Article
Biochemistry & Molecular Biology
Baojun Sun, Hitomi Maruta, Yun Ma, Hiromi Yamashita
Summary: Taurine is an abundant free amino acid in mammalian tissues that plays a role in skeletal muscle function and exercise capacity. This study investigated the mechanism of taurine function in skeletal muscles by examining the effects of short-term administration of taurine on rats and L6 cells. The results suggest that taurine modulates skeletal muscle function by activating AMP-activated protein kinase through the calcium signaling pathway, leading to the expression of genes and proteins associated with mitochondrial and respiratory metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Yanjuan Hou, Qian Wang, Baosheng Han, Yiliang Chen, Xi Qiao, Lihua Wang
Summary: In diabetic nephropathy, CD36 mediates ROS production that enhances NLRP3 inflammasome activation, leading to IL-1 beta secretion and cell apoptosis. Inhibition of CD36 protects mice from tubulointerstitial inflammation and tubular epithelial cell apoptosis.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Antoine H. Chaanine, LeeAnn Higgins, Todd Markowski, Jarrod Harman, Maureen Kachman, Charles Burant, L. Gabriel Navar, David Busija, Patrice Delafontaine
Summary: Metabolic remodeling plays a significant role in the pathophysiology of heart failure, and the crosstalk between PKA and AMPK signaling governs metabolic remodeling in myocardial remodeling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Weizhou Jiang, Huan Liu, Rongxue Wan, Yanjiao Wu, Zhanjun Shi, Wenhua Huang
Summary: Mechanical loading is crucial for chondrocyte health, with mitochondria playing a critical role as mechanotransducers. Research has focused on the link between mechanical loading-induced mitochondrial dysfunction and the pathogenesis of osteoarthritis. There is a need for further investigation into the mechanisms behind mitochondrial functional alterations induced by mechanical stimulation.
AGEING RESEARCH REVIEWS
(2021)
Review
Cell Biology
Brendon J. Gurd, Eveline Soares Menezes, Benjamin B. Arhen, Hashim Islam
Summary: The purpose of this review is to explore the impacts of augmented training volume, intensity, and duration on the activation of key signaling proteins involved in mitochondrial biogenesis. The results of the studies are inconsistent, with some supporting the effects of intensity and duration on AMPK and CaMKII activation, while others do not. The literature on PGC-1 alpha expression is also inconsistent, and a meta-analysis suggests that the small effect size and limitations in sample size and statistical power may contribute to this inconsistency.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Francesco Agostini, Marco Bisaglia, Nicoletta Plotegher
Summary: Reactive oxygen species (ROS) generated from incomplete oxygen reduction can interact with and influence the function of various targets, including DNA, lipids, and proteins. AMP-activated protein kinase (AMPK), known as a major sensor of intracellular energy status, has been shown to play a crucial role in regulating cellular processes such as autophagy and lysosomal function. Through its modulation, AMPK can participate in the crosstalk between mitochondria and lysosomes by perceiving signals related to mitochondrial dynamics and transducing them to lysosomes, thereby impacting autophagic flux. Future studies should focus on the specific contribution of different AMPK subpopulations to the autophagic pathway, considering the tissue-specific regulation and localization of AMPK.
Article
Endocrinology & Metabolism
Mehmet M. Altintas, Salvatore DiBartolo, Lana Tadros, Beata Samelko, Haimanot Wasse
Summary: This study aimed to elucidate mitochondrial function and associated stress pathologies in kidney disease using peripheral blood mononuclear cells (PBMCs) of hemodialysis patients. The analysis revealed a significant reduction in mitochondrial respiration in ESKD patient PBMCs, correlated with changes in key bioenergetic parameters and protein expression levels. The findings suggest a link between mitochondrial dysfunction and ESKD, with potential therapeutic implications.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Immunology
Yuanyuan Zhou, Ming Li, Zhenglei Wang, Xinguang Lin, Yuanyuan Xu, Shiyuan Feng, Jinfeng Miao
Summary: Excessive production of ROS leads to oxidative stress, affecting disease progression. Mitochondria are a significant source of ROS, and their dysfunction is closely associated with ROS production. S. uberis infection disrupts mitochondrial dynamics, leading to fragmentation and functional decline. The AMPK activator AICAR improves mitochondrial dysfunction induced by S. uberis infection by inhibiting Drp1 phosphorylation and translocation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Fisheries
Xi Wang, Kang Xiao, Guang-Zhen Jiang, Yong-Jun Dai, Kenneth Abasubong, Mang-Mang Wang, Xiang-Fei Li, Ding-Dong Zhang, Wen-Bin Liu
Summary: The study found that unsaturated fatty acids have significant effects on the growth performance and muscle quality of Megalobrama amblycephala, promoting muscle fiber development and improving meat quality. This effect may be realized by activating AMPK and Ca2+-dependent signal pathways.
AQUACULTURE REPORTS
(2022)
Article
Multidisciplinary Sciences
Joshua C. Drake, Rebecca J. Wilson, Rhianna C. Laker, Yuntian Guan, Hannah R. Spaulding, Anna S. Nichenko, Wenqing Shen, Huayu Shang, Maya Dorn, Kian Huang, Mei Zhang, Aloka B. Bandara, Matthew H. Brisendine, Jennifer A. Kashatus, Poonam R. Sharma, Alexander Young, Jitendra Gautam, Ruofan Cao, Horst Wallrabe, Paul A. Chang, Michael Wong, Eric M. Desjardins, Simon A. Hawley, George J. Christ, David F. Kashatus, Clint L. Miller, Matthew J. Wolf, Ammasi Periasamy, Gregory R. Steinberg, D. Grahame Hardie, Zhen Yan
Summary: Mitochondria form a complex, interconnected reticulum maintained through coordination among biogenesis, dynamic fission, fusion and mitophagy in response to various cues. Specific isoforms of AMP-activated protein kinase are localized on the outer mitochondrial membrane and vary in activation across the reticulum in response to energetic stress. The discovery highlights the complexity of sensing cellular energetics in vivo and its implications for targeting mitochondrial energetics in disease treatment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Liting Hang, Ziyin Wang, Aaron S. C. Foo, Geraldine W. Y. Goh, Huey Ching Choong, John Thundyil, Shengli Xu, Kong-Peng Lam, Kah-Leong Lim
Summary: Emerging studies suggest that energy dysregulation is a key factor in Parkinson's disease, and AMP kinase (AMPK) plays a crucial role in maintaining neuronal energy homeostasis. Loss of AMPK function can promote dopaminergic neurodegeneration and increase susceptibility to toxin-induced damage, making the AMPK pathway a promising therapeutic target for PD.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Multidisciplinary Sciences
Eric M. Desjardins, Brennan K. Smith, Emily A. Day, Serge Ducommun, Matthew J. Sanders, Joshua P. Nederveen, Rebecca J. Ford, Stephen L. Pinkosky, Logan K. Townsend, Robert M. Gutgesell, Rachel Lu, Kei Sakamoto, Gregory R. Steinberg
Summary: This study demonstrates the important physiological role of AMPK ss 1 Ser108 phosphorylation in promoting fatty acid oxidation, mitochondrial biogenesis, and autophagy under conditions of high lipid availability.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Ara Yoo, Yeonhee Joo, Yeongmi Cheon, Sung Joong Lee, Soojin Lee
Summary: Neuronal growth regulator 1 (NEGR1) is a membrane protein associated with obesity, depression, and autism, and it regulates cellular fat content by interacting with CD36.
JOURNAL OF LIPID RESEARCH
(2022)
Article
Chemistry, Applied
Yi Wu, Minhua Zong, Zhenhui Zhang, Yongtai Wu, Lin Li, Xia Zhang, Hong Wu, Bing Li
Summary: This study identifies the selective transmembrane transport of different modification types of AGEs and their effects on cellular energy homeostasis. The results show that only certain types of free and peptide-bound AGEs can easily cross the cell membrane and exert their effects. Mechanistically, free AGEs interfere with mitochondrial function and energy production through the thymidine phosphorylase and AMPK-SIRT6 signaling pathways.
Article
Toxicology
Yewen Cong, Yujing Hong, Dandan Wang, Pei Cheng, Zhisheng Wang, Changming Xing, Wenxing Sun, Guangfei Xu
Summary: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is widely recognized as the most toxic and prevalent carcinogen in the world. Exposure to TCDD causes disorder in liver lipid metabolism and leads to steatosis. The molecular mechanism of TCDD-induced liver lipid accumulation is not fully understood.
TOXICOLOGICAL SCIENCES
(2023)
Review
Physiology
Minyu Zhang, Biyang Xiao, Xiaoqi Chen, Bingming Ou, Songtao Wang
Summary: Non-alcoholic fatty liver disease (NAFLD) is closely related to bile acid and gut microbiota disorders. Exercise plays an important role in maintaining the homeostasis of the enterohepatic circulation and the health of the host gut microbiota by regulating the composition and function of the bile acid pool in the enterohepatic axis. Exercise has been recommended as a first-line intervention for NAFLD, and regulating bile acids through exercise may be a promising treatment strategy.