Article
Immunology
Raquel Bragante Gritte, Talita Souza-Siqueira, Rui Curi, Marcel Cerqueira Cesar Machado, Francisco Garcia Soriano
Summary: The reason why septic patients remain ill after hospital discharge is still unknown, leading to a high death rate post-discharge. Post-sepsis syndrome (PSS) is characterized by cognitive disabilities, physical functioning decline, difficulties in performing routine daily activities, and poor life quality. This condition of PSS often associates with reinfection and re-hospitalization, contributing to the high death rate.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Avin Hawez, Dler Taha, Anwar Algaber, Raed Madhi, Milladur Rahman, Henrik Thorlacius
Summary: The study found that miR-155 regulates pulmonary formation of NETs in abdominal sepsis via up-regulation of PAD4 and histone 3 citrullination, suggesting that targeting miR-155 could be an effective approach to reduce pulmonary damage in abdominal sepsis.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Clinical Neurology
Rebecca Isabella Sienel, Hiroharu Kataoka, Seong-Woong Kim, Fatma Burcu Seker, Nikolaus Plesnila
Summary: This study reveals that the adhesion of leukocytes to the cerebrovascular endothelium is transient and inhibiting this process can partially prevent ischemic brain injury.
FRONTIERS IN NEUROLOGY
(2022)
Article
Cell Biology
Denise Eckert, Felicitas Rapp, Ayele T. Tsedeke, Jessica Molendowska, Robert Lehn, Markus Langhans, Claudia Fournier, Franz Roedel, Stephanie Hehlgans
Summary: Low-dose irradiation has anti-inflammatory effects on endothelial cells, and the dose-effect relationship is non-linear. Laminar conditions contribute to increased expression of anti-oxidative factors and reduced intracellular ROS content, resulting in reduced leukocyte adhesion.
Article
Biology
Alex R. Schuurman, Tom D. Y. Reijnders, Anno Saris, Ivan Ramirez Moral, Michiel Schinkel, Justin de Brabander, Christine van Linge, Louis Vermeulen, Brendon P. Scicluna, W. Joost Wiersinga, Felipe A. Vieira Braga, Tom van der Poll
Summary: This study integrated single-cell data from patients with COVID-19, influenza, and non-infectious controls, revealing unique immune features in CAP patients caused by different pathogens, such as varied levels of NK cells and CD8 T EMRA cells.
Article
Medicine, General & Internal
Dijoia B. Darden, Gabriela L. Ghita, Zhongkai Wang, Julie A. Stortz, Maria-Cecilia Lopez, Michael C. Cox, Russell B. Hawkins, Jaimar C. Rincon, Lauren S. Kelly, Brittany P. Fenner, Tezcan Ozrazgat-Baslanti, Christiaan Leeuwenburgh, Azra Bihorac, Tyler J. Loftus, Frederick A. Moore, Scott C. Brakenridge, Henry Baker, Rhonda Bacher, Alicia M. Mohr, Lyle L. Moldawer, Philip A. Efron
Summary: The study found that sepsis survivors have unique blood leukocyte transcriptomes in late sepsis, indicating ongoing immune dyscrasia which could help understand the prognosis of sepsis patients with CCI.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Philipp von Hundelshausen, Kanin Wichapong, Hans-Joachim Gabius, Kevin H. Mayo
Summary: The trafficking and local activity of leukocytes are essential for various physiological processes. Microenvironments are complex due to the multiple mediators from diverse cell types playing regulated roles. Chemokines and galectins represent important effector molecules involved in inflammatory processes and have the capacity to form various molecular interactions in response to inflammation.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Zaida Abad-Jimenez, Sandra Lopez-Domenech, Celia Garcia-Gargallo, Teresa Vezza, Segundo Angel Gomez-Abril, Carlos Morillas, Pedro Diaz-Pozo, Rosa Falcon, Celia Banuls, Victor M. Victor, Milagros Rocha
Summary: This cohort study explored the molecular mechanisms involved in energy homeostasis in leukocytes of obese subjects one year after Roux-en-Y gastric bypass (RYGB) surgery. The surgery resulted in improved metabolic outcomes, reduced systemic inflammation, altered intracellular inflammatory pathways, enhanced autophagy/mitophagy markers, and decreased mitochondrial membrane potential.
Article
Biochemistry & Molecular Biology
Emanuel Moisa, Madalina Dutu, Dan Corneci, Ioana Marina Grintescu, Silvius Negoita
Summary: Bacterial and viral sepsis have distinct hematological patterns, with procalcitonin and RDW% showing the best discriminatory ability between them. Procalcitonin is also strongly correlated with disease severity in both types of sepsis. Other hematological parameters, such as leukocytes, monocytes, and neutrophils, also show good discriminative ability between sepsis types. However, some hematological parameters have fair or no discriminative ability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Carlos Zamora, Elisabet Canto, Silvia Vidal
Summary: Patients with chronic inflammatory diseases often have cardiovascular risks due to persistent systemic inflammation and endothelial activation. Activated platelets are considered major players in this inflammation, although their role has become controversial in recent years. Platelets can release both pro- and anti-inflammatory mediators and modulate the function of circulating lymphocytes, monocytes, and neutrophils, but how they exert this dual role is not fully understood.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Adam Corken, Sanchita P. Ghosh, Ruofei Du, Marjan Boerma, Jerry Ware, Rupak Pathak
Summary: The study revealed that the lack of functional platelet GPIb alpha enhances radiation toxicity, leading to higher radiation lethality and more severe inflammatory response, as well as exacerbating intestinal damage. These findings suggest that GPIb alpha-mediated interactions play a crucial role in limiting radiation injury.
RADIOTHERAPY AND ONCOLOGY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Rodrigo J. Gonzalez, Ulrich H. von Andrian
Summary: The interaction between GPR35 receptor and 5-HIAA serotonin metabolite promotes the recruitment of neutrophils from blood into inflamed tissues, which is significant for inflammation and anti-microbial host defense.
Article
Multidisciplinary Sciences
Jesus H. Dominguez, Danhui Xie, K. J. Kelly
Summary: Despite advances in understanding the pathophysiology and supportive care of acute kidney injury (AKI), mortality in AKI patients remains high. Research has shown that inflammation and microvascular dysfunction occur not only in the kidney, but also in remote organs after renal ischemia. Using intravital multiphoton fluorescence imaging in a rat model, abnormalities in microvascular flow were observed in all evaluated organs. Treatment with the platelet aggregation inhibitor dipyridamole significantly improved microvascular plasma flow and microthrombi. These findings have relevance to human AKI.
Article
Immunology
Amro M. Soliman, Taekwan Yoon, Jiahui Wang, James L. Stafford, Daniel R. Barreda
Summary: The study investigates the kinetics of leukocyte recruitment in fish skin infections, demonstrating early upregulation of inflammatory cytokines and migration of neutrophils to the injury site. Resolution of inflammation is marked by reduction in reactive oxygen species and pro-inflammatory cytokines expression.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Poppy Nathan, Julie Elizabeth Gibbs, G. Ed Rainger, Myriam Chimen
Summary: As individuals age, there is dysregulation of leukocyte trafficking and decreased circadian outputs. The relationship between age-related circadian changes and the development of immune-mediated inflammatory disorders (IMIDs) requires further investigation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Allergy
Gopinath Kasetty, Ravi K. V. Bhongir, Praveen Papareddy, Ellen Tufvesson, Henning Stenberg, Leif Bjermer, Anna Hultgardh-Nilsson, Heiko Herwald, Arne Egesten
Article
Biochemistry & Molecular Biology
Ellinor Kenne, Joel Rasmuson, Thomas Renne, Monica L. Vieira, Werner Mueller-Esterl, Heiko Herwald, Lennart Lindbom
Article
Immunology
Monica L. Vieira, Sandra Persson, Monica Lopes-Ferreira, Eliete C. Romero, Karin Kirchgatter, Ana Lucia T. O. Nascimento, Heiko Herwald
JOURNAL OF INFECTIOUS DISEASES
(2019)
Article
Immunology
Sandra T. Persson, Simon Ekstrom, Praveen Papareddy, Heiko Herwald
JOURNAL OF INNATE IMMUNITY
(2020)
Article
Microbiology
Praveen Papareddy, Madlen Rossnagel, Femke Doreen Hollwedel, Gulcan Kilic, Srinivas Veerla, Clement Naudin, Emanuel Smeds, Johannes Westman, Irene Martinez-Martinez, Arne Egesten, Maria Eugenia de la Morena-Barrio, Javier Corral, Adam Linder, Andrea Artoni, Maria Abbattista, Cristina Novembrino, Cord Herbert Brakebusch, Ida Martinelli, Gopinath Kasetty, Heiko Herwald
NATURE MICROBIOLOGY
(2019)
Review
Microbiology
Monica L. Vieira, Heiko Herwald, Ana Lucia T. O. Nascimento
CRITICAL REVIEWS IN MICROBIOLOGY
(2020)
Article
Immunology
Jon Olinder, Daniel Ehinger, Erik Liljenborg, Heiko Herwald, Cecilia Ryden
JOURNAL OF INNATE IMMUNITY
(2020)
Article
Multidisciplinary Sciences
Mohammed Yousif Merza, Rundk Ahmed Hwaiz, Badraldin Kareem Hamad, Karzan Abdulmuhsin Mohammad, Harmand Ali Hama, Abdulkarim Yasin Karim
Summary: This study aimed to evaluate serum cytokines in COVID-19 patients. The results indicated that IL-6 levels were significantly higher in moderate and severe COVID-19 groups, while IL-4 and IFN-gamma levels were significantly lower in the recovery group, and IL-10 levels were significantly higher in recovered COVID-19 patients.
Article
Gastroenterology & Hepatology
Martina Sjobeck, Hanna Sternby, Heiko Herwald, Henrik Thorlacius, Sara Regner
Summary: HBP levels are significantly increased in patients with acute pancreatitis, surpassing levels reported in other conditions. However, in this study, no significant correlation was found between HBP levels and disease severity or the need for intravenous fluid. Further studies on HBP are necessary to explore its role in the pathogenesis of acute pancreatitis and its clinical implications.
BMC GASTROENTEROLOGY
(2021)
Article
Immunology
Rundk Hwaiz, Mohammed Merza, Badraldin Hamad, Shirin HamaSalih, Mustafa Mohammed, Harmand Hama
Summary: The majority of patients with SARS-CoV-2 show abnormal hepatic enzyme activities, which may be related to virus replication in the liver.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Hilger Jagau, Swathi Packirisamy, Kyle Brandon, Heiko Herwald
Summary: Recognition and elimination of invading pathogens by the innate immune system is crucial in preventing systemic complications from infection. Streptococcus pyogenes can shield its outer surface with plasma proteins to protect itself from lytic attacks, allowing the bacteria to adjust gene regulation in response to a hostile environment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Jon Olinder, Alex Borjesson, Jakob Norrman, Tobias West, Joakim Carlstrom, Alexander Gustafsson, Martin Annborn, Heiko Herwald, Cecilia Ryden
Summary: This study investigated the relevance of hepcidin as a diagnostic and prognostic tool for sepsis. The results showed that hepcidin levels can be used to differentiate sepsis and have predictive value for mortality in patients admitted to the intensive care unit.
SCIENTIFIC REPORTS
(2022)
Article
Critical Care Medicine
Gabriel Jakobsson, Praveen Papareddy, Henrik Andersson, Megan Mulholland, Ravi Bhongir, Irena Ljungcrantz, Daniel Engelbertsen, Harry Bjorkbacka, Jan Nilsson, Adrian Manea, Heiko Herwald, Marisol Ruiz-Meana, Antonio Rodriguez-Sinovas, Michelle Chew, Alexandru Schiopu
Summary: This study revealed the association between elevated plasma S100A8/A9 levels and left ventricle dysfunction in severe sepsis patients, and demonstrated the potential therapeutic effects of pharmacological blockade of S100A8/A9 in mitigating myocardial dysfunction.
Article
Immunology
Rundk Ahmad Hwaiz, Sahar Mohammed Zaki Abdullah, Salah Tofik Jalal Balaky, Katan Sabir Ali, Mohammed Yousif Merza, Shakhawan Assad Khailani, Nazar Pauls Shabila
Summary: This study aimed to describe and analyze the clinical and hematological characteristics of 300 hospitalized COVID-19 patients in Erbil, Kurdistan. The findings showed that different factors such as age, diabetes mellitus, and chronic disease were significantly associated with death among COVID-19 patients. Additionally, there were differences in hematological and biochemical parameters between recovered and deceased patients.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2022)
Editorial Material
Immunology
Heiko Herwald, Arne Egesten
JOURNAL OF INNATE IMMUNITY
(2020)