, Michelle L. Steinauer, Anouk Gouvras, Muriel Rabone, Fiona Allan, Bonnie L. Webster, Joanne P. Webster, Aidan M. Emery, David Rollinson, Timothy J. C. Anderson
Summary: The blood fluke parasite, Schistosoma mansoni, was introduced into the Americas from Africa during the Trans-Atlantic slave trade. Research shows that the parasite successfully adapted to the snail intermediate host in South America, without facing significant population bottlenecks or barriers to colonization. Furthermore, genetic analysis indicates differences in gene selection between the Americas and Africa, suggesting adaptation during colonization.
Article
Parasitology
Jerzy M. Behnke, Alex Stewart, Lesley Smales, Gemma Cooper, Ann Lowe, John M. Kinsella, Anna Bajer, Dorota Dwuznik-Szarek, Jeremy Herman, Jonathan Fenn, Stefano Catalano, Christophe A. Diagne, Joanne P. Webster
Summary: The study examined Oxyurid nematodes from bank and field voles in the British Isles, providing genetic signatures of new isolates and confirming S. nigeriana as a parasite of both bank and field voles. Additionally, related Syphacia species were found in Mastomys spp. from West Africa, indicating a wide distribution of parasitic nematodes among rodent genera.
Review
Infectious Diseases
Nathan C. Lo, Fernando Schemelzer Moraes Bezerra, Daniel G. Colley, Fiona M. Fleming, Mamoun Homeida, Narcis Kabatereine, Fatma M. Kabole, Charles H. King, Margaret A. Mafe, Nicholas Midzi, Francisca Mutapi, Joseph R. Mwanga, Reda M. R. Ramzy, Fadjar Satrija, J. Russell Stothard, Mamadou Souncalo Traore, Joanne P. Webster, Juerg Utzinger, Xiao-Nong Zhou, Anthony Danso-Appiah, Paolo Eusebi, Eric S. Loker, Charles O. Obonyo, Reginald Quansah, Song Liang, Michel Vaillant, M. Hassan Murad, Paul Hagan, Amadou Garba
Summary: Schistosomiasis, a parasitic disease infecting approximately 250 million people worldwide, has been controlled through preventive chemotherapy programs. However, the recent increase in scientific evidence and the global supply of praziquantel has resulted in the need to update public health guidance. In 2022, the WHO published new guidelines that expand preventive chemotherapy eligibility, lower the prevalence threshold for treatment, and increase the frequency of treatment.
LANCET INFECTIOUS DISEASES
(2022)
Review
Parasitology
E. Raj, B. Calvo-Urbano, C. Heffernan, J. Halder, J. P. Webster
Summary: Despite the significant mortality and morbidity caused by helminth infections, the current evidence does not support the hypothesis that helminths directly cause physical stunting in children. However, there is significant heterogeneity between studies, and data from key demographic groups are lacking.
PARASITES & VECTORS
(2022)
Article
Parasitology
Praise Adeyemo, Elsa Leger, Elizabeth Hollenberg, Nicolas Diouf, Mariama Sene, Joanne P. Webster, Barbara Hasler
Summary: This study aimed to estimate the financial impact of livestock schistosomiasis in selected regions of Senegal. The findings suggest that the financial impact of livestock schistosomiasis on traditional subsistence and transhumance farmers is substantial, and treating the disease has the potential to generate considerable benefits to farmers and their families.
PARASITES & VECTORS
(2022)
Article
Public, Environmental & Occupational Health
Klodeta Kura, James E. Truscott, Benjamin S. Collyer, Anna Phillips, Amadou Garba, Roy M. Anderson
Summary: The study found that soil-transmitted helminths and schistosome parasites are highly aggregated within the human population. Statistical methods were used to estimate the aggregation parameter k using two large independent datasets. The results of the study suggest that greater attention needs to be given to identifying and treating remaining aggregates of parasites.
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
(2022)
Review
Infectious Diseases
Song Liang, Keerati Ponpetch, Yi-Biao Zhou, Jiagang Guo, Berhanu Erko, J. Russell Stothard, M. Hassan Murad, Xiao-Nong Zhou, Fadjar Satrija, Joanne P. Webster, Justin Remais, Jurg Utzinger, Amadou Garba
Summary: This study aimed to summarize available diagnostic techniques for schistosome infections in non-human animals through a systematic review and meta-analysis. The findings suggest that the parasitologic technique FEA-SD and the molecular technique qPCR are the most promising techniques for schistosome diagnosis in non-human animal hosts.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Microbiology
Kirsty J. Marsh, Aura M. Raulo, Marc Brouard, Tanya Troitsky, Holly M. English, Bryony Allen, Rohan Raval, Saudamini Venkatesan, Amy B. Pedersen, Joanne P. Webster, Sarah C. L. Knowles
Summary: The gut microbiome plays important roles in mammalian hosts, with the community composition shaping its functions. Factors driving individual microbiota variation in wild animals and how predictable or idiosyncratic they are remain poorly understood. This study on wood mice revealed consistent patterns of seasonal gut microbiota restructuring across different populations, despite involving different taxa, highlighting the importance of future research on the drivers and implications of such seasonal microbiome dynamics.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Infectious Diseases
Antonio Montresor, Pauline Mwinzi, Denise Mupfasoni, Amadou Garba
Summary: Preventive chemotherapy interventions for soil-transmitted helminthiases and schistosomiasis have significantly reduced the number of disability-adjusted life years lost in the past 19 years. Deworming is considered one of the most cost-effective public health interventions due to its low cost and high impact.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Review
Parasitology
Gregory Colin Milne, Joanne P. Webster, Martin Walker
Summary: Several studies have suggested a decline in the incidence of congenital toxoplasmosis due to decreasing seroprevalence of Toxoplasma gondii. However, the consistency of this trend across different populations and its implications for prenatal screening programs remain unclear. This study explores how the changing epidemiology of the parasite may affect trends in congenital toxoplasmosis incidence and emphasizes the importance of updating cost-effectiveness estimates of screening programs to account for neuropsychiatric sequelae.
TRENDS IN PARASITOLOGY
(2023)
Review
Parasitology
Isobel L. Gabain, Anouschka S. Ramsteijn, Joanne P. Webster
Summary: Globally, approximately 149.2 million children under the age of 5 are affected by stunting, but the underlying causes and mechanisms are still unclear, leading to limited treatment and prevention strategies. The direct link between parasites and stunting is often lacking due to the complex nature of stunting and a lack of interdisciplinary research. Based on existing studies, this paper presents potential pathways by which parasitic infection in mothers and/or infants may lead to childhood stunting. The need for future multidisciplinary longitudinal studies and clinical trials to identify influential factors and develop effective solutions is highlighted.
TRENDS IN PARASITOLOGY
(2023)
Review
Infectious Diseases
Takalani Girly Nemungadi, Tsakani Ernica Furumele, Mary Kay Gugerty, Amadou Garba Djirmay, Saloshni Naidoo, Eyrun Florecke Kjetland
Summary: Female genital schistosomiasis is a complication of Schistosoma haematobium infection, with over 56 million affected women in sub-Saharan Africa. Without treatment for infected girls, there will be an additional 20 million cases in the next decade. South Africa lacks a formal control program for the disease.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2022)
Article
Parasitology
Gabriela Martinez Moura Tavares, Hannar Angelica de Melo Alverga, Estela Moraes Felix, Giovana de Oliveira Dichman, Gabriel Monteiro Pinheiro, Yara Juliano, Priscila Paruci, Dennis Minoru Fujita, Lucas Melo Neves, Marina Tiemi Shio, Luiz Henrique da Silva Nali
Summary: This study investigated the frequency of N. gonorrhoeae infection in women in a poor area of São Paulo and found that most of the strains detected showed resistance to one or more antimicrobials.
Article
Parasitology
Qian Yao, Ying-Ying Fan, Shuang Huang, Gui-Rong Hu, Jun-Ke Song, Xin Yang, Guang-Hui Zhao
Summary: This study found that the expression of miR-4521 was upregulated during C. parvum infection, and this upregulation was related to the TLR/NF-kappa B signal pathway. Additionally, miR-4521 promoted the propagation of C. parvum in HCT-8 cells by regulating BCL2-mediated cell apoptosis through targeting foxm1.
Article
Parasitology
Cho Naing, Maxine A. Whittaker, Wong Siew Tung, Htar Aung, Joon Wah Mak
Summary: This study aimed to estimate the prevalence of zoonotic brugian filariasis in animals and compare it with the prevalence in humans in the same area. The findings suggest that cats, dogs, and leaf-eating monkeys may serve as potential reservoirs for human brugian filariasis.
Review
Parasitology
Raissa Nogueira de Brito, Susan Tanner, Julie Velasquez Runk, Juliana Hoyos
Summary: This study conducted a scoping review to identify major research themes and knowledge gaps in the social science literature on leishmaniases or Chagas disease. The findings showed that research in this field mainly focuses on the sociocultural, economic, historical, and political dimensions of the diseases. Future research should pay more attention to how social institutions and economic factors shape disease education, control measures, healthcare access, and quality of life of affected individuals.
Article
Parasitology
Minghao Zheng, Mengyao Zhang, Hao Li, Shipo Wu, Yuee Zhao, Jinlong Zhang, Yunyue Zhou, Mohamed Boie Jalloh, Kun Zhang, Lina Chen, Zhiqiang Mi, Yong Cui, Lihua Hou
Summary: Rapid and convenient detection of Plasmodium falciparum, the deadliest malaria parasite in Africa, is crucial for malaria eradication efforts in medical resource-limited settings. A CRISPR-based diagnostic method that can detect P. falciparum without nucleic acid extraction was developed and showed high sensitivity and consistency with qPCR test. It can also detect artemisinin-resistant strains and other laboratory-cultured strains. This method has great potential for clinical testing and large-scale community screening in Africa and other regions.
Article
Parasitology
Fabian Correa-Morales, Cassandra Gonzalez-Acosta, David Ibarra-Ojeda, Miguel Moreno-Garcia
Summary: Since 2002, West Nile Virus (WNV) has been reported in 18 states in Mexico. This paper discusses the proposed hypotheses for the absence of WNV outbreaks in Latin America and provides a context-specific explanation for Mexico.
Article
Parasitology
Umberto Molini, Lauren M. Coetzee, Vernon Christians, Maria Y. Hemberger, Bernard Chiwome, Maria Amukwaya, Siegfried Khaiseb, Giovanni Cattoli, William G. Dundon, Giovanni Franzo
Summary: Porcine circovirus 3 (PCV-3) has been reported globally since its first identification in 2015. Limited data on PCV-3 in Africa led to a study in Namibia, which found a high prevalence of PCV-3 in backyard piggeries, but not in commercial farms with higher biosecurity measures. The source of viral introduction and factors such as semen importation, feeding backyard pigs with human food waste, pig exchanges, and wildlife movements may be involved in the dispersal of PCV-3 within Namibia. Further studies are needed to understand the epidemiology and impact of PCV-3 on pig productivity and wildlife health.
Article
Parasitology
Chutchai Piewbang, Panida Poonsin, Pattiya Lohavicharn, Panitnan Punyathi, Sawang Kesdangsakonwut, Tanit Kasantikul, Somporn Techangamsuwan
Summary: This study provides insights into the pathology of natural SARS-CoV-2 infection in dogs, revealing severe damage to the lungs and involvement of multiple organs. The findings suggest the potential utility of dogs as a model for studying SARS-CoV-2 infection in humans, highlighting the need for further investigation.
Article
Parasitology
Julian Avila-Jimenez, Juan David Gutierrez, Mariano Altamiranda-Saavedra
Summary: Leishmaniasis is a parasitic disease transmitted to humans by sandfly vectors and vertebrate hosts. This study used ecological niche modeling to investigate the potential distribution of host and vector species associated with cutaneous leishmaniasis transmission, revealing different distribution patterns under varying climatic conditions.
Article
Parasitology
Luis A. Gomez-Puerta, Juan Olazabal, Santiago Paredes, Juan Lopez, Miguel Anampa, Angelica Mondragon, Ana Vargas-Calla, Hugo Castillo
Summary: This study reports the first detection of Candidatus M. haemolamae infection in vicunas from the Pampa Galeras National Reserve in Peru, using molecular diagnosis. Tick-infested vicunas had a higher likelihood of being infected with Candidatus M. haemolamae compared to tick-free vicunas. Gender and age were not associated with infection.
Article
Parasitology
Berlin Londono-Renteria, Zakaria Seidu, Helena Lamptey, Michael F. Ofori, Lars Hviid, Mary Lopez-Perez
Summary: Heterozygous carriers of HbAS and HbAC have a reduced risk of severe malaria, but not immunity against Plasmodium falciparum infection. Antibody levels against gSG6-P1 peptide in Anopheles mosquito saliva can serve as a serological biomarker for exposure to Plasmodium infection. This study highlights the importance of studying the role of hemoglobinopathies in malaria transmission for improving control interventions.
Article
Parasitology
Imane Belbacha, Meryem El Azzouzi, Rajae Bensghir, Kamal Filali Marhoum, Khadija Hajjout, El Mir Elharti, Khalid Sadki, Hicham Oumzil
Summary: This study investigates the association of three SNPs in the APOBEC3G gene with disease outcomes in Moroccan HIV-1 infected patients. The rs2294367 CG genotype is strongly associated with protection against HIV-1 infection, particularly in older individuals.
Article
Parasitology
Tan Luong, Do Kien Tran, Anh Hung Pham, Thi Thu-Ha Hoang, Van Khang Pham, Quang Thai Pham, Thi Mai Hung Tran, Minh Hoa Luong, Thanh Long Pham, Jason K. Blackburn
Summary: This study examined the epidemiology of anthrax in Lai Chau province, Vietnam, using historical data. Spatial clusters of human and livestock anthrax were identified, and the characteristics of the disease were described. The study found that there were distinct differences between the high-risk areas for human and livestock anthrax, and most human cases occurred during specific seasons. Additionally, the decrease in livestock anthrax vaccine coverage was associated with an increase in disease incidence.
Article
Parasitology
Jin-tao Chen, Jian-bo Zhan, Ming-chao Zhu, Kai-ji Li, Man-qing Liu, Bin Hu, Kun Cai, Hai-rong Xiong, Shu-liang Chen, Wei-long Tan, Liang-jun Chen, Wei Hou
Summary: This study investigated the prevalence and variation of orthohantavirus in rodents and humans in Hubei province, China. It identified the diversity of orthohantaviruses circulating in the region, with the HV004-like subtype being the main genotype in rodents and patients. This highlights the importance of continued attention and research on orthohantaviruses, especially newly identified strains.