Review
Biochemistry & Molecular Biology
Pei-Feng Liu, Yung-Fu Chang
Summary: This review article highlights the traditional uses of Areca nut (AN) in herbal medicine and social activities, as well as its toxicological effects. The dual effects of AN, with both pharmacological and toxicological effects, are summarized. Perspectives and challenges in removing or modifying toxic compounds in AN extractions for future therapeutic applications are discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Shuhan Yi, Keyu Chen, Kozue Sakao, Makoto Ikenaga, Yuanliang Wang, De-Xing Hou
Summary: The study found that areca nut polyphenols, rich in antioxidants, can alleviate dyslipidemia caused by a Western diet by increasing the abundance of beneficial gut bacteria and reducing the expressions of SREBP2 and HMGCR.
Article
Food Science & Technology
Shuhan Yi, Luyan Zou, Zongjun Li, Kozue Sakao, Yuanliang Wang, De-Xing Hou
Summary: This study demonstrated that polyphenols from areca nuts exhibit antioxidant activity by inhibiting the MAPK pathway and activating the Nrf2/HO-1 antioxidant pathways, leading to a reduction in ROS generation induced by LPS.
Article
Chemistry, Applied
Erpeng Chao, Liuping Fan
Summary: An environmentally friendly physical processing method, hydrothermal treatment (HT), was used to increase the content of specific compounds and antioxidant activities of seed-used pumpkin byproducts. The results showed that HT significantly improved the free polyphenol content and antioxidant activities. A back propagation artificial neural network model was developed to accurately predict the changes in polyphenolic content, which exhibited good fitting and approximation ability as well as stability.
Review
Public, Environmental & Occupational Health
Ruchika Gupta, Suzanne T. Nethan, Dhirendra N. Sinha, Sanjay Gupta, Shalini Singh
Summary: This systematic review summarizes the drivers and interventions for cessation of areca nut chewing habit. The review highlights the barriers to quitting, such as socio-cultural factors, addictive nature of areca nut, and withdrawal symptoms. However, it also identifies factors that increase the likelihood of cessation, such as awareness of the harmful effects of areca nut use. Most studies utilize behavioral interventions for cessation.
JOURNAL OF PUBLIC HEALTH
(2023)
Article
Engineering, Environmental
Ragavendra Rao Pasupuleti, Chien-Hung Lee, Peter G. Osborne, Ming-Tsang Wu, Vinoth Kumar Ponnusamy
Summary: This study presents a green analytical methodology for simultaneous biomonitoring of five toxic areca nut alkaloids in saliva and urine of betel quid chewers. The method demonstrated successful identification and real-time monitoring of these alkaloids, showcasing its utility as an efficient analytical protocol for routine biomonitoring of levels of toxic alkaloids and predicting exposure levels and associated health risks.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Construction & Building Technology
Md Jihad Miah, Ye Li, Suvash Chandra Paul, Adewumi John Babafemi, Jeong Gook Jang
Summary: Cement-based materials have poor tension performance, but adding Areca nut husk fiber (AHF) can enhance mechanical strength and reduce shrinkage. The study investigated the effect of different AHF proportions on mortar properties and found that 0.5% AHF showed the best performance. This research provides important insights for the sustainable use of AHF in cement-based materials.
CONSTRUCTION AND BUILDING MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Rana B. Bakhaidar, Khaled M. Hosny, Imman M. Mahier, Waleed Y. Rizq, Awaji Y. Safhi, Deena M. Bukhary, Muhammad H. Sultan, Haitham A. Bukhary, Osama A. Madkhali, Fahad Y. Sabei
Summary: Using experimental design, tamsulosin, saw palmetto oil, and pumpkin seed oil were combined in a nanostructured lipid carrier to enhance the permeation and therapeutic activity of tamsulosin. The optimized formulation showed improved drug release profile and pharmacokinetic profile, and demonstrated favorable therapeutic efficacy in treating benign prostatic hyperplasia.
Article
Biochemical Research Methods
Adrian A. Franke, Xingnan Li, Thaddeus A. Herzog, Yvette C. Paulino, Grazyna Badowski, Lynne R. Wilkens, Jennifer F. Lai
Summary: The study analyzed saliva biomarker levels to verify the effectiveness of an intervention trial for quitting chewing betel nut. The results showed that saliva biomarker levels aligned with self-reported chewing status, suggesting that they can be used to objectively evaluate compliance and program effectiveness.
DRUG TESTING AND ANALYSIS
(2023)
Review
Cell Biology
Liping Wang, Zhangui Tang
Summary: Oral submucous fibrosis (OSF) is a chronic, progressive, scarring, premalignant disease of the oral mucosa, with complex pathogenic factors including areca nut chewing, nutrition, genetics, and immune factors. Immune factors have recently become the focus of medical research on OSF, with attention on how they play a role in the disease's pathogenesis and treatment. OSF is characterized by significant changes in the immune microenvironment, prompting studies on the role of immune cells and substances in the disease.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Nutrition & Dietetics
Chen-Yuan Hsu, Pei-Chi Chang, Sheng-Lei Yan
Summary: This study examined the correlations among areca nut self-awareness, areca nut cessation self-confidence, and areca nut dependence in the Taiwanese population. The results showed a significant negative correlation between areca nut cessation self-confidence and areca nut dependence. However, there was no significant correlation between areca nut self-awareness and areca nut cessation self-confidence or areca nut dependence. Areca nut self-awareness was significantly correlated with age, occupation, and family support.
FRONTIERS IN NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Lihui Chen, Fulai Yuan, Sifang Chen, Xiong Li, Lingyu Kong, Wei Zhang
Summary: This review summarizes the potential reasons for the disturbance of host microbiota caused by areca nut chewing and clarifies the complex interaction between human microbiome, major constituents, and the addiction and carcinogenicity of areca nut.
Article
Environmental Sciences
Nihal Gujre, Sudip Mitra, Richa Agnihotri, Mahaveer P. Sharma, Debaditya Gupta
Summary: The pyrolytic conversion of locally available agricultural residue, areca nut husk, into biochar has shown promising effects on soil quality improvement. The biochar produced at 250 degrees C with 60 min residence time exhibited the highest soil organic matter yield index and significant benefits for soil enhancement when applied in conjunction with vetiver.
Review
Toxicology
Nuno G. Oliveira, Daniela L. Ramos, Ricardo Jorge Dinis-Oliveira
Summary: Areca nut is consumed by over 600 million individuals and classified as carcinogenic to humans, particularly in South Asia, East Africa, and tropical Pacific regions. Arecoline is the principal active compound of Areca nut and has been systematically studied in several in vitro and in vivo genotoxicity endpoints. The complexity of the chemicals involved in Areca nut makes it a challenge in genetic toxicology, with both positive and negative genotoxicity findings reported in the literature.
ARCHIVES OF TOXICOLOGY
(2021)
Review
Materials Science, Textiles
Georgy Sunny, T. Palani Rajan
Summary: Natural fibers, such as areca nut fibers, are essential in composite and textile industries due to their renewable, biodegradable, and eco-friendly properties. This review provides a comprehensive analysis of the characteristics, extraction methods, and production applications of areca nut fibers, highlighting their advantages over conventional synthetic fibers.
JOURNAL OF NATURAL FIBERS
(2022)
Article
Biodiversity Conservation
Virgile Baudrot, Javier Fernandez-de-Simon, Michael Coeurdassier, Geoffroy Couval, Patrick Giraudoux, Xavier Lambin
JOURNAL OF APPLIED ECOLOGY
(2020)
Article
Entomology
Jens Jacob, Christian Imholt, Constantino Caminero-Saldana, Geoffroy Couval, Patrick Giraudoux, Silvia Herrero-Cofreces, Gyozo Horvath, Juan Jose Luque-Larena, Emil Tkadlec, Eddy Wymenga
JOURNAL OF PEST SCIENCE
(2020)
Article
Multidisciplinary Sciences
Pierre Galanaud, Anne Galanaud, Patrick Giraudoux, Henri Labesse
Article
Ecology
Corentin Nicod, Geoffroy Couval, Patrick Giraudoux, Francois Gillet
ACTA OECOLOGICA-INTERNATIONAL JOURNAL OF ECOLOGY
(2020)
Article
Multidisciplinary Sciences
Petra Villette, Eve Afonso, Geoffroy Couval, Aurelien Levret, Maxime Galan, Anne-Claude Goydadin, Jean-Francois Cosson, Patrick Giraudoux
SCIENTIFIC REPORTS
(2020)
Article
Infectious Diseases
Doudou Batumbo Boloweti, Patrick Giraudoux, Catherine Deniel, Emmanuel Garnier, Frederic Mauny, Celestin Mahinda Kasereka, Roger Kizungu, Jean Jacques Muyembe, Didier Bompangue, Gudrun Bornette
PLOS NEGLECTED TROPICAL DISEASES
(2020)
Article
Ecology
Patrick Giraudoux, Aurelien Levret, Eve Afonso, Michael Coeurdassier, Geoffroy Couval
ECOLOGY AND EVOLUTION
(2020)
Article
Ecology
Wajdi Zaatour, Nicolas Marilleau, Patrick Giraudoux, Nadege Martiny, Abdesslem Ben Haj Amara, Slimane Ben Miled
Summary: This study investigates the spread of zoonotic cutaneous leishmaniasis (ZCL) in Central Tunisia using an agent-based model (ABM) focusing on the movement of Meriones shawi (M.shawi). The research shows that the prevalence of the disease is closely related to rodent movement types and vegetation cover.
ECOLOGICAL MODELLING
(2021)
Article
Parasitology
Qian Wang, Bo Zhong, Wenjie Yu, Guangjia Zhang, Christine M. Budke, Sha Liao, Wei He, Fan Chen, Kejun Xu, Fei Xie, Danbazeli, Qi Wang, Liu Yang, Yan Huang, Ruirui Li, Renxing Yao, Patrick Giraudoux, Philip S. Craig
Summary: Assessment of a control programme in Gansu province showed that deworming owned dogs can significantly reduce E. multilocularis infection in owned dogs and human AE prevalence, but did not have a significant impact on infection in wildlife intermediate hosts.
INTERNATIONAL JOURNAL FOR PARASITOLOGY
(2021)
Article
Infectious Diseases
Sophie Molia, Juliette Saillard, Koussai Dellagi, Florence Cliquet, Jean-Mathieu Bart, Brice Rotureau, Patrick Giraudoux, Jean Jannin, Patrice Debre, Philippe Solano
Summary: The survey results show that One Health approaches are highly attractive to scientists in French-speaking tropical countries, but implementation is challenging due to various factors. Improvements in prevalence and economic data research, along with demonstrating the added value of One Health approaches, are key to increasing uptake. NTD networks play a crucial role in breaking down barriers and promoting collaboration among different sectors and disciplines.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Biodiversity Conservation
Eve Afonso, Rong Fu, Amael Dupaix, Anne-Claude Goydadin, ZhongHua Yu, Dayong Li, Patrick Giraudoux, Li Li
Summary: The development of ecotourism may lead to subpopulations of wildlife becoming genetically structured and experiencing reduced genetic diversity, highlighting the need to strike a balance between conservation and tourism.
GLOBAL ECOLOGY AND CONSERVATION
(2021)
Article
Environmental Sciences
Shinji Ozaki, Clementine Fritsch, Frederic Mora, Thierry Cornier, Renaud Scheifler, Francis Raoul
Summary: This study found that under trace metal contamination, vegetation has a more significant impact on invertebrate communities than the direct effects of trace metals.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Ecology
Monica E. Riojas-Lopez, Eric Mellink, Patrick Giraudoux
Summary: This study investigates the factors influencing bird and rodent assemblages in semi-arid rangelands in the southern Mexican Plateau. The results show that the condition of the rangelands and the seasons have different effects on the abundance and distribution of bird and rodent species. Shrub and nopal habitats are important components influencing the abundance of birds and rodents. Bird species turnover is higher than rodent species turnover, suggesting that birds have greater mobility to explore different patches of rangelands.
RANGELAND ECOLOGY & MANAGEMENT
(2022)
Article
Environmental Sciences
Christopher Marston, Clare Rowland, Aneurin O'Neil, Seth Irish, Francis Wat'senga, Pilar Martin-Gallego, Paul Aplin, Patrick Giraudoux, Clare Strode
Summary: Methods were developed to identify the biogeographical variables driving the abundance and distribution of three malaria vectors in the Democratic Republic of the Congo using Earth Observation (EO) data, mosquito monitoring captures, and Google Earth Engine. The results showed the importance of rainfall and land surface temperature in relation to mosquito abundance, as well as the coverage of forest and grassland. The developed method can provide a crucial tool for designing control programs and improving disease control activities to reduce malaria transmission.
Article
Multidisciplinary Sciences
Christopher Marston, Francis Raoul, Clare Rowland, Jean-Pierre Quere, Xiaohui Feng, Renyong Lin, Patrick Giraudoux
Summary: Small mammal species play a crucial role in various ecological processes and can have significant impacts on agricultural sectors and disease transmission. This study utilizes Earth observation data and on-site surveys to develop species distribution models for nine small mammal species in China and Kyrgyzstan. The models identify the key landscape variables driving species abundance and distributions, highlighting the optimal conditions for each species. The results improve our understanding of small mammal distributions and abundances, bridging the gap between human-defined and species-defined perspectives of optimal habitat.
Article
Parasitology
Gabriela Martinez Moura Tavares, Hannar Angelica de Melo Alverga, Estela Moraes Felix, Giovana de Oliveira Dichman, Gabriel Monteiro Pinheiro, Yara Juliano, Priscila Paruci, Dennis Minoru Fujita, Lucas Melo Neves, Marina Tiemi Shio, Luiz Henrique da Silva Nali
Summary: This study investigated the frequency of N. gonorrhoeae infection in women in a poor area of São Paulo and found that most of the strains detected showed resistance to one or more antimicrobials.
Article
Parasitology
Qian Yao, Ying-Ying Fan, Shuang Huang, Gui-Rong Hu, Jun-Ke Song, Xin Yang, Guang-Hui Zhao
Summary: This study found that the expression of miR-4521 was upregulated during C. parvum infection, and this upregulation was related to the TLR/NF-kappa B signal pathway. Additionally, miR-4521 promoted the propagation of C. parvum in HCT-8 cells by regulating BCL2-mediated cell apoptosis through targeting foxm1.
Article
Parasitology
Cho Naing, Maxine A. Whittaker, Wong Siew Tung, Htar Aung, Joon Wah Mak
Summary: This study aimed to estimate the prevalence of zoonotic brugian filariasis in animals and compare it with the prevalence in humans in the same area. The findings suggest that cats, dogs, and leaf-eating monkeys may serve as potential reservoirs for human brugian filariasis.
Review
Parasitology
Raissa Nogueira de Brito, Susan Tanner, Julie Velasquez Runk, Juliana Hoyos
Summary: This study conducted a scoping review to identify major research themes and knowledge gaps in the social science literature on leishmaniases or Chagas disease. The findings showed that research in this field mainly focuses on the sociocultural, economic, historical, and political dimensions of the diseases. Future research should pay more attention to how social institutions and economic factors shape disease education, control measures, healthcare access, and quality of life of affected individuals.
Article
Parasitology
Minghao Zheng, Mengyao Zhang, Hao Li, Shipo Wu, Yuee Zhao, Jinlong Zhang, Yunyue Zhou, Mohamed Boie Jalloh, Kun Zhang, Lina Chen, Zhiqiang Mi, Yong Cui, Lihua Hou
Summary: Rapid and convenient detection of Plasmodium falciparum, the deadliest malaria parasite in Africa, is crucial for malaria eradication efforts in medical resource-limited settings. A CRISPR-based diagnostic method that can detect P. falciparum without nucleic acid extraction was developed and showed high sensitivity and consistency with qPCR test. It can also detect artemisinin-resistant strains and other laboratory-cultured strains. This method has great potential for clinical testing and large-scale community screening in Africa and other regions.
Article
Parasitology
Fabian Correa-Morales, Cassandra Gonzalez-Acosta, David Ibarra-Ojeda, Miguel Moreno-Garcia
Summary: Since 2002, West Nile Virus (WNV) has been reported in 18 states in Mexico. This paper discusses the proposed hypotheses for the absence of WNV outbreaks in Latin America and provides a context-specific explanation for Mexico.
Article
Parasitology
Umberto Molini, Lauren M. Coetzee, Vernon Christians, Maria Y. Hemberger, Bernard Chiwome, Maria Amukwaya, Siegfried Khaiseb, Giovanni Cattoli, William G. Dundon, Giovanni Franzo
Summary: Porcine circovirus 3 (PCV-3) has been reported globally since its first identification in 2015. Limited data on PCV-3 in Africa led to a study in Namibia, which found a high prevalence of PCV-3 in backyard piggeries, but not in commercial farms with higher biosecurity measures. The source of viral introduction and factors such as semen importation, feeding backyard pigs with human food waste, pig exchanges, and wildlife movements may be involved in the dispersal of PCV-3 within Namibia. Further studies are needed to understand the epidemiology and impact of PCV-3 on pig productivity and wildlife health.
Article
Parasitology
Chutchai Piewbang, Panida Poonsin, Pattiya Lohavicharn, Panitnan Punyathi, Sawang Kesdangsakonwut, Tanit Kasantikul, Somporn Techangamsuwan
Summary: This study provides insights into the pathology of natural SARS-CoV-2 infection in dogs, revealing severe damage to the lungs and involvement of multiple organs. The findings suggest the potential utility of dogs as a model for studying SARS-CoV-2 infection in humans, highlighting the need for further investigation.
Article
Parasitology
Julian Avila-Jimenez, Juan David Gutierrez, Mariano Altamiranda-Saavedra
Summary: Leishmaniasis is a parasitic disease transmitted to humans by sandfly vectors and vertebrate hosts. This study used ecological niche modeling to investigate the potential distribution of host and vector species associated with cutaneous leishmaniasis transmission, revealing different distribution patterns under varying climatic conditions.
Article
Parasitology
Luis A. Gomez-Puerta, Juan Olazabal, Santiago Paredes, Juan Lopez, Miguel Anampa, Angelica Mondragon, Ana Vargas-Calla, Hugo Castillo
Summary: This study reports the first detection of Candidatus M. haemolamae infection in vicunas from the Pampa Galeras National Reserve in Peru, using molecular diagnosis. Tick-infested vicunas had a higher likelihood of being infected with Candidatus M. haemolamae compared to tick-free vicunas. Gender and age were not associated with infection.
Article
Parasitology
Berlin Londono-Renteria, Zakaria Seidu, Helena Lamptey, Michael F. Ofori, Lars Hviid, Mary Lopez-Perez
Summary: Heterozygous carriers of HbAS and HbAC have a reduced risk of severe malaria, but not immunity against Plasmodium falciparum infection. Antibody levels against gSG6-P1 peptide in Anopheles mosquito saliva can serve as a serological biomarker for exposure to Plasmodium infection. This study highlights the importance of studying the role of hemoglobinopathies in malaria transmission for improving control interventions.
Article
Parasitology
Imane Belbacha, Meryem El Azzouzi, Rajae Bensghir, Kamal Filali Marhoum, Khadija Hajjout, El Mir Elharti, Khalid Sadki, Hicham Oumzil
Summary: This study investigates the association of three SNPs in the APOBEC3G gene with disease outcomes in Moroccan HIV-1 infected patients. The rs2294367 CG genotype is strongly associated with protection against HIV-1 infection, particularly in older individuals.
Article
Parasitology
Tan Luong, Do Kien Tran, Anh Hung Pham, Thi Thu-Ha Hoang, Van Khang Pham, Quang Thai Pham, Thi Mai Hung Tran, Minh Hoa Luong, Thanh Long Pham, Jason K. Blackburn
Summary: This study examined the epidemiology of anthrax in Lai Chau province, Vietnam, using historical data. Spatial clusters of human and livestock anthrax were identified, and the characteristics of the disease were described. The study found that there were distinct differences between the high-risk areas for human and livestock anthrax, and most human cases occurred during specific seasons. Additionally, the decrease in livestock anthrax vaccine coverage was associated with an increase in disease incidence.
Article
Parasitology
Jin-tao Chen, Jian-bo Zhan, Ming-chao Zhu, Kai-ji Li, Man-qing Liu, Bin Hu, Kun Cai, Hai-rong Xiong, Shu-liang Chen, Wei-long Tan, Liang-jun Chen, Wei Hou
Summary: This study investigated the prevalence and variation of orthohantavirus in rodents and humans in Hubei province, China. It identified the diversity of orthohantaviruses circulating in the region, with the HV004-like subtype being the main genotype in rodents and patients. This highlights the importance of continued attention and research on orthohantaviruses, especially newly identified strains.