Journal
INORGANICA CHIMICA ACTA
Volume 433, Issue -, Pages 26-34Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ica.2015.04.033
Keywords
Copper (II) complexes; DNA binding; DNA cleavage; Molecular docking studies; Antimicrobial and cytotoxicity
Categories
Funding
- VIT University, Vellore, India
- VIT University
Ask authors/readers for more resources
A series of eight new copper (II) complexes of types [Cu(HL1)(B)] (4a-4d) and [Cu(HL2)(B)] (4e-4h), where HL1 is N-(2-hydroxy-1-naphthalidene)-2-aminophenol, HL2 is N-(2-hydroxy-1-naphthylidene)-2- mercaptoaniline and B is N, N donor ligands viz bipyridyl (bpy), 1,10-phenanthroline (phen), dipyridoquinoxaline (dpq) and dipyridophenazine (dppz) have been synthesized and characterized by elemental analysis as well as by spectroscopic techniques (IR, UV, ESI mass and EPR spectra). The DNA-binding properties of these copper complexes (4a-4h) have been investigated by electronic absorption, viscosity measurements and docking analyses. The results obtained indicated that the complexes get bonded with DNA via an intercalation binding mode with an intrinsic binding constant, K-b (1.116 +/- 0.21 to 7.227 +/- 0.21) x 10(4) M-1. The antimicrobial activity assays with the Schiff's bases and their heteroleptic copper (II) complexes of 4a and 4b exhibited profound activity against gram positive bacteria, gram negative bacteria and fungi. Further, complexes 4d and 4h displayed significant cytotoxicity when examined in vitro on a panel of cancerous cell line - human liver cancer cell line - HepG-2 cells (IC50 = 40.82 and 29.74 lg/ml). (C) 2015 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available