Review
Psychiatry
Tyler B. Mason, Elin Lantz Lesser, Anna R. Dolgon-Krutolow, Stephen A. Wonderlich, Kathryn E. Smith
Summary: Existing data suggests deficits in social cognitive functioning are observed across different forms of psychopathology, with a focus on eating disorders such as anorexia nervosa. Studies indicate some deficiencies in social cognition in EDs, particularly in anorexia nervosa. However, research on bulimia nervosa and binge eating disorder is limited and inconsistent, warranting further investigation.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Review
Clinical Neurology
Michele Fornaro, Anna Maria Mondin, Martina Billeci, Andrea Fusco, Michele De Prisco, Claudio Caiazza, Fausta Micanti, Raffaella Calati, Andre Ferrer Carvalho, Andrea de Bartolomeis
Summary: This study conducted a systematic review and meta-analysis on the weight and affective psychopathology outcomes of major eating disorders. The results showed that different drugs have varying efficacy in different eating disorders, suggesting the need for further research.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Nutrition & Dietetics
Lisa Brelet, Valentin Flaudias, Michel Desert, Sebastien Guillaume, Pierre-Michel Llorca, Yves Boirie
Summary: Research on stigmatization in eating disorders has shown that individuals with anorexia nervosa, bulimia nervosa, and binge eating disorder face stereotypes, prejudices, and discrimination, which are influenced by demographic factors like age, gender, and income level. This stigma has negative effects on individuals' eating disorders, psychological wellbeing, and treatment-seeking behavior, highlighting the need for further research and prevention efforts.
Review
Psychiatry
Anna Herman, Armand Bajaka
Summary: Binge eating disorder and bulimia nervosa are eating disorders characterized by episodes of overeating, and research suggests a relationship between these disorders and dysbiosis of the intestinal microbiota, indicating potential for treatment by targeting the gut microbiota.
PSYCHIATRY RESEARCH
(2021)
Review
Psychology, Multidisciplinary
Mario Miniati, Francesca Marzetti, Laura Palagini, Donatella Marazziti, Graziella Orru, Ciro Conversano, Angelo Gemignani
Summary: The COVID-19 pandemic may exacerbate or trigger eating disorders, with changes in physical activity routines, food access limitations, restricted healthcare facilities, social isolation, and conflicts in relationships all contributing to worsening symptoms in predisposed individuals. These findings highlight the negative impact of COVID-19 on eating disorders and related quality of life.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Psychology, Developmental
Alexandra D. Convertino, Aaron J. Blashill
Summary: This study found high rates of comorbid psychiatric disorders in 9-10 year old children with eating disorders, particularly anxiety, attention deficit/hyperactivity disorder, and mood disorders. Clinicians should be aware of the possibility of eating disorders in this age group and the associated severe comorbidity, considering referrals for specialty mental health care.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2022)
Article
Psychology, Clinical
Pamela K. Keel, Lisa A. Eckel, Britny A. Hildebrandt, Alissa A. Haedt-Matt, Daryl J. Murry, Jonathan Appelbaum, David C. Jimerson
Summary: This study found a specific association between delayed gastric emptying and purging behaviors, but correcting disruptions in gastric emptying may exacerbate disruptions in gut peptide responses specifically linked to the presence of purging after normal amounts of food.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Georg Halbeisen, Karsten Braks, Thomas J. Huber, Georgios Paslakis
Summary: This study found that in the same treatment setting, male patients with anorexia showed significant improvements in symptoms, while male patients with BED experienced greater weight loss during treatment. For other eating disorders, the treatment outcomes between men and women were generally similar.
Article
Nutrition & Dietetics
Carlos Eduardo Ferreira de Moraes, Marina Maria Leite Antunes, Carla Mourilhe, Rosely Sichieri, Phillipa Hay, Jose Carlos Appolinario
Summary: A study in a metropolitan city in Brazil found that individuals with BESC exhibited different eating patterns. BED and RBE participants consumed staple foods more frequently, while those with BN preferred high calorie foods.
Review
Clinical Neurology
Joseph A. Wonderlich, Mariya Bershad, Joanna E. Steinglass
Summary: Studies using fMRI have shown that cognitive control systems are affected in individuals with eating disorders, with the least pronounced effects seen in AN. The reinforcing value of food may be reduced in AN, but individuals with BN and BED show hyperactivation to rewarding food-related stimuli. These findings provide insight into potential neurobiological mechanisms underlying eating disorders.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Article
Psychiatry
Margaret Sala, Ani Keshishian, Sarah Song, Rivka Moskowitz, Cynthia M. Bulik, Corey R. Roos, Cheri A. Levinson
Summary: In this meta-analysis of 35 papers, we found that receiving a higher level of care, having psychiatric comorbidity, and higher severity of ED psychopathology were associated with a higher likelihood of relapse in eating disorders. Conversely, higher leptin levels, higher meal energy density/variety, higher motivation for change, higher body mass index/weight/body fat, better response to treatment, anorexia nervosa-restricting subtype diagnosis, and older age of ED onset were associated with a lower likelihood of relapse. Various moderators were also identified.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychiatry
Brad A. MacNeil, Sydney Thib
Summary: This study investigated the use of psychiatric medication among Canadian adults with eating disorders prior to specialized outpatient care. The research found that a significant number of adults had been prescribed psychiatric medication, with antidepressants and anti-anxiety medications being the most commonly used.
PSYCHIATRY RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Jacopo Pruccoli, Antonia Parmeggiani, Duccio Maria Cordelli, Marcello Lanari
Summary: Noradrenaline plays a role in modulating feeding behavior and satiety, with conflicting evidence in its relationship with Eating Disorders (EDs). Preclinical studies suggest involvement of noradrenergic pathways in binge-like behaviors, while genetic and clinical studies show inconsistent findings on the absolute alterations in plasma NE values in patients with EDs. Pharmacological studies support the efficacy of noradrenaline-modulating therapies in treating EDs, but further research is needed to understand the potential of the noradrenergic system as a target for treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Psychiatry
Phillipa Hay, Deborah Mitchison
Summary: The association between urbanization and eating disorders is complex, with urbanization mainly having indirect effects on eating behavior. Recent studies suggest an increase in eating disorders in Africa and Asia, but most research only includes adolescents and young women. Further research is needed to investigate moderating and mediating effects in more diverse populations.
CURRENT OPINION IN PSYCHIATRY
(2021)
Article
Psychology, Clinical
Ann F. Haynos, Shirley B. Wang, Sarah Lipson, Carol B. Peterson, James E. Mitchell, Katherine A. Halmi, W. Stewart Agras, Scott J. Crow
Summary: This study compared machine learning (ML) with traditional regression for predicting eating disorder (ED) outcomes, finding that ML models had higher accuracy in predicting all outcomes over 2 years. Important predictors included baseline ED, psychiatric, and demographic characteristics.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Psychology, Clinical
I Krug, J. Linardon, C. Greenwood, G. Youssef, J. Treasure, F. Fernandez-Aranda, A. Karwautz, G. Wagner, D. Collier, M. Anderluh, K. Tchanturia, V Ricca, S. Sorbi, B. Nacmias, L. Bellodi, M. Fuller-Tyszkiewicz
Summary: This study compared traditional logistic regression models with two machine learning approaches to predict eating disorder onset and differential diagnoses. The results showed that all three approaches had satisfactory predictive accuracy, with the machine learning methods producing more parsimonious models. The study also found that different risk factors varied depending on the specific eating disorder classification.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Jenny Yiend, Charlene L. M. Lam, Nora Schmidt, Bryony Crane, Margaret Heslin, Thomas Kabir, Philip McGuire, Christopher Meek, Elias Mouchlianitis, Emmanuelle Peters, Daniel Stahl, Antonella Trotta, Sukhwinder Shergill
Summary: This study investigated the feasibility and efficacy of Cognitive Bias Modification for paranoia (CBM-pa) in patients with paranoia. The results showed that CBM-pa was effective in reducing interpretation bias, improving paranoia symptoms, and reducing levels of depressed and anxious mood. The study provides a foundation for conducting a fully powered randomized controlled trial.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Antonis C. Zamar, Christos Kouimtsidis, Abbi Lulsegged, Robin Roberts, Theodoros Koutsomitros, Daniel Stahl
Summary: This study investigated the effectiveness of the combined treatment of high-dose levothyroxine (HDT) and repetitive transcranial magnetic stimulation (rTMS) for rapid cycling bipolar spectrum disorders (BSD). The results showed significant improvement in symptoms, with most patients achieving remission and long-term improvement in quality of life.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Psychiatry
Chloe Hutchings-Hay, Marcela M. Dapelo, Gisselle Briceno, Camila Fernandez, Kate Tchanturia
Summary: This study examined how facial expressions and bodily postures interact to influence emotional experiences. The results showed that having positive facial expression and body posture together enhanced positive affect.
Article
Psychiatry
Sophie E. Smart, Deborah Agbedjro, Antonio F. Pardinas, Olesya Ajnakina, Luis Alameda, Ole A. Andreassen, Thomas R. E. Barnes, Domenico Berardi, Sara Camporesi, Martine Cleusix, Philippe Conus, Benedicto Crespo-Facorro, Giuseppe D'Andrea, Arsime Demjaha, Marta Di Forti, Kim Do, Gillian Doody, Chin B. Eap, Aziz Ferchiou, Lorenzo Guidi, Lina Homman, Raoul Jenni, Eileen Joyce, Laura Kassoumeri, Ornella Lastrina, Ingrid Melle, Craig Morgan, Francis A. O'Neill, Baptiste Pignon, Romeo Restellini, Jean-Romain Richard, Carmen Simonsen, Filip Spaniel, Andrei Szoke, Ilaria Tarricone, Andrea Tortelli, Alp Ucok, Javier Vazquez-Bourgon, Robin M. Murray, James T. R. Walters, Daniel Stahl, James H. MacCabe
Summary: This study aimed to identify characteristics at the first-episode of psychosis that are associated with later antipsychotic treatment resistance (TR) and develop a parsimonious prediction model for TR. The findings suggest that younger age of psychosis onset and fewer years in education are independently associated with an increased risk of developing TR.
SCHIZOPHRENIA RESEARCH
(2022)
Correction
Endocrinology & Metabolism
Rebecca Upsher, Dulce Alarcon-Yaquetto, Daniel Stahl, Khalida Ismail, Kirsty Winkley
PRIMARY CARE DIABETES
(2023)
Article
Psychology, Clinical
Johanna Louise Keeler, Georgia Peters-Gill, Janet Treasure, Hubertus Himmerich, Kate Tchanturia, Valentina Cardi
Summary: This study suggests that individuals with anorexia nervosa have difficulties in recalling specific details of autobiographical memory and generating positive episodic future thoughts. These difficulties may contribute to a negative bias on their view of the future and lessen hope for recovery.
JOURNAL OF EATING DISORDERS
(2022)
Article
Computer Science, Information Systems
Diana Shamsutdinova, Jayati Das-Munshi, Mark Ashworth, Angus Roberts, Daniel Stahl
Summary: The study aimed to develop and internally validate a T2DM prevalence model for people with severe mental illness (SMI). Logistic regression and XGBoost models performed well in detecting T2DM presence in SMI patients. Age and ethnicity were the most important predictors. The predicted 2.14% increase in T2DM prevalence in the East London SMI population in 20 years indicates the impact of projected demographic changes.
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
(2023)
Article
Clinical Neurology
Lucy A. Chester, Lucia R. Valmaggia, Matthew J. Kempton, Edward Chesney, Dominic Oliver, Emily P. Hedges, Elise Klatsa, Daniel Stahl, Mark van der Gaag, Lieuwe de Haan, Barnaby Nelson, Patrick McGorry, G. Paul Amminger, Anita Riecher-Rossler, Erich Studerus, Rodrigo Bressan, Neus Barrantes-Vidal, Marie-Odile Krebs, Birte Glenthoj, Merete Nordentoft, Stephan Ruhrmann, Gabriele Sachs, Philip McGuire
Summary: The aim of this study was to investigate the association between cannabis use and the incidence of psychotic disorders in individuals at clinical high risk of psychosis. The results showed no significant association between cannabis use and the transition to psychosis, persistence of symptoms, or functional outcome.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Review
Psychology, Clinical
Emily Davey, Karina Allen, Sophie D. D. Bennett, Rachel Bryant-Waugh, Tim Clarke, Zafra Cooper, Katharina Dixon-Ward, Jake Dudley, Ivan Eisler, Jess Griffiths, Andrew J. J. Hill, Nadia Micali, Rebecca Murphy, Ivana Picek, Ros Rea, Ulrike Schmidt, Mima Simic, Kate Tchanturia, Gemma Traviss-Turner, Janet Treasure, Hannah Turner, Tracey Wade, Glenn Waller, Roz Shafran
Summary: In October 2022, a group of predominantly UK-based clinical and academic researchers, charity representatives, and people with lived experience convened to discuss ways to improve access to and efficacy of programme-led and focused interventions for eating disorders, in an attempt to bridge the demand-capacity gap.
EUROPEAN EATING DISORDERS REVIEW
(2023)
Article
Cardiac & Cardiovascular Systems
Robert Aldous, Roman Roy, Antonio Cannata, Muhamad Abdrazak, Shamika Mohanan, Nicholas Beckley-Hoelscher, Daniel Stahl, Ritesh Kanyal, Peter Kordis, Nicholas Sunderland, Aleksandra Parczewska, Ali Kirresh, Joanne Nevett, Rachael Fothergill, Ian Webb, Rafal Dworakowski, Narbeh Melikian, Sundeep Kalra, Thomas W. Johnson, Gianfranco Sinagra, Serena Rakar, Marko Noc, Sameer Patel, Georg Auzinger, Marcin Gruchala, Ajay M. Shah, Jonathan Byrne, Philip MacCarthy, Nilesh Pareek
Summary: This study compared the discrimination performance of the MIRACLE2 score, downtime, and current randomized controlled trial (RCT) recruitment criteria in predicting poor neurologic outcome after out-of-hospital cardiac arrest (OHCA). The results showed that the MIRACLE2 score had a stronger association with outcome and higher discrimination for poor outcome compared to downtime and RCT recruitment criteria. The potential for the MIRACLE2 score to improve the selection of OHCA patients should be evaluated in future RCTs.
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Genetics & Heredity
Diana Shamsutdinova, Olesya Ajnakina, Angus Roberts, Daniel Stahl
Summary: This study investigated the association between polygenic risk of schizophrenia and the onset of type 2 diabetes (T2DM). The results suggest a low contribution of schizophrenia polygenic risk to future T2DM onset.
PSYCHIATRIC GENETICS
(2023)
Article
Health Care Sciences & Services
Andy Zamar, Ashma Mohamed, Abbi Lulsegged, Daniel Stahl, Christos Kouimtsidis
Summary: Diagnosing bipolar spectrum disorder is challenging, and there are significant delays in diagnosis in both the UK and the USA. We have investigated the use of biomarkers as a potential diagnostic test, and found three mutations with high sensitivity and specificity in distinguishing bipolar spectrum disorders from recurrent depressive disorder. These biomarkers have the potential to provide a more objective and accurate diagnosis, even in severely unwell patients.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Psychiatry
Rayan Taher, Che-Wei Hsu, Chloe Hampshire, Carolina Fialho, Clare Heaysman, Daniel Stahl, Sukhi Shergill, Jenny Yiend
Summary: This study aims to assess the safety of digital mental health interventions (DMHIs) by reviewing the literature. It found that there is significant variation in the methods and frequency of safety assessments for DMHIs in both the research and postmarket phases. The main reported adverse event in treatment was symptom deterioration, and exclusion of high-risk groups was the main method used to mitigate risk.
JMIR MENTAL HEALTH
(2023)
Article
Psychology, Clinical
J. Webb, N. Dhopatkar, P. Croft, H. Himmerich, C. Baillie, L. Dodwell, K. Tchanturia
Summary: Avoidant Restrictive Food Intake Disorder (ARFID) is a serious eating disorder with little research on best practices, especially among adults. When ARFID coexists with autism, treatment options become further complicated. This case study discusses the treatment of an autistic woman with ARFID in an inpatient eating disorder setting. Food exposure and trials were used to increase food variety and nutrition, leading to promising results in weight and food repertoire improvement. Although results may not apply to a wider population, this approach could be beneficial for individuals with ARFID and autism.
CLINICAL CASE STUDIES
(2023)
