Hypoxia-inducible factor signalling mechanisms in the central nervous system

A role for prolyl hydroxylase domain proteins in hippocampal synaptic plasticity

(2013) Alan Corcoran et al.   HIPPOCAMPUS

Hypoxia-Inducible Factor 1 Protects Hypoxic Astrocytes against Glutamate Toxicity

(2012) Yomna Badawi et al.   ASN Neuro

Prolyl hydroxylase domain protein 2 regulates the intracellular cyclic AMP level in cardiomyocytes through its interaction with phosphodiesterase 4D

(2012) Zhaoxia Huo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

HIF-1  is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2 -induced excessive erythropoiesis

(2012) K. Franke et al.   BLOOD

Hypoxia regulates glutamate receptor trafficking through an HIF-independent mechanism

(2012) Eun Chan Park et al.   EMBO JOURNAL

Synaptic NMDA Receptors Mediate Hypoxic Excitotoxic Death

(2012) C. M. Wroge et al.   JOURNAL OF NEUROSCIENCE

Roles of individual prolyl-4-hydroxylase isoforms in the first 24 hours following transient focal cerebral ischaemia: insights from genetically modified mice

(2012) Ruo-Li Chen et al.   JOURNAL OF PHYSIOLOGY-LONDON

A screen for inducers of p21waf1/cip1 identifies HIF prolyl hydroxylase inhibitors as neuroprotective agents with antitumor properties

(2012) Thong C. Ma et al.   NEUROBIOLOGY OF DISEASE

Putative depolarisation-induced retrograde signalling accelerates the repeated hypoxic depression of excitatory synaptic transmission in area CA1 of rat hippocampus via group I metabotropic glutamate receptors

(2012) F. Nuritova et al.   NEUROSCIENCE

Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity

(2012) D. Lovatt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuron-Specific Prolyl-4-Hydroxylase Domain 2 Knockout Reduces Brain Injury After Transient Cerebral Ischemia

(2012) Reiner Kunze et al.   STROKE

Prolyl Hydroxylase Domain Protein 2 (PHD2) Mediates Oxygen-Induced Retinopathy in Neonatal Mice

(2011) Li-Juan Duan et al.   AMERICAN JOURNAL OF PATHOLOGY

Iron MediatesN-Methyl-d-aspartate Receptor-dependent Stimulation of Calcium-induced Pathways and Hippocampal Synaptic Plasticity

(2011) Pablo Muñoz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of prolyl hydroxylases by dimethyloxaloylglycine after stroke reduces ischemic brain injury and requires hypoxia inducible factor-1α

(2011) Molly E. Ogle et al.   NEUROBIOLOGY OF DISEASE

Hyperthermic preconditioning protects astrocytes from ischemia/reperfusion injury by up-regulation of HIF-1 alpha expression and binding activity

(2010) Fang Du et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Hydroxylase inhibition reduces synaptic transmission and protects against a glutamate-induced ischemia in the CA1 region of the rat hippocampus

(2010) L. Batti et al.   NEUROSCIENCE

Oxygen and Glucose Deprivation in an Organotypic Hippocampal Slice Model of the Developing Rat Brain: The Effects on N-Methyl-d-Aspartate Subunit Composition

(2009) Lisa Wise-Faberowski et al.   ANESTHESIA AND ANALGESIA

Therapeutic Manipulation of the HIF Hydroxylases

(2009) Simon Nagel et al.   ANTIOXIDANTS & REDOX SIGNALING

HIF Prolyl Hydroxylase Inhibitors Prevent Neuronal Death Induced by Mitochondrial Toxins: Therapeutic Implications for Huntington's Disease and Alzheimer's Disease

(2009) Zoya Niatsetskaya et al.   ANTIOXIDANTS & REDOX SIGNALING

Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

(2009) Massimiliano Mazzone et al.   CELL

Loss or Silencing of the PHD1 Prolyl Hydroxylase Protects Livers of Mice Against Ischemia/Reperfusion Injury

(2009) Martin Schneider et al.   GASTROENTEROLOGY

Inhibition of Prolyl Hydroxylase Protects against 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Neurotoxicity

(2009) Donna W. Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor necrosis factor-α impairs the recovery of synaptic transmission from hypoxia in rat hippocampal slices

(2009) Laura Batti et al.   JOURNAL OF NEUROIMMUNOLOGY

Prolyl Hydroxylase Inhibitors Depend on Extracellular Glucose and Hypoxia-Inducible Factor (HIF)-2  to Inhibit Cell Death Caused by Nerve Growth Factor (NGF) Deprivation: Evidence that HIF-2  Has a Role in NGF-Promoted Survival of Sympathetic Neurons

(2009) D. J. Lomb et al.   MOLECULAR PHARMACOLOGY

Early inhibition of HIF-1α with small interfering RNA reduces ischemic–reperfused brain injury in rats

(2009) Chunhua Chen et al.   NEUROBIOLOGY OF DISEASE

Early modifications in N-methyl-d-aspartate receptor subunit mRNA levels in an oxygen and glucose deprivation model using rat hippocampal brain slices

(2009) S. Dos-Anjos et al.   NEUROSCIENCE

Adenosine A1 receptor activation mediates NMDA receptor activity in a pertussis toxin-sensitive manner during normoxia but not anoxia in turtle cortical neurons

(2008) Matthew Edward Pamenter et al.   BRAIN RESEARCH

Adenosine A1 and A3 receptors protect astrocytes from hypoxic damage

(2008) Olga Björklund et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Preconditioning with cobalt chloride or desferrioxamine protects oligodendrocyte cell line (MO3.13) from tumor necrosis factor-α-mediated cell death

(2008) Song-yi Yao et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Abnormal Sympathoadrenal Development and Systemic Hypotension in PHD3-/- Mice

(2008) T. Bishop et al.   MOLECULAR AND CELLULAR BIOLOGY

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

(2008) Julián Aragonés et al.   NATURE GENETICS

Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure

(2007) Y. A. Minamishima et al.   BLOOD

Nitric oxide deficit in chronic intermittent hypoxia impairs large conductance calcium-activated potassium channel activity in rat hippocampal neurons

(2007) Yung-Wui Tjong et al.   FREE RADICAL BIOLOGY AND MEDICINE