Article
Environmental Sciences
Tran Thi Thanh Hue, Qiuda Zheng, Nguyen Thi Kieu Anh, Vu Ngan Binh, Ngo Quang Trung, Hoang Thu Trang, Pham Quoc Chinh, Luu Quang Minh, Phong K. Thai
Summary: Illicit drug use is a significant issue in Vietnam, but there is limited information available. This study utilized wastewater-based epidemiology to assess the prevalence of illicit drug use in an urban population of Vietnam. The findings reveal that methamphetamine has become the most commonly used drug, surpassing heroin.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biology
Carlos Isaza, Oscar Mauricio Castano-Ramirez, Juan Pablo Velez, Julieta Henao, Leonardo Beltran-Angarita, Juan Carlos Sepulveda-Arias
Summary: Compared to conventional methadone maintenance treatment, using the CYP2B6 516G>T polymorphism to calculate methadone dosage resulted in improved retention rates, reduced heroin usage, and improved quality of life for patients.
Article
Health Care Sciences & Services
Kuan-Cheng Chang, Ke-Wei Chen, Chieh-Liang Huang, Wen-Ling Liao, Mei-Yao Wu, Yu-Kai Lin, Yi-Tzone Shiao, Wei-Hsin Chung, Yen-Nien Lin, Hsien-Yuan Lane
Summary: Carriers of the NOS1AP rs164148 AA genotype variant in men receiving methadone treatment have a shorter QTc interval. This genetic polymorphism attenuates the QTc-prolonging effect of methadone, potentially explaining the unpredictable and heterogeneous risks for severe QTc prolongation and sudden cardiac death in methadone patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Laura Santin, Giuseppe Verlato, Ahmad Tfaily, Roberto Manera, Giuseppe Zinfollino, Francesca Fusina, Fabio Lugoboni
Summary: This study assessed the effect of methadone on the QTc interval and investigated the benefits of Levomethadone. Results showed a linear association between methadone dosage and QTc length, and no correlation between QTc value and gender, age, or therapy duration. The study confirmed the role of methadone in QTc prolongation and validated the efficiency of Levomethadone as a therapeutic substitute, highlighting the importance of electrocardiographic monitoring in methadone-treated patients.
Article
Obstetrics & Gynecology
Shree Sundaresh, Gouri B. Sadananda, Jennifer L. Bailit
Summary: The severity of opioid use disorder during pregnancy did not change over time, according to this study. However, there was an increase in women reporting high-dose use and a preference for buprenorphine. Additionally, the rate of full-term deliveries also increased.
JOURNAL OF PERINATOLOGY
(2022)
Article
Obstetrics & Gynecology
Dominique Bulgin, Stephen W. W. Patrick, Tamarra McElroy, Elizabeth McNeer, William D. D. Dupont, Velma McBride Murry
Summary: This study aims to examine the factors that affect access to treatment for women with opioid use disorder, including race and ethnicity, community characteristics, and pregnancy status. The analysis of secondary data from a simulated patient caller study in 10 U.S. states reveals that community race and ethnicity distribution and clinic type are associated with the likelihood of securing an appointment for treatment.
OBSTETRICS AND GYNECOLOGY
(2023)
Article
Medical Laboratory Technology
Xiaohu Xie, Jun Gu, Dingding Zhuang, Yun Zhou, Xiaoyu Chen, Wenwen Shen, Longhui Li, Yue Liu, Wenjin Xu, Qingxiao Hong, Zemin Xu, Weisheng Chen, Wenhua Zhou, Huifen Liu
Summary: This study suggests that the rs1799971 polymorphism in the OPRM1 gene may not be associated with response or dose requirement in methadone maintenance treatment in the Han Chinese population.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Psychology, Clinical
Lei Wang, Feng Hu, Wei Li, Qiang Li, Yongbin Li, Jia Zhu, Xuan Wei, Jian Yang, Jianxin Guo, Yue Qin, Hong Shi, Wei Wang, Yarong Wang
Summary: This study aimed to construct addiction-related brain networks for heroin dependent patients undergoing methadone maintenance treatment (MMT) and identify high-risk individuals for relapse. The study found that MMT patients can be classified into two subgroups with significantly different relapse rates based on distinct brain-network patterns. The group with high-relapse had wider DC changes in the cortical-striatal-thalamic circuit and reduced DC in the mesocorticolimbic circuit compared to the low-relapse group. DC activity in NAc, vACC, hippocampus and amygdala were closely related to relapse.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Joshua G. Berenbaum, Prianca A. Nadkarni, Cherie L. Marvel
Summary: This study used functional magnetic resonance imaging to examine the neural mechanisms involved in working memory in opioid-dependent individuals. The results showed that the opioid-dependent group had slower response time and differences in brain activity compared to the healthy controls. Understanding these neural differences can shed light on the impact of substance use on the brain and cognition, potentially leading to new therapeutic targets for substance use disorder.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Qian Lv, Miao Zhang, Haifeng Jiang, Yilin Liu, Shaoling Zhao, Xiaomin Xu, Wenlei Zhang, Tianzhen Chen, Hang Su, Jiangtao Zhang, Heqiu Wang, Jianmin Zhang, Yuanjing Feng, Yongqiang Li, Biao Li, Min Zhao, Zheng Wang
Summary: Elevated impulsivity is commonly observed in individuals receiving methadone maintenance therapy (MMT) for opioid addiction. This study aimed to understand the underlying neural mechanisms and cognitive subprocesses associated with this impulsivity. The results showed that individuals receiving MMT exhibited higher self-reported impulsivity and had a tendency for impulsive decision-making without available evidence. The impulsive decision bias was associated with the dose and duration of methadone use, rather than the duration of heroin use. Furthermore, the hypoactivation in the left rostral middle frontal gyrus during a decision-making task was correlated with the impulsive decision bias. The findings suggest that elevated impulsivity in individuals receiving MMT is driven by deficits in top-down cognitive control, rather than reward sensitivity.
Article
Psychology, Clinical
Stephanie Paula Elisabeth Guillery, Rainer Hellweg, Soeren Enge, Ulrich Bohr, Hagen Kunte, Golo Kronenberg
Summary: A survey study was conducted from February to June 2018 on outpatients receiving diamorphine or methadone/levomethadone maintenance treatment, highlighting the higher satisfaction levels of diamorphine patients with their substitute drug and reductions in relapse-related behaviors and cravings.
INTERNATIONAL JOURNAL OF MENTAL HEALTH AND ADDICTION
(2021)
Article
Multidisciplinary Sciences
Lauren A. Paul, Ye Li, Pamela Leece, Tara Gomes, Ahmed M. Bayoumi, Jeremy Herring, Regan Murray, Patrick Brown
Summary: The study found that opioid-related mortality in Ontario, Canada is on the rise, especially among younger individuals. The research models estimate that opioid-related mortality among the younger population will continue to grow, with male mortality rates potentially more than quadruple those of pre-pandemic estimations.
Article
Biochemistry & Molecular Biology
Stephanie A. Carmack, Janaina C. M. Vendruscolo, M. Adrienne McGinn, Jorge Miranda-Barrientos, Vez Repunte-Canonigo, Gabriel D. Bosse, Daniele Mercatelli, Federico M. Giorgi, Yu Fu, Anthony J. Hinrich, Francine M. Jodelka, Karen Ling, Robert O. Messing, Randall T. Peterson, Frank Rigo, Scott Edwards, Pietro P. Sanna, Marisela Morales, Michelle L. Hastings, George F. Koob, Leandro F. Vendruscolo
Summary: This study explores the mechanistic role of extrahypothalamic stress systems in driving opioid addiction and finds that glucocorticoid receptor antagonism with mifepristone reduces opioid addiction-like behaviors and decreases the firing of corticotropin-releasing factor neurons in the rat amygdala.
MOLECULAR PSYCHIATRY
(2022)
Article
Psychiatry
Wenhui Li, Jin Huang, Nan Zhang, Kathrin Weidacker, Jun Li, Valerie Voon, Chuansheng Wang, Chencheng Zhang
Summary: The present study investigates whether patients with opioid use disorder on chronic methadone maintenance therapy exhibit abnormal attentional bias to drug and negative-affective cues. The results show that these patients have normalized attentional bias to both types of cues. Furthermore, the duration of methadone treatment and impulsivity level were found to affect the attentional avoidance of negative-affective cues in patients.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Jingchen Li, Guoqiang Song, Qianxu Jin, Liqiang Liu, Liang Yang, Yuanyu Wang, Xuesong Zhang, Zongmao Zhao
Summary: Cacna2d1 knockout alleviates cerebral hematoma in ICH mice, reduces neuronal apoptosis and inflammation, and restores nerve functions. Loss of Cacna2d1 may provide therapeutic clues for ICH treatment.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)
