Review
Medicine, General & Internal
Matiullah Masroor, Ashfaq Ahmad, Yixuan Wang, Nianguo Dong
Summary: Coronary artery bypass grafting (CABG) is the standard surgical procedure for treating multivessel and left main coronary artery disease. Ensuring graft patency during and after CABG surgery is crucial to prevent complications. Technical errors during anastomosis are a leading cause of early graft failure. Various techniques and modalities have been developed to evaluate graft patency and address any issues before they become significant. This review article aims to discuss the strengths and limitations of these techniques to identify the best modality for assessing graft patency during and after CABG surgery.
Article
Multidisciplinary Sciences
Entesar Zawam Dalah, Abdulmunhem Obaideen, Sabaa Anam, Khalid Alzimami, Layal Khalid Jambi, David A. Bradley
Summary: This study estimated the lifetime risk of lung cancer in CAD patients receiving enhanced CCTA and unenhanced CTCS. The results showed significant differences in patient effective dose and organ doses between CTCS and CCTA. Female patients, younger patients, and those undergoing both CCTA and CTCS scans had higher risk. The mAs parameter had the greatest impact on patient dose.
Article
Cardiac & Cardiovascular Systems
Hazem Omran, Marcus A. Deutsch, Elena Groezinger, Armin Zittermann, Andre Renner, Johannes T. Neumann, Dirk Westermann, Paul Myles, Burim Ramosaj, Markus Pauly, Werner Scholtz, Kavous Hakim-Meibodi, Tanja K. Rudolph, Jan Gummert, Volker Rudolph
Summary: This study aimed to determine the optimal cut-off value and timing for high-sensitivity cardiac troponin I (hs-cTnI) in post-operative clinical decision-making. The results showed that hs-cTnI levels measured 12-16 hours after surgery with a cut-off of 8000 ng/L were most strongly correlated with the decision to repeat revascularization. Early hs-cTnI measurements had limited usefulness for clinical decision-making, while measurements at later time-points were more informative.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Yu-Ting Cheng, Dong-Yi Chen, Victor Chien-Chia Wu, An-Hsun Chou, Shang-Hung Chang, Pao-Hsien Chu, Shao-Wei Chen
Summary: The effect of previous coronary stenting on subsequent coronary artery bypass graft is inconclusive. This retrospective study using Taiwan's National Health Insurance Database found that previous coronary stenting before multivessel coronary artery bypass graft significantly increased 30-day mortality but did not affect late survival. However, patients who had coronary stenting before coronary artery bypass graft experienced more revascularization events during late follow-up.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Donald S. Likosky, Raymond J. Strobel, Xiaoting Wu, Robert S. Kramer, Baron L. Hamman, James K. Brevig, Michael P. Thompson, Amir A. Ghaferi, Min Zhang, Eric J. Lehr
Summary: This study evaluated whether interhospital variation in mortality rates for coronary artery bypass grafting was driven by complications and failure to rescue. The study found a positive correlation between hospital failure to rescue rates and complications, suggesting that early recognition and management of complications are important factors in improving the success of coronary artery bypass grafting.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Review
Cardiac & Cardiovascular Systems
Alexander Chua, Daniel Adams, Damini Dey, Ron Blankstein, Timothy Fairbairn, Jonathon Leipsic, Abdul Rahman Ihdayhid, Brian Ko
Summary: Epidemiological studies have found differences in the development of coronary artery disease between East Asians and Caucasians, with East Asians exhibiting less calcification and high-risk plaque. South Asians, on the other hand, show higher rates of coronary calcification and stenosis. Future research may clarify the prognostic value of cardiac CT in South Asians and guide preventative therapy for coronary artery disease in both East and South Asians.
Article
Cardiac & Cardiovascular Systems
Sripal Bangalore, Eric R. Bates, Theresa M. Beckie, James M. Bischoff, John A. Bittl, Mauricio G. Cohen, J. Michael DiMaio, Creighton W. Don, Stephen E. Fremes, Mario F. Gaudino, Zachary D. Goldberger, Michael C. Grant, Jang B. Jaswal, Paul A. Kurlansky, Roxana Mehran, Thomas S. Metkus, Lorraine C. Nnacheta, Sunil V. Rao, Frank W. Sellke, Garima Sharma, Celina M. Yong, Brittany A. Zwischenberger, Patrick T. O'Gara, Joshua A. Beckman, Glenn N. Levine, Sana M. Al-Khatib, Anastasia L. Armbruster, Kim K. Birtcher, Joaquin E. Cigarroa, Lisa de las Fuentes, Anita Deswal, Dave L. Dixon, Lee A. Fleisher, Federico Gentile, Zachary D. Goldberger, Bulent Gorenek, Norrisa Haynes, Adrian F. Hernandez, Mark A. Hlatky, Jose A. Joglar, W. Schuyler Jones, Joseph E. Marine, Daniel B. Mark, Debabrata Mukherjee, Latha P. Palaniappan, Mariann R. Piano, Tanveer Rab, Erica S. Spatz, Jacqueline E. Tamis-Holland, Duminda N. Wijeysundera, Y. Joseph Woo
Summary: This article introduces the importance and application of coronary artery revascularization guidelines, which provide a patient-centric approach for treating patients with significant coronary artery disease. The guidelines are supported by relevant literature.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Christian P. Houbois, Gauri Karur, Jennifer Fratesi, Micheal C. McInnis
Summary: The prevalence of LCA in the study was 11%, with a majority being unilateral and having an average vessel length of 2 intercostal spaces. Gender had no significant impact on vessel distribution, and there was substantial agreement among observers in detecting LCA.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Philipp T. Moser, Ruediger Schernthaner, Christian Loewe, Andreas Strassl, Felix Denzinger, Sebastian Faby, Michael Wels, Volha Nizhnikava, Keziban Uyanik-Uenal, Andreas Zuckermann, Marie-Elisabeth Stelzmueller, Dietrich Beitzke
Summary: In cardiac transplant patients, the fat attenuation index (FAI) in coronary CT angiography (CCTA) may predict outcomes, but its use has not been evaluated in these patients.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Toshimitsu Tsugu, Kaoru Tanaka, Dries Belsack, Yuji Nagatomo, Mayuko Tsugu, Jean-Francois Argacha, Bernard Cosyns, Nico Buls, Michel De Maeseneer, Johan De Mey
Summary: In non-obstructive coronary artery disease, the decline of CT-derived fractional flow reserve (FFRCT) depends not only on vessel length but also on the lumen volume. A new marker, the ratio of lumen volume to vessel length (V/L ratio), was found to be the strongest predictor of distal FFRCT.
EUROPEAN RADIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Alexander Vladimirovich Ivanov, Mikhail Aleksandrovich Popov, Arkady Andreevich Metelkin, Valery Vasil'evich Aleksandrin, Evgeniy Gennad'evich Agafonov, Maria Petrovna Kruglova, Ekaterina Vladimirovna Silina, Victor Aleksandrovich Stupin, Ruslan Andreevich Maslennikov, Aslan Amirkhanovich Kubatiev
Summary: Coronary artery disease (CAD) and coronary artery bypass graft (CABG) are associated with a decrease in blood glutathione (bGSH) level. This study aimed to examine the associations of bGSH with glucose and plasma aminothiols in CAD patients before CABG and in the early postoperative period. The results showed that bGSH and its redox status were lower in CAD patients at admission, and CABG had no significant effect on these parameters except for an increase in the bGSH/hemoglobin ratio. Additionally, an association was found between an increase in oxidized GSH in the blood after surgery and fasting glucose levels.
Article
Medicine, General & Internal
Tzu-Hsiang Lin, Chi-Wei Wang, Ching-Hui Shen, Keng-Hao Chang, Chih-Hung Lai, Tsun-Jui Liu, Kuan-Ju Chen, Yu-Wei Chen, Wen-Lieng Lee, Chieh-Shou Su
Summary: The study found that in real-world practice, robotic-assisted CABG (R-CABG) for patients with multivessel coronary artery disease (MVD) was associated with lower in-hospital and long-term mortalities compared to conventional CABG (C-CABG). However, there were no significant differences between the two groups in terms of target lesion revascularization, target vessel revascularization, myocardial infarction, and stroke.
Article
Cardiac & Cardiovascular Systems
Daniel A. Jones, Anne-Marie Beirne, Matthew Kelham, Krishnaraj S. Rathod, Mervyn Andiapen, Lucinda Wynne, Thomas Godec, Nasim Forooghi, Rohini Ramaseshan, James C. Moon, Ceri Davies, Christos V. Bourantas, Andreas Baumbach, Charlotte Manisty, Andrew Wragg, Amrita Ahluwalia, Francesca Pugliese, Anthony Mathur, BYPASS-CTCA Trial Comm Investigators
Summary: This study assessed the benefit of computed tomography cardiac angiography (CTCA) in patients with previous coronary artery bypass grafting referred for invasive coronary angiography (ICA). The results showed that CTCA before ICA led to reductions in procedure time and contrast-induced nephropathy, with improved patient satisfaction.
Article
Pediatrics
Diana van Stijn-Bringas Dimitriades, Nils Planken, Irene Kuipers, Taco Kuijpers
Summary: This study compared the diagnostic potential of cCTA and CMR in assessing coronary arteries in children with KD, finding that cCTA may be a more sensitive tool for detecting CAAs compared to CMR.
FRONTIERS IN PEDIATRICS
(2021)
Article
Health Care Sciences & Services
Po-Shun Hsu, Jia-Lin Chen, Shih-Ying Sung, Yi-Ting Tsai, Chih-Yuan Lin, Yi-Fan Wu, Chien-Sung Tsai
Summary: This study compares the hemorheological and inflammatory changes before and after coronary artery bypass graft (CABG) surgery and finds that hyperviscosity persists for almost one week after the surgery. Inflammatory markers are also correlated with hemorheological changes. Understanding the interplay between inflammation and hemorheological properties is crucial for patient care.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jan Vosshenrich, Ivan Nesic, Joshy Cyriac, Daniel T. Boll, Elmar M. Merkle, Tobias Heye
Summary: The study aimed to investigate common errors in residents' preliminary reports and determine if structured reporting impacted error types and frequencies. Changes in report content were tracked for radiology reports and it was found that structured reporting reduced overall error rates but did not affect occurrence of the most common errors, which were laterality discriminator confusions and descriptor misregistrations. Increased error awareness and measures to improve report correctness and ensure patient safety are necessary.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jan Vosshenrich, Christoph J. Zech, Tobias Heye, Tuyana Boldanova, Geoffrey Fucile, Stefan Wieland, Markus H. Heim, Daniel T. Boll
Summary: This study investigated the use of nested multiparametric decision tree models based on tumor size and CT texture parameters to predict HCC lesion response to TACE treatment. The results showed that these models can accurately predict complete response and progressive disease in HCC lesions.
EUROPEAN RADIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Matthias Thielmann, David Corteville, Gabor Szabo, Madhav Swaminathan, Andre Lamy, Lukas J. Lehner, Craig D. Brown, Nicolas Noiseux, Mohamed G. Atta, Elizabeth C. Squiers, Shai Erlich, Daniel Rothenstein, Bruce Molitoris, C. David Mazer
Summary: In high-risk patients undergoing cardiac surgery, a single 10 mg/kg dose of teprasiran significantly reduced the incidence, severity, and duration of early AKI compared to placebo.
Article
Hematology
Lars Saemann, Anne Grosskopf, Fabio Hoorn, Gabor Veres, Yuxing Guo, Sevil Korkmaz-Icoez, Matthias Karck, Andreas Simm, Folker Wenzel, Gabor Szabo
Summary: The study utilized Laser-Doppler-Flowmetry to investigate coronary microvascular function during machine perfusion, revealing significantly decreased relative LDF in ischemic hearts, indicating microvascular dysfunction. Control hearts had significantly lower flow at 100mmHg perfusion pressure compared to the ischemia group.
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
(2021)
Article
Biochemistry & Molecular Biology
Sevil Korkmaz-Icoez, Cenk Kocer, Alex A. Sayour, Patricia Kraft, Mona Benker, Sophia Abulizi, Adrian-Iustin Georgevici, Paige Brlecic, Tamas Radovits, Sivakkanan Loganathan, Matthias Karck, Gabor Szabo
Summary: This study showed that adding the SGLT-2 inhibitor canagliflozin to saline can protect vascular grafts from ischemia/reperfusion injury, and significantly improve endothelial dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Enoch Akowuah, Ruth A. Benson, Edward J. Caruana, Govind Chetty, John Edwards, Stefano Forlani, George Gradinariu, Gavin J. Murphy, Aung Ye Oo, Akshay J. Patel, Brenda Ridley, Luke J. Rogers, Julie Sanders, Nathan Tyson, Ricky Vaja
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Review
Genetics & Heredity
Roland Stengl, Bence Agg, Miklos Polos, Gabor Matyas, Gabor Szabo, Bela Merkely, Tamas Radovits, Zoltan Szabolcs, Kalman Benke
Summary: Marfan syndrome is a genetic connective tissue disorder affecting cardiovascular, musculoskeletal, and ocular systems. Prophylactic aortic root replacement is crucial for preventing aortic dissection, but more accurate risk stratification systems are needed. Studying predictors of severe cardiovascular manifestations in MFS patients may lead to improved risk stratification and better outcomes.
ORPHANET JOURNAL OF RARE DISEASES
(2021)
Article
Cardiac & Cardiovascular Systems
Lars Saemann, Alina Zubarevich, Folker Wenzel, Jasmin Soethoff, Sivakkanan Loganathan, Sevil Korkmaz-Icoz, Matthias Karck, Gabor Szabo, Gabor Veres
Summary: The study demonstrated that skeletonized ITA harvesting significantly affects intrasternal microcirculation, and the quality of surgical preparation can also impact microcirculation. To reduce the risk of complications in deep sternal wound healing, excessive surgical damage and coagulation of satellite veins should be avoided as much as possible.
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2021)
Article
Medicine, General & Internal
Sameer Al-Maisary, Mina Farag, Willem Hendrik Te Gussinklo, Jamila Kremer, Sven T. Pleger, Florian Leuschner, Matthias Karck, Gabor Szabo, Rawa Arif
Summary: The study compared patients undergoing transapical transcatheter aortic valve implantation to those undergoing sutureless and rapid-deployment aortic valve implantation. The results showed comparable in-hospital mortality rates, age, and operative risk scores between the two groups, but a higher intraoperative blood transfusion volume in the sutureless and rapid-deployment valve group. No significant differences were observed in postoperative renal failure, cerebrovascular accidents, and pacemaker implantation rates. Both procedures had similar estimated survival rates after 6 months.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cell Biology
Viktor Banhegyi, Attila Enyedi, Gabor aron Fulop, Attila Olah, Ivetta Manyine Siket, Csongor Varadi, Klaudia Bottyan, Maria Lodi, Alexandra Csongradi, Azeem J. Umar, Miklos Fagyas, Daniel Czuriga, Istvan edes, Miklos Polos, Bela Merkely, Zoltan Csanadi, Zoltan Papp, Gabor Szabo, Tamas Radovits, Istvan Takacs, Attila Toth
Summary: Circulating ACE activity correlates with left ventricular ACE rather than lung ACE in humans, indicating tight coordination by genotype-dependent expression, endogenous inhibition, and secretion mechanisms.
Article
Cardiac & Cardiovascular Systems
Sevil Korkmaz-Icoez, Shiliang Li, Regina Huettner, Mihaly Ruppert, Tamas Radovits, Sivakkanan Loganathan, Alex Ali Sayour, Paige Brlecic, Felix Lasitschka, Matthias Karck, Gabor Szabo
Summary: Protecting donor hearts with mesenchymal stem cell conditioned medium significantly improves post-transplant cardiac function in 15-month-old rats, reducing ischemia/reperfusion injury. Regulation of pro-inflammatory cytokines and antioxidant genes may be a key mechanism for the protective effect.
ZEITSCHRIFT FUR HERZ THORAX UND GEFASSCHIRURGIE
(2021)
Article
Cardiac & Cardiovascular Systems
Lars Saemann, Sevil Korkmaz-Icoz, Fabio Hoorn, Gabor Veres, Patricia Kraft, Adrian-Iustin Georgevici, Maik Brune, Yuxing Guo, Sivakkanan Loganathan, Folker Wenzel, Matthias Karck, Gabor Szabo
Summary: The study showed that using HTK-N solution for machine perfusion can improve contractility of CD-hearts, reduce oxidative and nitrosative stress, and prevent cardiomyocyte swelling and necrosis.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Biochemistry & Molecular Biology
Gabor Veres, Kalman Benke, Roland Stengl, Yang Bai, Klara Aliz Stark, Alex Ali Sayour, Tamas Radovits, Sivakkanan Loganathan, Sevil Korkmaz-Icoez, Matthias Karck, Gabor Szabo
Summary: Aspirin preconditioning may be beneficial for the patency of arterial bypass grafts in coronary artery bypass grafting (CABG), improving endothelial function and reducing ischemia-reperfusion injury.
Article
Cardiac & Cardiovascular Systems
Mahmoud Diab, Thomas Lehmann, Wolfgang Bothe, Payam Akhyari, Stephanie Platzer, Daniel Wendt, Antje-Christin Deppe, Justus Strauch, Stefan Hagel, Albrecht Guenther, Gloria Faerber, Christoph Sponholz, Marcus Franz, Andre Scherag, Ilia Velichkov, Miriam Silaschi, Jens Fassl, Britt Hofmann, Sven Lehmann, Rene Schramm, Georg Fritz, Gabor Szabo, Thorsten Wahlers, Klaus Matschke, Artur Lichtenberg, Mathias W. Pletz, Jan F. Gummert, Friedhelm Beyersdorf, Christian Hagl, Michael A. Borger, Michael Bauer, Frank M. Brunkhorst, Torsten Doenst
Summary: This study investigated the effect of hemoadsorption during cardiac surgery for infective endocarditis (IE) on postoperative organ dysfunction and found that hemoadsorption did not reduce the occurrence of organ dysfunction. Although hemoadsorption reduced cytokine levels during surgery, it did not have an impact on clinically relevant outcome measures.
Article
Cell Biology
Patrick R. Winterhalter, Mandy Wirkner, Babett Bartling, Kristin Waechter, Arina Urazova, Anne Grosskopf, Claudius Diez, Gabor Szabo, Andreas Simm
Summary: Increased expression of RAGE in cardiac tissue is well-known in the elderly, in diabetes mellitus, and after acute cardiac infarction or ischemia/reperfusion injuries. RAGE and its binding partners affect the clinical outcome of heart failure and may play a crucial role in accelerating the functional decline in cardiovascular aging. The study found that RAGE overexpression leads to negative effects on heart function, causing downregulation of energy metabolism-associated genes and decreased ATP production.
MECHANISMS OF AGEING AND DEVELOPMENT
(2022)