Article
Biochemistry & Molecular Biology
Caroline Rodrigues Chaves dos Reis, Hellen Valerio Chaves Moura de Souza, Rennan Papaleo Paes Leme, Frederico Silva Castelo-Branco, Tacio Vinicio Amorim Fernandes, Nubia Boechat, Luiza Rosaria Sousa Dias, Lucas Villas oas Hoelz
Summary: This study investigates the molecular mechanism of benzimidazole compounds as cruzain inhibitors through molecular docking and dynamics simulations. The results suggest that these inhibitors bind to cruzain through steric and hydrogen bonding interactions without altering its structure and compactness.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Parasitology
Natalia Erdens Maron Freitas, Fernanda Lopes Habib, Emily Ferreira Santos, Angelo Antonio Oliveira Silva, Natalia Dantas Fontes, Leonardo Maia Leony, Daniel Dias Sampaio, Marcio Cerqueira de Almeida, Filipe Dantas-Torres, Fred Luciano Neves Santos
Summary: This article reviews the technological advances in serological diagnosis of Chagas disease in dogs and cats. Dogs and cats are considered important for the maintenance of domestic transmission cycle of Trypanosoma cruzi, the causative agent of Chagas disease. However, there are no commercial tests available to detect past or active infections in these animals. The use of chimeric recombinant T. cruzi antigens may improve the diagnosis of chronic Chagas disease in dogs and cats.
PARASITES & VECTORS
(2022)
Article
Biochemistry & Molecular Biology
Lenci K. Vazquez-Jimenez, Alfredo Juarez-Saldivar, Rogelio Gomez-Escobedo, Timoteo Delgado-Maldonado, Domingo Mendez-Alvarez, Isidro Palos, Debasish Bandyopadhyay, Carlos Gaona-Lopez, Eyra Ortiz-Perez, Benjamin Nogueda-Torres, Esther Ramirez-Moreno, Gildardo Rivera
Summary: In this study, a ligand-based virtual screening was performed to identify potential TcTIM inhibitors. Molecular docking and molecular dynamics simulation analysis showed a favorable docking score of the BP5 compound on TcTIM, and a lower docking score on human TIM compared to the control ligand. Both BP2 and BP5 compounds exhibited good physicochemical and pharmacokinetic properties as new anti-T. cruzi agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Kariyemu Aihaiti, Jun Li, Nan-nan Xu, Dan Tang, Haji Akber Aisa
Summary: Six undescribed monoterpenoids and twelve known compounds were isolated from Hyssopus cuspidatus Boriss. Their structures were determined using spectroscopic analysis and their absolute configurations were confirmed by ECD calculations and single-crystal X-ray diffraction crystallography. The isolated compounds were tested for anti-inflammatory, antibacterial, and antitumor activities, with most of them exhibiting potent anti-inflammatory effects. Some compounds also showed inhibitory activities against certain bacteria and fungi. The study demonstrated the potential benefits of H. cuspidatus in the development of anti-inflammatory, antibacterial, and antitumor drugs.
Article
Chemistry, Applied
Kariyemu Aihaiti, Jun Li, Saimijiang Yaermaimaiti, Liu Liu, Xuelei Xin, Haji Akber Aisa
Summary: This study evaluated the chemical composition and bioactivities of Hyssopus cuspidatus and found that the ethyl acetate fraction exhibited antioxidant and antimicrobial activities. 64 compounds were identified through LC-MS/MS analysis, with phenolic compounds being the main components. 34 compounds were isolated, six of which were new and eighteen were discovered from H. cuspidatus for the first time. The major components, including rosmarinic acid, methyl rosmarinate, butyl rosmarinate, and salvigenin, were determined, and most of the isolated compounds showed significant or moderate antioxidant and antimicrobial activities.
Article
Infectious Diseases
Juan David Ramirez, Liyong Cao, Lissa Cruz-Saavedra, Carolina Hernandez, Sergio Castaneda, Marina Munoz, Nathalia Ballesteros, Radhika Banu, Paras Shrestha, Carlos Cordon-Cardo, Emilia Mia Sordillo, Alberto Paniz-Mondolfi
Summary: This study explores the feasibility of using epimastigotes to construct standard curves for quantifying parasitic loads in Chagas disease molecular diagnostics. The results indicate that there are no statistically significant differences in calculating parasitic loads in blood samples, regardless of the life stage used to construct the standard curves. This finding has practical implications for improving Chagas disease molecular diagnostic methods.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Andres Lizasoain, Daiana Mir, Matias Salvo, Viviana Bortagaray, Gisela Masachessi, Adrian Farias, Nelida Rodriguez-Osorio, Silvia Nates, Matias Victoria, Rodney Colina
Summary: This study assessed the diversity of enteroviruses through Illumina next-generation sequencing of VP1-amplicons obtained by RT-PCR directly applied to viral concentrates of 84 wastewater samples collected in Uruguay. Fifty out of the 84 samples were positive for enteroviruses, with 27 different types detected. The results revealed the circulation of EV-A71 sub-genogroup C2 in both Uruguay and Argentina since at least 2011-2012, as well as the emergence of a C1-like variant in Argentina.
Article
Biotechnology & Applied Microbiology
B. Barros Cota, D. Batista Carneiro de Oliveira, T. Carla Borges, A. Cristina Catto, C. Valverde Serafim, A. Rogelis Aquiles Rodrigues, M. Kohlhoff, C. Leomar Zani, A. Assuncao Andrade
Summary: The study evaluated the antifungal activity of Chamaecostus cuspidatus rhizome extracts against Candida and Trichophyton species. The extracts showed antifungal, fungicidal, and antibiofilm effects with greater selectivity for fungal cells. This suggests potential clinical applications in managing superficial mycoses caused by these fungal species.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Doireyner Daniel Velazquez-Ramirez, Jose A. De Fuentes-Vicente, Mustapha Debboun, Adalberto A. Perez de Leon, Cesar Irecta-Najera, Lorenzo Cruz-Mendez, Eduardo E. Espinoza-Medinilla, Hector Ochoa-Diaz-Lopez
Summary: This study reports the first documented case of Eratyrus cuspidatus infected with Trypanosoma cruzi in a human dwelling in Mexico, indicating an important adaptation process of this triatomine species to inhabit human environments.
VECTOR-BORNE AND ZOONOTIC DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Xingyu Liu, Jie Su, Geng Wang, Lihua Zheng, Guannan Wang, Ying Sun, Yongli Bao, Shuyue Wang, Yanxin Huang
Summary: The study demonstrates that hyssopuside (HY) isolated from Hyssopus cuspidatus exhibits anti-inflammatory effects by blocking the NF-kappa B signal transduction pathways. HY could potentially serve as a promising alternative phenolic agent for alleviating excessive inflammation in various inflammation-associated diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Kong Ling-Fei, Rong Xiao-Juan, Yan Pan, Qin Tuo, Zhang Xiao-Hui, Kang Yu-Tong, Cheng Bo, Su Wen-Ling, Gao Tian-Le, Tie Cai
Summary: Current drugs do not provide a complete cure or alter the course of asthma. Hyssopus cuspidatus Boriss extract (SXCF) has been used in Uyghur medicine to treat bronchial asthma, but little research has been done on its therapeutic mechanisms. This study investigated the therapeutic mechanism of SXCF in asthma by exploring its effects on the metabolic network of lipid mediators (LMs).
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Parasitology
Carolina Valenca-Barbosa, Paula Finamore-Araujo, Otacilio C. Moreira, Jose Gabriel Vergara-Meza, Marcus Vinicius Niz Alvarez, Juliana R. Nascimento, Andre Borges-Veloso, Maria Carolina Viana, Mauricio Lilioso, Danilo Ciccone Miguel, Fernanda Ramos Gadelha, Marta Maria Geraldes Teixeira, Carlos Eduardo Almeida
Summary: This study identified different genotypes of Trypanosoma cruzi in Triatoma brasiliensis populations in distinct geographic and ecotypic locations in Brazil. The results showed a clear ecotypic segregation between TcI and TcII, with TcI predominating in peridomestic ecotopes. Additionally, T. brasiliensis from Rio Grande do Norte had a higher T. cruzi load, with TcII having more than twice the parasite load of TcI.
Article
Gastroenterology & Hepatology
Menglei Shuai, Yuanqing Fu, Hai-Li Zhong, Wanglong Gou, Zengliang Jiang, Yuhui Liang, Zelei Miao, Jin-Jian Xu, Tien Huynh, Mark L. Wahlqvist, Yu-Ming Chen, Ju-Sheng Zheng
Summary: This study investigated the determinants and long-term stability of the gut mycobiome in middle-aged and elderly individuals. It also explored the ecological links between gut fungi, bacteria, and faecal metabolome, as well as the potential influence of gut fungi on metabolic health through interactions with gut bacterial functions and metabolites. The results showed that the composition of the gut mycobiome was temporally stable and mainly influenced by age, long-term habitual diet, and host physiological states. Dairy consumption was found to be associated with certain gut fungi, while other gut fungi were associated with insulin resistance and blood cholesterol levels through interactions with gut bacterial diversity and faecal histidine.
Article
Biology
Alejandro Diaz-Hernandez, Maria Cristina Gonzalez-Vazquez, Minerva Arce-Fonseca, Olivia Rodriguez-Morales, Maria Lilia Cedillo-Ramirez, Alejandro Carabarin-Lima
Summary: There is currently no vaccine available for American trypanosomiasis caused by Trypanosoma cruzi. However, the consensus sequence of the enolase protein shows promising immunogenic properties, which could be used to develop a vaccine against Chagas disease.
Article
Microbiology
Alina Iovleva, Mustapha M. Mustapha, Marissa P. Griffith, Lauren Komarow, Courtney Luterbach, Daniel R. Evans, Eric Cober, Sandra S. Richter, Kirsten Rydell, Cesar A. Arias, Jesse T. Jacob, Robert A. Salata, Michael J. Satlin, Darren Wong, Robert A. Bonomo, David van Duin, Vaughn S. Cooper, Daria Van Tyne, Yohei Doi
Summary: Carbapenem-resistant Acinetobacter baumannii (CRAb) is a significant threat to public health, particularly for hospitalized patients. The Study Network of Acinetobacter as a Carbapenem-Resistant Pathogen (SNAP) conducted whole-genome sequencing (WGS) analysis of 120 CRAb patients from four U.S. centers, revealing the dominance of the ST2(Pas) lineage within clonal complex 2 (CC2), as well as the emergence of sublineages with different antibiotic resistance phenotypes. The study emphasizes the need for real-time surveillance and molecular epidemiology to understand CRAb dissemination and clinical impact.
Article
Parasitology
Anita G. Villacis, Juan Jose Bustillos, Stephanie Depickere, Dino Sanchez, Cesar A. Yumiseva, Ana Troya-Zuleta, Christian Barnabe, Mario J. Grijalva, Simone Frederique Breniere
Review
Infectious Diseases
Andrea Vela, Marco Coral-Almeida, Denis Sereno, Jaime A. Costales, Christian Barnabe, Simone Frederique Breniere
Summary: The study identified that genetic variability in T. cruzi may influence sensitivity to benznidazole, emphasizing the importance of uniform experimental conditions and screening diverse T. cruzi strains during the optimization of new drug candidates for Chagas disease treatment.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Veterinary Sciences
Jeiczon Jaimes-Duenez, Edgar Mogollon-Waltero, Norberto Arias-Landazabal, David Rangel-Pachon, Angela Jimenez-Leano, Ana Mejia-Jaramillo, Omar Triana-Chavez
Summary: In South America, Colombia ranks as the third-largest livestock producer with approximately 28.8 million cattle, where Colombian Creole cattle represent around 1% of the livestock population. Animal Trypanosomiasis (AT) is a critical problem in the livestock industry, reducing production by about 30%. This study reports the molecular prevalence and clinical traits associated with Trypanosoma spp. infection in three Colombian Creole cattle breeds. The study found significant variations in prevalence and clinical signs associated with the infection, suggesting different levels of trypanotolerance in the breeds and potential effects of environmental variables on prevalence and clinical characteristics.
PREVENTIVE VETERINARY MEDICINE
(2021)
Article
Infectious Diseases
Omar Cantillo-Barraza, Manuel Medina, Sara Zuluaga, Maria Isabel Blanco, Rodrigo Caro, Jeiczon Jaimes-Duenez, Virgilio Beltran, Samanta C. C. Xavier, Omar Triana-Chavez
Summary: This study highlights the distribution of synanthropic triatomine bugs in Boyaca, Colombia, with T. dimidiata becoming the most prevalent vector after successful control programs targeting R. prolixus. T. venosa, P. geniculatus, and P. rufotuberculatus also increase the risk of Chagas disease transmission in the region, suggesting the need for ongoing surveillance and control measures. The presence of residual R. prolixus populations poses a threat to the progress made in eliminating intradomiciliary transmission of T. cruzi.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Infectious Diseases
Yurany Granada, Ana Maria Mejia-Jaramillo, Sara Zuluaga, Omar Triana-Chavez
Summary: The study found that Aedes aegypti mosquitoes in different Colombian cities have developed resistance to some pyrethroid insecticides due to allelic substitutions on the voltage-gated sodium channel gene known as kdr mutations. While kdr mutations play a role in conferring low levels of resistance, other mechanisms such as metabolic enzymes also contribute to the resistance. The findings suggest that genetic surveillance of mosquito populations is essential for monitoring resistance emergence and improving disease control measures.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Microbiology
Lidia Gual-Gonzalez, Catalina Arango-Ferreira, Laura Camila Lopera-Restrepo, Omar Cantillo-Barraza, Daniela Velasquez Marin, Natalia Restrepo Bustamante, Omar Triana-Chavez, Melissa S. Nolan
Summary: Chagas disease, caused by Trypanosoma cruzi infection, is a major cause of heart failure in Latin America. Early diagnosis and treatment are crucial to prevent irreversible myocardial damage. However, in Colombia, less than 1% of cases are treated due to various barriers. This study presents two cases of pediatric oral transmission of Chagas disease in an area of Colombia where this mode of transmission was previously unreported.
Article
Entomology
Andrea Arevalo-Cortes, Yurany Granada, David Torres, Omar Triana-Chavez
Summary: This study analyzed the characteristics of Aedes aegypti populations from different cities in Colombia, including lifespan, fecundity, and mortality. The study found that each population had unique features and patterns, which are important for determining the timing of insecticide application and surveillance.
Article
Parasitology
Lopez-Dominguez Jaime, Lopez-Monteon Aracely, Ochoa-Martinez Paulina, Eric Dumonteil, Christian Barnabe, Etienne Waleckx, Ruben Gustavo Hernandez-Giles, Angel Ramos-Ligonio
Summary: This study aimed to characterize Mexican isolates of T. cruzi and evaluate their susceptibility to NFX. The results showed a high variability in the susceptibility to NFX of the T. cruzi isolates in Central and Southeastern Mexico, suggesting the presence of naturally resistant isolates circulating in the country. These findings have important implications for treatment policies for Chagas disease patients.
ACTA PARASITOLOGICA
(2022)
Article
Virology
Andrea Arevalo-Cortes, Ashish Damania, Yurany Granada, Sara Zuluaga, Rojelio Mejia, Omar Triana-Chavez
Summary: This study identified high Zika virus infection rates in Ae. aegypti females from Colombian rural municipalities with deficient water supply. Differences in diversity were observed between infective and non-infective forms in the presence of natural Zika infection. Bacteria associated with Zika virus infection and lambda-cyhalothrin resistance were detected, suggesting a potential role in virus entry and insecticide bioremediation.
Article
Polymer Science
Nicolas Montoya-Escobar, Daniel Ospina-Acero, Jorge Andres Velasquez-Cock, Catalina Gomez-Hoyos, Angelica Serpa Guerra, Piedad Felisinda Ganan Rojo, Lina Maria Velez Acosta, Juan Pablo Escobar, Natalia Correa-Hincapie, Omar Triana-Chavez, Robin Zuluaga Gallego, Pablo M. Stefani
Summary: In this study, the crystallinity of three different types of cellulose was investigated using FTIR and XRD methods. A deconvolution method was developed to accurately estimate the crystallinity index. The effect of milling time on crystallinity was observed.
Article
Entomology
Lidia Gual-Gonzalez, Manuel Medina, Cesar Valverde-Castro, Virgilio Beltran, Rodrigo Caro, Omar Triana-Chavez, Melissa S. Nolan, Omar Cantillo-Barraza
Summary: This study evaluated the feasibility and effectiveness of micro-encapsulated insecticide paints in controlling vector species in a rural community in Colombia. The results showed the potential of this approach to prevent colonization and reduce the risk of disease transmission. The complementary use of insecticide spraying and micro-encapsulated paints could enhance public health efforts and reduce costs.
Article
Infectious Diseases
Christian Barnabe, Simone Frederique Breniere, Soledad Santillan-Guayasamin, Emmanuel J. P. Douzery, Etienne Waleckx
Summary: Chagas disease caused by Trypanosoma cruzi is a neglected disease in Latin America. Genetic characterization of T. cruzi strains is crucial for epidemiological studies. This study used Next Generation Sequencing to sequence mitochondrial genes, single-copy nuclear genes, and the repeated intergenic part of the mini-exon gene to analyze T. cruzi genetic diversity. The results showed that single-copy nuclear genes are the gold standard for strain characterization, and mitochondrial markers are necessary for detecting introgression and heteroplasmy. However, caution should be exercised when using mini-exon sequences for typing and phylogenetic studies.
INFECTION GENETICS AND EVOLUTION
(2023)
Article
Multidisciplinary Sciences
Arnaud Cannet, Camille Simon-Chane, Mohammad Akhoundi, Aymeric Histace, Olivier Romain, Marc Souchaud, Pierre Jacob, Darian Sereno, Karine Mouline, Christian Barnabe, Frederic Lardeux, Philippe Bousses, Denis Sereno
Summary: This study presents a new identification method using deep learning that can accurately classify and assign Anopheles species based on their wing interferential patterns. The method achieves high accuracy, including 100% accuracy for morphologically indistinguishable species within the Gambiae complex.
SCIENTIFIC REPORTS
(2023)
Article
Plant Sciences
Michel Dollet, Sandrine Fabre, Maeva Beaumont, Christian Barnabe, Yak Namaliu, Alfred Kembu, Roland Bourdeix
Summary: Coconut plays a significant role in the nutrition and livelihoods of millions of households in the Asia-Pacific region, particularly in Papua New Guinea. However, the coconut diversity in the region is under threat from Bogia coconut syndrome, a new lethal phytoplasma disease. This study identified a new phytoplasma associated with the disease and found it to be the first LYTS group member in the Asian-Pacific region.
TROPICAL PLANT PATHOLOGY
(2022)
Article
Plant Sciences
Cesil Solis-Medina, Sara Zuluaga Aguirre, Omar Triana-Chavez, Omar Cantillo-Barraza
Summary: The study provides an update on the infection status of P. geniculatus and the presence of infected P. lignarius in the Guainia region in Colombia, highlighting the importance of continuous search and characterization of triatomine bugs for Chagas disease surveillance programs.
ACTA BIOLOGICA COLOMBIANA
(2021)
Article
Parasitology
Gabriela Martinez Moura Tavares, Hannar Angelica de Melo Alverga, Estela Moraes Felix, Giovana de Oliveira Dichman, Gabriel Monteiro Pinheiro, Yara Juliano, Priscila Paruci, Dennis Minoru Fujita, Lucas Melo Neves, Marina Tiemi Shio, Luiz Henrique da Silva Nali
Summary: This study investigated the frequency of N. gonorrhoeae infection in women in a poor area of São Paulo and found that most of the strains detected showed resistance to one or more antimicrobials.
Article
Parasitology
Qian Yao, Ying-Ying Fan, Shuang Huang, Gui-Rong Hu, Jun-Ke Song, Xin Yang, Guang-Hui Zhao
Summary: This study found that the expression of miR-4521 was upregulated during C. parvum infection, and this upregulation was related to the TLR/NF-kappa B signal pathway. Additionally, miR-4521 promoted the propagation of C. parvum in HCT-8 cells by regulating BCL2-mediated cell apoptosis through targeting foxm1.
Article
Parasitology
Cho Naing, Maxine A. Whittaker, Wong Siew Tung, Htar Aung, Joon Wah Mak
Summary: This study aimed to estimate the prevalence of zoonotic brugian filariasis in animals and compare it with the prevalence in humans in the same area. The findings suggest that cats, dogs, and leaf-eating monkeys may serve as potential reservoirs for human brugian filariasis.
Review
Parasitology
Raissa Nogueira de Brito, Susan Tanner, Julie Velasquez Runk, Juliana Hoyos
Summary: This study conducted a scoping review to identify major research themes and knowledge gaps in the social science literature on leishmaniases or Chagas disease. The findings showed that research in this field mainly focuses on the sociocultural, economic, historical, and political dimensions of the diseases. Future research should pay more attention to how social institutions and economic factors shape disease education, control measures, healthcare access, and quality of life of affected individuals.
Article
Parasitology
Minghao Zheng, Mengyao Zhang, Hao Li, Shipo Wu, Yuee Zhao, Jinlong Zhang, Yunyue Zhou, Mohamed Boie Jalloh, Kun Zhang, Lina Chen, Zhiqiang Mi, Yong Cui, Lihua Hou
Summary: Rapid and convenient detection of Plasmodium falciparum, the deadliest malaria parasite in Africa, is crucial for malaria eradication efforts in medical resource-limited settings. A CRISPR-based diagnostic method that can detect P. falciparum without nucleic acid extraction was developed and showed high sensitivity and consistency with qPCR test. It can also detect artemisinin-resistant strains and other laboratory-cultured strains. This method has great potential for clinical testing and large-scale community screening in Africa and other regions.
Article
Parasitology
Fabian Correa-Morales, Cassandra Gonzalez-Acosta, David Ibarra-Ojeda, Miguel Moreno-Garcia
Summary: Since 2002, West Nile Virus (WNV) has been reported in 18 states in Mexico. This paper discusses the proposed hypotheses for the absence of WNV outbreaks in Latin America and provides a context-specific explanation for Mexico.
Article
Parasitology
Umberto Molini, Lauren M. Coetzee, Vernon Christians, Maria Y. Hemberger, Bernard Chiwome, Maria Amukwaya, Siegfried Khaiseb, Giovanni Cattoli, William G. Dundon, Giovanni Franzo
Summary: Porcine circovirus 3 (PCV-3) has been reported globally since its first identification in 2015. Limited data on PCV-3 in Africa led to a study in Namibia, which found a high prevalence of PCV-3 in backyard piggeries, but not in commercial farms with higher biosecurity measures. The source of viral introduction and factors such as semen importation, feeding backyard pigs with human food waste, pig exchanges, and wildlife movements may be involved in the dispersal of PCV-3 within Namibia. Further studies are needed to understand the epidemiology and impact of PCV-3 on pig productivity and wildlife health.
Article
Parasitology
Chutchai Piewbang, Panida Poonsin, Pattiya Lohavicharn, Panitnan Punyathi, Sawang Kesdangsakonwut, Tanit Kasantikul, Somporn Techangamsuwan
Summary: This study provides insights into the pathology of natural SARS-CoV-2 infection in dogs, revealing severe damage to the lungs and involvement of multiple organs. The findings suggest the potential utility of dogs as a model for studying SARS-CoV-2 infection in humans, highlighting the need for further investigation.
Article
Parasitology
Julian Avila-Jimenez, Juan David Gutierrez, Mariano Altamiranda-Saavedra
Summary: Leishmaniasis is a parasitic disease transmitted to humans by sandfly vectors and vertebrate hosts. This study used ecological niche modeling to investigate the potential distribution of host and vector species associated with cutaneous leishmaniasis transmission, revealing different distribution patterns under varying climatic conditions.
Article
Parasitology
Luis A. Gomez-Puerta, Juan Olazabal, Santiago Paredes, Juan Lopez, Miguel Anampa, Angelica Mondragon, Ana Vargas-Calla, Hugo Castillo
Summary: This study reports the first detection of Candidatus M. haemolamae infection in vicunas from the Pampa Galeras National Reserve in Peru, using molecular diagnosis. Tick-infested vicunas had a higher likelihood of being infected with Candidatus M. haemolamae compared to tick-free vicunas. Gender and age were not associated with infection.
Article
Parasitology
Berlin Londono-Renteria, Zakaria Seidu, Helena Lamptey, Michael F. Ofori, Lars Hviid, Mary Lopez-Perez
Summary: Heterozygous carriers of HbAS and HbAC have a reduced risk of severe malaria, but not immunity against Plasmodium falciparum infection. Antibody levels against gSG6-P1 peptide in Anopheles mosquito saliva can serve as a serological biomarker for exposure to Plasmodium infection. This study highlights the importance of studying the role of hemoglobinopathies in malaria transmission for improving control interventions.
Article
Parasitology
Imane Belbacha, Meryem El Azzouzi, Rajae Bensghir, Kamal Filali Marhoum, Khadija Hajjout, El Mir Elharti, Khalid Sadki, Hicham Oumzil
Summary: This study investigates the association of three SNPs in the APOBEC3G gene with disease outcomes in Moroccan HIV-1 infected patients. The rs2294367 CG genotype is strongly associated with protection against HIV-1 infection, particularly in older individuals.
Article
Parasitology
Tan Luong, Do Kien Tran, Anh Hung Pham, Thi Thu-Ha Hoang, Van Khang Pham, Quang Thai Pham, Thi Mai Hung Tran, Minh Hoa Luong, Thanh Long Pham, Jason K. Blackburn
Summary: This study examined the epidemiology of anthrax in Lai Chau province, Vietnam, using historical data. Spatial clusters of human and livestock anthrax were identified, and the characteristics of the disease were described. The study found that there were distinct differences between the high-risk areas for human and livestock anthrax, and most human cases occurred during specific seasons. Additionally, the decrease in livestock anthrax vaccine coverage was associated with an increase in disease incidence.
Article
Parasitology
Jin-tao Chen, Jian-bo Zhan, Ming-chao Zhu, Kai-ji Li, Man-qing Liu, Bin Hu, Kun Cai, Hai-rong Xiong, Shu-liang Chen, Wei-long Tan, Liang-jun Chen, Wei Hou
Summary: This study investigated the prevalence and variation of orthohantavirus in rodents and humans in Hubei province, China. It identified the diversity of orthohantaviruses circulating in the region, with the HV004-like subtype being the main genotype in rodents and patients. This highlights the importance of continued attention and research on orthohantaviruses, especially newly identified strains.
