Journal
ACTA PSYCHIATRICA SCANDINAVICA
Volume 138, Issue 6, Pages 591-604Publisher
WILEY
DOI: 10.1111/acps.12961
Keywords
schizophrenia; psychosis; cognition; cognitive impairment
Categories
Funding
- Graduates School of Medical Science, University Medical Center Groningen, The Netherlands
- Geestkracht programme of the Dutch Health Research Council (Zon-Mw) [10-000-1001]
- Lundbeck
- AstraZeneca
- Eli Lilly
- Janssen Cilag
- Amsterdam: Academic Psychiatric Centre of the Academic Medical Center
- GGZ Ingeest
- Arkin
- Dijk en Duin
- GGZ Rivierduinen
- Erasmus Medical Centre
- GGZ Noord Holland Noord
- Groningen: University Medical Center Groningen
- GGZ Friesland
- GGZ Drenthe
- Dimence
- Mediant
- GGNet Warnsveld
- Yulius Dordrecht
- Parnassia psycho-medical center The Hague
- Maastricht: Maastricht University Medical Centre
- GGZ Eindhoven en De Kempen
- GGZ Breburg
- GGZ Oost-Brabant
- Vincent van Gogh voor Geestelijke Gezondheid
- Mondriaan
- Virenze riagg
- Zuyderland GGZ
- MET ggz
- Universitair Centrum Sint-Jozef Kortenberg
- CAPRI University of Antwerp
- PC Ziekeren Sint-Truiden
- PZ Sancta Maria Sint-Truiden
- GGZ Overpelt
- OPZ Rekem
- Utrecht: University Medical Center Utrecht
- Altrecht
- GGZ Centraal
- Delta
- Lentis
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Objective Method This study aimed to assess the heterogeneity and stability of cognition in patients with a non-affective psychotic disorder and their unaffected siblings. In addition, we aimed to predict the cognitive subtypes of siblings by their probands. Assessments were conducted at baseline, 3 and 6 years in 1119 patients, 1059 siblings and 586 controls from the Genetic Risk and Outcome of Psychosis (GROUP) study. Group-based trajectory modeling was applied to identify trajectories and clustered multinomial logistic regression analysis was used for prediction modeling. A composite score of eight neurocognitive tests was used to measure cognitive performance. Results Conclusions Five stable cognitive trajectories ranging from severely altered to high cognitive performance were identified in patients. Likewise, four stable trajectories ranging from moderately altered to high performance were found in siblings. Siblings had a higher risk of cognitive alteration when patients' alteration was mild (OR = 2.21), moderate (OR = 5.70), and severe (OR = 10.07) compared with patients with intact cognitive function. The familial correlation coefficient between pairs of index patients and their siblings was 0.27 (P = 0.003). The cognitive profiles identified in the current study might be suitable as endophenotypes and could be used in future genetic studies and predicting functional and clinical outcomes.
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